DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and AgaP_AGAP003446

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_311737.5	Gene:	AgaP_AGAP003446 / 1272820	VectorBaseID:	AGAP003446	Length:	1141	Species:	Anopheles gambiae

Alignment Length:	809	Identity:	160/809 - (19%)
Similarity:	266/809 - (32%)	Gaps:	225/809 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CLLCMCEYPAMMGDYIDVHSAR--GDQLEVTTIVNQHFPVQISKESDERICGRCWKIVSDFHTLH 69
            |.:|.|.:.::  .|:.:|..|  |.....:.......|.........|.|.|.    |....:|
Mosquito   334 CDICNCRFYSV--SYLALHKKRYHGPNAARSMTNGTSIPCHYCSRWFLRECDRS----SHIKQMH 392

  Fly    70 EFVSAAQSSLQETKVALMEDDPLTQETTSFPEIIKLATQEEEGVTEPQELGGRNF---------- 124
            ..:.|::.|.......|.:..|...|..:.||::.....|...|.:.:|..|...
Mosquito   393 ADMHASKESAAGFNQLLEDCPPADSEGLTDPEMLPPNVHEPMMVIKEEEPDGHEAAASNSVANNP 457

  Fly   125 ----FY---------PEIKIEEHELDTLP-----RIEILERSA-----NTQENQDQLEGAAR--- 163
                ||         .|....||..|..|     .::.|:.::     ..||.|||.....:
Mosquito   458 DTLQFYCYSCAMPFDTEDMFSEHLDDQHPFGGEQLMDQLQSASPFGEQQQQEQQDQDANVFKCPY 522

  Fly   164 ---------RLRKRLK---AEDGSSVD---------------KDKDEDGVEET----AEPAPPKK 197
                     .|.:.|.   |:.|...:               :.:....:.||    ....|...
Mosquito   523 CPKTFTRKWSLTQHLPTHIAKKGYQCEYCPAIFTRNEYLRTHRKRKHPNLPETGAHKCSYCPRMF 587

  Fly   198 RRGRPRKSDAAVAPPQK----PKEDIQLDLKAEELDEF----VDEETDPDFSCLVPSDNSSEDDG 254
            ...|.:|....:|..:|    |:.|   |.::.|:...    |:::.|...:.|.|...|.
Mosquito   588 NMVRYKKVHERIAHIKKGDILPEGD---DTESSEVAAINSLQVEKQLDESSNSLAPELPSR---- 645

  Fly   255 GSDGFD-SDSDFELDNGKQEFAVLPKRTVVRPKKYKKRTKPAEPKVRMSRELLEQRKKQQEEYDV 318
            .||.|| :.:|.......|.:|.|           :..::.|....|:..:.|||.:.|.|.|
Mosquito   646 ASDSFDQASNDAPSVASVQNYADL-----------EASSRLAVVLERLPAQELEQYRWQLEHY-- 697

  Fly   319 IIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVDPGYMMCCGRKFTQRKVL------AEHVLV 377
                   :.||..|         |::|     ..:||.|....|..|....|.      .||.:
Mosquito   698 -------ASLPPVI---------EIKR-----ELLDPQYGDIEGEGFNDNAVYDGNNYDDEHEV- 740

  Fly   378 HWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFS---CDLCSKTFLSKTAIDYHKLNKHV 439
              ..:....:..|.|||..:..:|.:|:......|...:   |..|||.|.::||:..|.|   .
Mosquito   741 --EEEDAASNDAEDSFQPDQSNDSGKQLLKRKRTKFGITLHPCPHCSKLFKTRTALRLHAL---Y 800

  Fly   440 PKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTII-----CDKCGKQMRTKIILKK-----HQ 494
            ...:....|.||..:|:...:|..|.:..|...|..:     ||.|     .:|.|:|     ||
Mosquito   801 HSGDLPHRCDECGVQFMRYNQLVYHTNRYHGANSATMAARYSCDYC-----PRIFLRKQDRTTHQ 860

  Fly   495 ELMHS-------DKPRPEPEL----------QQCQICGAWLKGMTGLKQHMKSIHVESAGEHRCH 542
            .::|:       ||   .|.|          ..|::|.|..:......:|:..||..|.||..|.
Mosquito   861 LMVHARDQANAIDK---SPALTIAKKTKRKDYVCRVCDAEFEKYRRCVRHITLIHAGSDGEPECR 922

  Fly   543 --------ICAKVSPNARALRRHI--------YHNHECERK----------FKCTMCEKAFKRPQ 581
                    ||:.:.........|:        :|..:|.|:          .:|:.|.|||:...
Mosquito   923 PIKLCHCSICSGIYKKRDDWHEHLNDHPSVRPHHCEQCIRRRRKASSRKQVHRCSYCPKAFEHKP 987

  Fly   582 ELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLH-RAQYEADKNQPKP-----PNILKISR 640
            .|..|...|..::.:.|..|.:.:....::..|:.|.| ..|.::...:|.|     |.:....|
Mosquito   988 NLASHLRIHKQQLRFPCSECGVMYDRYRDLLTHQSRYHPENQDDSVAREPLPKCNFCPRVFTRQR 1052

  Fly   641 ------------------NASTQNKPKQE 651
                              :|...|:|:::
Mosquito  1053 DVKYHQEQVHADQVIPAGDAEATNEPEED 1081

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	15/75 (20%)
		FYDLN_acid	<191..268	CDD:302856	19/85 (22%)
		C2H2 Zn finger	330..351	CDD:275368	3/20 (15%)
		C2H2 Zn finger	360..378	CDD:275368	5/23 (22%)
		LIM	361..>400	CDD:295319	9/44 (20%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		zf-C2H2_8	389..465	CDD:292531	21/78 (27%)
		C2H2 Zn finger	417..438	CDD:275368	9/20 (45%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	8/25 (32%)
		C2H2 Zn finger	511..532	CDD:275368	4/20 (20%)
		C2H2 Zn finger	541..562	CDD:275368	5/36 (14%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	4/20 (20%)
AgaP_AGAP003446	XP_311737.5	zf-AD	26..100	CDD:214871
		C2H2 Zn finger	240..260	CDD:275368
		C2H2 Zn finger	269..290	CDD:275368
		COG5048	293..666	CDD:227381	63/344 (18%)
		C2H2 Zn finger	306..326	CDD:275368
		C2H2 Zn finger	334..352	CDD:275368	5/19 (26%)
		C2H2 Zn finger	371..389	CDD:275368	4/21 (19%)
		C2H2 Zn finger	520..540	CDD:275368	2/19 (11%)
		C2H2 Zn finger	548..569	CDD:275368	0/20 (0%)
		C2H2 Zn finger	580..599	CDD:275368	3/18 (17%)
		C2H2 Zn finger	781..801	CDD:275368	9/22 (41%)
		C2H2 Zn finger	809..830	CDD:275368	6/20 (30%)
		C2H2 Zn finger	843..860	CDD:275368	6/21 (29%)
		C2H2 Zn finger	929..949	CDD:275368	3/19 (16%)
		C2H2 Zn finger	976..996	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1004..1025	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1041..1058	CDD:275368	2/16 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100