DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and ZNF684

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_689586.3	Gene:	ZNF684 / 127396	HGNCID:	28418	Length:	378	Species:	Homo sapiens

Alignment Length:	321	Identity:	83/321 - (25%)
Similarity:	125/321 - (38%)	Gaps:	66/321 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 MSRELLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVDPGYMMC--CGR 363
            ||..|...|||..:.::           .|...||      ::.:::| ::.|:..| .|  ||:
Human   121 MSTSLNPMRKKSYKSFE-----------KCLPPNL------DLLKYNR-SYTVENAY-ECSECGK 166

  Fly   364 KFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKT 428
            .|.::.....|...|.....|:|:.|.|::....||.:||::|..   :..|.|:.|.|.|:.|.
Human   167 AFKKKFHFIRHEKNHTRKKPFECNDCGKAYSRKAHLATHQKIHNG---ERPFVCNDCGKAFMHKA 228

  Fly   429 AIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKH 493
            .:..|   :.:...|..:.||:|.|.|........|:.| |..|.:..|.:|||..|....|.||
Human   229 QLVVH---QRLHTGEKPYECSQCGKTFTWNSSFNQHVKS-HTLEKSFECKECGKTFRYSSSLYKH 289

  Fly   494 QELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGEHRCHICAKVSPNARALRRHI 558
            ......:||                                    ::|.||.|...|...|..|
Human   290 SRFHTGEKP------------------------------------YQCIICGKAFGNTSVLVTH- 317

  Fly   559 YHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLH 619
            ...|..|:.:.|..|.|||.:...|..|..|||||..|.|..|...|...:|:..| |::|
Human   318 QRIHTGEKPYSCIECGKAFIKKSHLLRHQITHTGEKPYECNRCGKAFSQKSNLIVH-QKIH 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856
		C2H2 Zn finger	330..351	CDD:275368	4/20 (20%)
		C2H2 Zn finger	360..378	CDD:275368	5/19 (26%)
		LIM	361..>400	CDD:295319	10/38 (26%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		zf-C2H2_8	389..465	CDD:292531	20/75 (27%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	8/20 (40%)
		C2H2 Zn finger	511..532	CDD:275368	0/20 (0%)
		C2H2 Zn finger	541..562	CDD:275368	7/20 (35%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	6/20 (30%)
ZNF684	NP_689586.3	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	161..181	CDD:275368	5/19 (26%)
		zf-H2C2_2	173..198	CDD:290200	6/24 (25%)
		COG5048	<185..345	CDD:227381	51/203 (25%)
		zf-C2H2	187..209	CDD:278523	8/21 (38%)
		C2H2 Zn finger	189..209	CDD:275368	7/19 (37%)
		zf-H2C2_2	201..224	CDD:290200	9/25 (36%)
		C2H2 Zn finger	217..237	CDD:275368	6/22 (27%)
		zf-H2C2_2	230..253	CDD:290200	6/25 (24%)
		C2H2 Zn finger	245..265	CDD:275368	7/20 (35%)
		C2H2 Zn finger	273..293	CDD:275368	8/19 (42%)
		zf-H2C2_2	285..308	CDD:290200	9/58 (16%)
		C2H2 Zn finger	301..321	CDD:275368	7/20 (35%)
		zf-H2C2_2	314..336	CDD:290200	7/22 (32%)
		COG5048	325..>378	CDD:227381	20/54 (37%)
		C2H2 Zn finger	329..349	CDD:275368	7/19 (37%)
		zf-H2C2_2	341..366	CDD:290200	11/24 (46%)
		C2H2 Zn finger	357..377	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910