DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and AgaP_AGAP003566

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_562406.4	Gene:	AgaP_AGAP003566 / 1274221	VectorBaseID:	AGAP003566	Length:	768	Species:	Anopheles gambiae

Alignment Length:	795	Identity:	183/795 - (23%)
Similarity:	302/795 - (37%)	Gaps:	202/795 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSSPSCLLCMCEYPAMMGDYIDVHSARGDQLEVTTIVNQHFPVQISKESDERICGRCWKIVSDF 65
            |:...:|:||:...|.   .::.|::......::.:::.:|..|:.:|  |..:|..|||.::||
Mosquito     1 MEQFVNCVLCLTTEPQ---SFLKVYNEEKQDTDIASVITKHLWVKPAK--DSYVCDECWKCLNDF 60

  Fly    66 HTLHEFVSA------------AQSSLQETKVALMEDDP--------LTQETTSFPEI----IKLA 106
               |||.:.            |..:.::.:..|.|..|        |:|......||    ::..
Mosquito    61 ---HEFYTKLENIHYPPDPEDASCNAKDIRQYLFEFHPVEDVKIEELSQNAEDMEEIEYEYLEAC 122

  Fly   107 TQE-------EEGVTEPQELGGRNFFYPEIKIE----EHELDTLPRIE-------------ILER 147
            .:|       |.....|:........|   |||    |.|.|.|...|             ..:.
Mosquito   123 NEETIENENAERSSGRPKRASAAQANY---KIEAAESEWEKDYLATNEDEYDDDDDDDDEADADY 184

  Fly   148 SANTQENQDQLEGAARRLRKRLKAEDGSSV------DKDKDEDGV--EETAEP-APPKKRRGRPR 203
            :.:.:|..|.||          :..|.|.|      .|.|.|.|.  |..:|| :|||:.||||.
Mosquito   185 NGDEKEEVDYLE----------EDNDDSEVINYDSPSKAKQEPGTKKEPASEPTSPPKRGRGRPP 239

  Fly   204 KSDAAVAPPQKPKEDIQLDLKAEELD-EFVDEETDPDFSCLVPSD------NSSEDDGGSD---- 257
            |:...:....:||..::...:..::. ...|.|.:.||...:..:      |:|:|.|...
Mosquito   240 KAKPEIEIKPEPKSKLRRRGRKRKVSVSSSDSELESDFDDFIDGEDWKKYRNTSKDKGRRSLGFR 304

  Fly   258 ---------------------------------------------------------GFDSDSDF 265
                                                                     ||.|..:.
Mosquito   305 QLQEKIFSYVDEFICYYCPEKIVFERFHHANLHYKKVHNEPAFLRCPKCGKKCFTPGGFVSHMET 369

  Fly   266 ELDNGKQEFAVLPKRT--VVRPKKYKK-----------------RTKPAEPKVRMSRELLEQRK- 310
            ..|..:.:..:..|.|  .:..||:.:                 ..:..|.:.|...|.|..||
Mosquito   370 HEDPERNKCKICGKVTDQEITLKKHMRAHQENLEKDFPYPCSLCNRRFEEEEKREKHERLHGRKL 434

  Fly   311 --KQQEEYDVIIAKFFTSVLPCAIC------NLLVHNFTEMQRHHRLTHQVDPGYMMC--CGRKF 365
              |:::..|:.:.:|:..:. |.:|      :....||.:::.|....|...| ::.|  |.:|.
Mosquito   435 IIKKEKGRDLELLEFYKRIY-CEVCEEKKPESTSFDNFWDLKVHMGNEHNKTP-FLKCPICFKKN 497

  Fly   366 TQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKL----TFSCDLCSKTFLS 426
            ..|:.|..||.||.||::::|.||::..||   ||.|......|...|    .:||:.|.|.|..
Mosquito   498 VCRQQLMVHVDVHNNPENYRCEVCKEIHQN---LEKHMIKAHTPETSLPDEKNYSCEHCGKMFKY 559

  Fly   427 KTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILK 491
            :|.:..|....|..|.   .:|..|:|.| ..:.|..|..|.|..| ..:|:.|.|..:|:..|:
Mosquito   560 QTNLKSHIDRVHGVKD---VSCDICHKYF-NSKALSAHKRSAHTDE-MFMCEHCPKMFKTRSGLE 619

  Fly   492 KHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGEHRCHICAKVSPNARALRR 556
            .|:    ||......:..||.|||..::....:.:|||:||.:. ....|.:|.||......:.|
Mosquito   620 SHK----SDHDETLRKSVQCLICGKEMRRGASMAKHMKTIHSQE-DPVSCDLCGKVFRTTFHMMR 679

  Fly   557 HIYHNHEC-----ERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQ 616
            |  ..:.|     .|.:||.:|.|.|.....:.||.:|||...||.|..|..||...:|:||||:
Mosquito   680 H--RANTCSATIDSRPYKCEVCGKGFAMKLTMTEHMTTHTRTSLYQCAFCFKTFGYISNLYKHRK 742

  Fly   617 RLHRAQYEADKNQPK 631
            :.|..:::..:.:|:
Mosquito   743 KAHPLEWQEVQARPE 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	19/85 (22%)
		FYDLN_acid	<191..268	CDD:302856	23/145 (16%)
		C2H2 Zn finger	330..351	CDD:275368	5/26 (19%)
		C2H2 Zn finger	360..378	CDD:275368	7/19 (37%)
		LIM	361..>400	CDD:295319	15/38 (39%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	22/79 (28%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	6/20 (30%)
		C2H2 Zn finger	511..532	CDD:275368	7/20 (35%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	9/20 (45%)
AgaP_AGAP003566	XP_562406.4	zf-AD	7..71	CDD:214871	18/71 (25%)
		C2H2 Zn finger	319..342	CDD:275368	0/22 (0%)
		C2H2 Zn finger	350..370	CDD:275368	3/19 (16%)
		C2H2 Zn finger	378..398	CDD:275368	4/19 (21%)
		C2H2 Zn finger	490..510	CDD:275368	7/19 (37%)
		C2H2 Zn finger	518..536	CDD:275368	8/20 (40%)
		COG5048	<527..680	CDD:227381	46/165 (28%)
		C2H2 Zn finger	550..571	CDD:275368	6/20 (30%)
		C2H2 Zn finger	578..598	CDD:275368	7/20 (35%)
		C2H2 Zn finger	605..625	CDD:275368	7/23 (30%)
		C2H2 Zn finger	635..656	CDD:275368	7/20 (35%)
		C2H2 Zn finger	664..683	CDD:275368	6/20 (30%)
		C2H2 Zn finger	724..742	CDD:275368	8/17 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910