DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and AgaP_AGAP000141

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_311004.5	Gene:	AgaP_AGAP000141 / 1272126	VectorBaseID:	AGAP000141	Length:	2237	Species:	Anopheles gambiae

Alignment Length:	653	Identity:	141/653 - (21%)
Similarity:	229/653 - (35%)	Gaps:	213/653 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 NTQENQDQLEGAARR-----LRKRLKAEDGSSVDKDK------------------------DEDG 185
            |.|:.|.|..|:|..     :.:..|.|....||.|.                        ||.|
Mosquito  1561 NLQQQQHQQHGSADAPLDGGMMQASKIEPPMDVDSDSGEVMPKLPFADMMVARMHEPPGAYDEVG 1625

  Fly   186 -----------------------VEET------------------AEPAPPKKRRGRPRKSDAAV 209
                                   .|||                  .:|.....|..||:.|.:.|
Mosquito  1626 SSHHHHHQQQQQQQTLHQPCEAKYEETIGTTSYFGVATCSAVPVMQQPTDDPVRPNRPKPSGSGV 1690

  Fly   210 APPQK---------PKEDIQLDLKAEELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDSDF 265
            |...:         ..:..:|..:.|.:|:.|          .:.|.:..|..|..|      :.
Mosquito  1691 ARTYRCTLCAKVFSSIKQRRLHQQCEHVDDLV----------ALSSSHQQEMRGEED------NK 1739

  Fly   266 ELDNGKQEFAVLPKRTVVRPKK------------------YKKRTKP---------------AEP 297
            .|.:|:|: ..||::...:.::                  |||...|               :|.
Mosquito  1740 PLMDGRQQ-QQLPQQQHQQQQQQQQQQQQQQQQAQQQQQIYKKAPIPVVMNYHWMKQEIERKSEA 1803

  Fly   298 KVRMSRELL-------------------EQRKKQQEEYDVII---------------------AK 322
            .:|.||.|:                   |....||::..:::                     |.
Mosquito  1804 ALRSSRLLMAGSSAGSSTTVVLPGTSSGEAAPGQQQQQQLVLEQHVQVQVQLQTDGGTVAALSAS 1868

  Fly   323 FFTSVLPCAICNLLVHNFT--------EMQR-----HHRLTHQVDPGYMMCCGRKFTQRKVLAEH 374
            ..:::||.|.|::...|.:        |..|     .|.|.|.|:   ...|||.|.|.:..:.|
Mosquito  1869 AESALLPAAHCSVAARNRSYVCSTCSREFDRFNLFNEHLLEHPVE---CSACGRHFKQWRNFSLH 1930

  Fly   375 VLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTF-----LSKTAIDYHK 434
            :..|......:|.:|.|.|...:.|..|.:||...|   ...|.||::||     |::....||
Mosquito  1931 IKRHLGIKEHQCRMCGKRFVIKQKLIEHMRVHTGHA---PIKCKLCNRTFKRFSNLAQHRKRYH- 1991

  Fly   435 LNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHD--PESTIICDKCGKQMRTKIILKKHQELM 497
            ||:.|.|.|  :.|..|.:.|.|..|::.|..: |:  |:|   |..|.::...:..|.:|..|.
Mosquito  1992 LNRTVVKEE--YVCQLCGEVFHTMAKMEWHKET-HEKKPKS---CPYCREKFIHRNSLTRHIRLS 2050

  Fly   498 HSDK-PRPEPELQQCQIC-GAWLKGMTGLKQHMKSIHVESAGEHRCHICAKVSPNARALRRHIY- 559
            |:|| .:.|.:.:.|.|| ..:.|  |.:::|::: |.:....:.|.||.|.......|::|.:
Mosquito  2051 HTDKYAKLENKTEPCSICQQPYTK--TSMRRHLET-HTKERMAYACGICNKRFTTNWNLKQHKWT 2112

  Fly   560 HNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYE 624
            |.:...:.|:||.|..||.|..:...|.:.|.....|||.:|...|....|..:|.:     ::|
Mosquito  2113 HTNPTMKPFQCTYCPSAFVRESDFVTHVNAHRSIRPYTCNHCGSQFIRKYNWIRHTR-----EHE 2172

  Fly   625 ADK 627
            .||
Mosquito  2173 IDK 2175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	15/85 (18%)
		C2H2 Zn finger	330..351	CDD:275368	7/33 (21%)
		C2H2 Zn finger	360..378	CDD:275368	6/17 (35%)
		LIM	361..>400	CDD:295319	11/38 (29%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		zf-C2H2_8	389..465	CDD:292531	26/80 (33%)
		C2H2 Zn finger	417..438	CDD:275368	10/25 (40%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	5/20 (25%)
		C2H2 Zn finger	511..532	CDD:275368	6/21 (29%)
		C2H2 Zn finger	541..562	CDD:275368	7/21 (33%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	5/20 (25%)
AgaP_AGAP000141	XP_311004.5	C2H2 Zn finger	1890..1910	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1914..1934	CDD:275368	6/19 (32%)
		zf-H2C2_2	1926..1950	CDD:290200	5/23 (22%)
		C2H2 Zn finger	1942..1962	CDD:275368	6/19 (32%)
		zf-H2C2_2	1955..1979	CDD:290200	10/26 (38%)
		COG5048	<1958..2223	CDD:227381	68/236 (29%)
		C2H2 Zn finger	1970..1988	CDD:275368	6/17 (35%)
		C2H2 Zn finger	2003..2023	CDD:275368	6/20 (30%)
		C2H2 Zn finger	2030..2048	CDD:275368	4/17 (24%)
		C2H2 Zn finger	2065..2084	CDD:275368	6/21 (29%)
		zf-H2C2_2	2076..2102	CDD:290200	6/26 (23%)
		C2H2 Zn finger	2093..2113	CDD:275368	6/19 (32%)
		zf-H2C2_2	2105..2132	CDD:290200	9/26 (35%)
		C2H2 Zn finger	2123..2143	CDD:275368	7/19 (37%)
		C2H2 Zn finger	2151..2171	CDD:275368	5/24 (21%)
		zf-C2H2	2177..2199	CDD:278523
		C2H2 Zn finger	2179..2199	CDD:275368
		zf-H2C2_2	2191..2216	CDD:290200
		C2H2 Zn finger	2207..2227	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910