DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and AgaP_AGAP002705

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_312223.5	Gene:	AgaP_AGAP002705 / 1273263	VectorBaseID:	AGAP002705	Length:	660	Species:	Anopheles gambiae

Alignment Length:	610	Identity:	128/610 - (20%)
Similarity:	212/610 - (34%)	Gaps:	159/610 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 IKIEEHELDTLPRIE--ILERSANTQENQDQLEGAARRLRKRLKAEDGSSVDKDKDEDGV----E 187
            |::|:.....:|:.|  |::..|......:|.|...:.::   :.|...||.|..:...:    .
Mosquito    47 IQLEKQPEPVVPKEEPVIIDVDALGMSETEQDESEQKEIK---QLETKHSVAKQNETKQIAPILS 108

  Fly   188 ETAEPAPPK----KRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDFSCLVP--- 245
            |.|:|..||    .::..|::::.      |..|.||...|..|..:.|.::.:|....:.|
Mosquito   109 EVAKPIEPKLSVVAKQIEPKQNET------KQIEPIQSGSKLNETRQDVPKQIEPKQIAMEPIVM 167

  Fly   246 --------------------SDNSSEDDG--------------GSDGFDSD-------------- 262
                                ..::.|.||              .:|.:|:|
Mosquito   168 GHDVIEQDAMEQDAMEQDFIEQDAMEQDGTEQYDTEQYDTEQYDTDQYDTDQYDTEQYDTEQYDT 232

  Fly   263 --SDFELD----NGKQEFAVLPKRTVVRPKKYKKRTKPAEPKVRMSR--ELLEQRKKQQEEY--- 316
              .|.|.|    ||.::..::.:...:.|.............||.|.  |||.: .:..|||
Mosquito   233 EQDDTEQDDTEQNGTEQNGMVLENGFISPSTSTAPMSSMSSDVRKSELSELLNE-AEYLEEYLMA 296

  Fly   317 -----------------DVIIAK-----------FFTSVLP-----------CAICNLLVHNFTE 342
                             ...:|:           ..:.|:|           |.:|.|::.....
Mosquito   297 DPEEPTEEQFPKPAPIGGATVAEAEDNNNGIEDDLQSIVVPGEDGIREIQNQCHVCGLILSKLAH 361

  Fly   343 MQRHHRLTHQVDPGYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHM 407
            ::||.:                            .|.....|||:||.|||..:.:|.:||::|
Mosquito   362 LKRHMK----------------------------AHAGTKPFKCNVCSKSFSRADNLRAHQRMH- 397

  Fly   408 DPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKF-TCSECNKKFLTERKLKNHMSSMHDP 471
              ..:..:.|.||.:.|....|...|..:.|....|..: .|:.|:..|.|:.||..|| .:|..
Mosquito   398 --TAEKNYKCPLCDERFKRVDAAKAHMGSAHRDFVEANYHVCTVCDNFFKTDEKLIAHM-ELHRG 459

  Fly   472 ESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESA 536
            .:.::||.||||....:..:.|  |........:|....|..|.........|..||:.:.....
Mosquito   460 VNRLVCDVCGKQFVGMMAYEAH--LQRHAAESEQPTTYSCAHCDKKFSSKAYLLMHMRYMMANKC 522

  Fly   537 GEHRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNC 601
            .|  |..|.|.......|:.|..: |...:.|.|..|.|:|.|...|..|..|||||..:.|..|
Mosquito   523 LE--CKYCGKKFARQSELKSHEDY-HTGIKPFTCKTCGKSFHRQCTLVVHMRTHTGEKPFQCSYC 584

  Fly   602 PMTFFCSANMYKHRQRLHRAQYEAD 626
            |.:|:...:|..|.:|....:|:.:
Mosquito   585 PKSFYQKNDMLTHERRHTGERYQCE 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	21/133 (16%)
		C2H2 Zn finger	330..351	CDD:275368	5/20 (25%)
		C2H2 Zn finger	360..378	CDD:275368	0/17 (0%)
		LIM	361..>400	CDD:295319	9/38 (24%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		zf-C2H2_8	389..465	CDD:292531	22/76 (29%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	8/20 (40%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	7/20 (35%)
AgaP_AGAP002705	XP_312223.5	zf-AD	<1..46	CDD:214871
		penta_MxKDx	<158..196	CDD:131998	2/37 (5%)
		C2H2 Zn finger	349..369	CDD:275368	5/47 (11%)
		zf-H2C2_2	361..386	CDD:290200	11/52 (21%)
		C2H2 Zn finger	377..397	CDD:275368	9/19 (47%)
		zf-H2C2_2	389..414	CDD:290200	8/27 (30%)
		C2H2 Zn finger	405..422	CDD:275368	5/16 (31%)
		C2H2 Zn finger	437..457	CDD:275370	8/20 (40%)
		COG5048	<481..635	CDD:227381	36/134 (27%)
		C2H2 Zn finger	497..517	CDD:275370	5/19 (26%)
		C2H2 Zn finger	525..545	CDD:275368	5/20 (25%)
		zf-H2C2_2	537..562	CDD:290200	8/25 (32%)
		C2H2 Zn finger	553..573	CDD:275368	7/19 (37%)
		zf-H2C2_2	566..588	CDD:290200	10/21 (48%)
		C2H2 Zn finger	581..601	CDD:275368	6/19 (32%)
		C2H2 Zn finger	608..627	CDD:275368	0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910