DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and AgaP_AGAP004424

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_313707.5	Gene:	AgaP_AGAP004424 / 1274566	VectorBaseID:	AGAP004424	Length:	626	Species:	Anopheles gambiae

Alignment Length:	599	Identity:	127/599 - (21%)
Similarity:	200/599 - (33%)	Gaps:	203/599 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 VNQHFPVQISKESDERICGRCWKIVSDFHTLHEFVS--AAQSSLQETKVALMEDDPLTQETTSFP 100
            :|:|......:|.:...||.|    .:....|.:.|  |..:.|||...|  |||..|
Mosquito   149 LNRHLRTAHGQEVNPYYCGHC----RNAEATHRYDSYVALMNHLQEQHSA--EDDTTT------- 200

  Fly   101 EIIKLATQEEEGVTEPQELGGRNFFYPEIKIEEHELDTLPRIEILERSANTQENQDQLEGAARRL 165
                 |.:|..|......|.|:                  .:|:||........||:.......:
Mosquito   201 -----AAKELHGTLLNASLFGK------------------ELELLEDDKVVDVEQDRFLQNLHLV 242

  Fly   166 RKRLKAEDGSSVDKDKDEDGVEETAEPAPPKKRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDE 230
            |                       :.|..||            ...|.:|:.|     :...|::
Mosquito   243 R-----------------------SVPERPK------------TCQPLEPRID-----QRTVLED 267

  Fly   231 FVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDSDFE--LDNGKQ----EFAVLPKRTVVRPKKYK 289
            |:||.                       |::|..:.  :|||::    ::.:           |.
Mosquito   268 FLDET-----------------------FENDEIWNKYIDNGEEYLIDDYDI-----------YL 298

  Fly   290 KRTKPAEPKVRMSRELLEQRKK-----------QQEEYDVIIAKFFTSVLPCAIC--------NL 335
            |....:|.:..:...|..|.|:           ..||:||       |.|.|..|        :.
Mosquito   299 KGMDESEKQEEVCMYLCPQCKQGFQSQRNLTIHLAEEHDV-------SSLVCNDCGASFTRHASY 356

  Fly   336 LVH--------------NFTEMQRHHRL---------THQVDPGYMMCCG---RKFTQRKVLAEH 374
            .:|              |..||:....|         .|:.:.||:..|.   |.|.::..|.:|
Mosquito   357 RIHRREHLKENVRFRESNIPEMEEALSLVQSTSLDYSVHEEESGYVFTCNLCDRTFQRKHNLEKH 421

  Fly   375 VLVHWNP-DHF----------------KCSVCEKSFQNSRHLESHQQ-VH---MDPAVKLTFSCD 418
            ..:::.. :|.                :||.|:....:|:.||:||| :|   |:|:..:  .|.
Mosquito   422 RCLYYEQLEHSNTSAQQGAGVNGTELQQCSHCQFRTTSSQELETHQQRIHQSDMEPSEPV--YCM 484

  Fly   419 LCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQ 483
            ||.:.|.|.:.:.|| |.:|....  .|.|..|.|.|.....|..|:.|:|.......||:|.:.
Mosquito   485 LCDRRFSSISGLKYH-LKRHTGIK--AFACLYCEKTFTANSNLNAHIRSVHSARKDYRCDECNES 546

  Fly   484 MRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGEHRCHICAKVS 548
            ..||..|.|||...|    |.|... .|..||......:.|.:|:.:.|.|.  .:.||:|....
Mosquito   547 FTTKDHLNKHQRSRH----RQERAF-VCGECGKNYLQRSHLNEHVAASHRED--RYLCHVCNGSY 604

  Fly   549 PNARALRRHIYHNH 562
            .:..:|:||....|
Mosquito   605 VSKSSLKRHQQQKH 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	10/44 (23%)
		FYDLN_acid	<191..268	CDD:302856	12/78 (15%)
		C2H2 Zn finger	330..351	CDD:275368	7/51 (14%)
		C2H2 Zn finger	360..378	CDD:275368	5/20 (25%)
		LIM	361..>400	CDD:295319	10/58 (17%)
		C2H2 Zn finger	386..406	CDD:275368	9/20 (45%)
		zf-C2H2_8	389..465	CDD:292531	25/79 (32%)
		C2H2 Zn finger	417..438	CDD:275368	8/20 (40%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	9/20 (45%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368
		C2H2 Zn finger	598..619	CDD:275368
AgaP_AGAP004424	XP_313707.5	C2H2 Zn finger	20..41	CDD:275368
		zf-C2H2_8	23..109	CDD:292531
		C2H2 Zn finger	54..75	CDD:275368
		C2H2 Zn finger	83..103	CDD:275368
		C2H2 Zn finger	108..127	CDD:275368
		C2H2 Zn finger	136..157	CDD:275368	2/7 (29%)
		C2H2 Zn finger	315..335	CDD:275368	2/19 (11%)
		C2H2 Zn finger	343..363	CDD:275368	3/19 (16%)
		C2H2 Zn finger	405..422	CDD:275368	4/16 (25%)
		C2H2 Zn finger	450..471	CDD:275368	9/20 (45%)
		COG5048	<459..613	CDD:227381	50/165 (30%)
		C2H2 Zn finger	483..503	CDD:275368	8/20 (40%)
		C2H2 Zn finger	511..532	CDD:275368	7/20 (35%)
		C2H2 Zn finger	540..558	CDD:275368	8/17 (47%)
		C2H2 Zn finger	569..589	CDD:275368	5/19 (26%)
		C2H2 Zn finger	597..614	CDD:275368	5/16 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910