DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and AgaP_AGAP009339

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_310010.4	Gene:	AgaP_AGAP009339 / 1271250	VectorBaseID:	AGAP009339	Length:	991	Species:	Anopheles gambiae

Alignment Length:	822	Identity:	177/822 - (21%)
Similarity:	273/822 - (33%)	Gaps:	247/822 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 CMCEYPAMMGDYIDVHSARGDQLEVTTIVNQH---FPV---------QISKESDE------RICG 56
            |.|.:.|.....:..||.....:|    :|.|   .|:         |:.:..||      .:|.
Mosquito   218 CGCSFVARSRKELLQHSETVHSVE----MNDHGDYCPICFYKFSTDQQLERHIDEFKLNKMYVCL 278

  Fly    57 RCWKIVSDFHTLHEFVSAAQSSLQETKV---ALMEDDPLTQETTSFPEIIKLATQEEEGVTEPQE 118
            ||.:..:....|...:......::|..|   ....||.||.|.....:     ..||||:.|..:
Mosquito   279 RCNRFYNVKRKLFNHLLECGGMVEEVDVQASGTNNDDALTIEALKEED-----GDEEEGLEEDSQ 338

  Fly   119 LGGRNFFYPEIKIEE----------HELDTL-----PRI-----EILERSANTQENQDQLEGAAR 163
                   |.|..::|          |..|.|     ||:     .:.|...:.:|...||.
Mosquito   339 -------YEECYLQEGTDTDEQQELHAEDRLQNATDPRVMHRYKALFEEVLSNEELYCQLS---- 392

  Fly   164 RLRKRLKAEDGSSVDKDKDEDGVEETAEPAPPKKRRGRP---------------RKSDAAVAPPQ 213
              .|.|..:|....     |..|.||.:..   :.||..               ..|:.| .||:
Mosquito   393 --EKELNVQDVQIA-----EQHVFETFKYI---RLRGLRCCGCSYTCMSKALLIEHSNLA-HPPE 446

  Fly   214 KPKEDIQLDLKAEEL--DEFVDE----------ETDPDFSCLVPSDNS--SEDDGGSDGFDSDSD 264
            .|.|.:  |..:.||  .||.:.          .|...|.|.| .|.|  :::...:....::..
Mosquito   447 NPPEHV--DEHSCELCRAEFQNTLNLVKHICFFTTRQLFLCTV-CDVSFLNKESLRNHQRHNERH 508

  Fly   265 FELDNGKQEFAVLP-------------------KRTVVRPKKYKKRTKPAEPKVRMSRELLEQRK 310
            .||:|.|.|.|.:.                   ::.||....|:.:.....|   |..|...:|:
Mosquito   509 RELENYKFEQAGIELDTAEGFVELDQPAVADELRKLVVEKISYRPKAVTCIP---MPDERFIRRR 570

  Fly   311 KQQEEYDVII---------AKFFTSV------------LP-----------CAICNLLVHNFTEM 343
            |:...|.|::         .:||.:.            ||           |.||    :...|:
Mosquito   571 KEYNNYSVLVVAGEYCCGCGRFFDTTSELQQHAEQEHYLPLNFCARTYGHQCEIC----YAVFEL 631

  Fly   344 QR----HHRLTHQVDPGYMMC--CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESH 402
            :|    |..::........:|  ||..|:::..||.|  :|..|:|....:.:.:....|..|.|
Mosquito   632 ERGFAVHRSMSRSKQKTLYLCKLCGLLFSKKFCLARH--MHSAPNHLSRLIVDAAANAYRTGEEH 694

  Fly   403 -------------QQVHMDPAVK--------------------LTFSC--DLCSKTFLSKTAIDY 432
                         :....||.||                    :.:.|  ..|.:||.|:.|:..
Mosquito   695 DAPEEADAEPGPPEAAVSDPRVKEALQLHRSVEAKGLRKVGHLVWYHCCFPKCPETFTSEAALLE 759

  Fly   433 HKLNKHV--------PKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKII 489
            |...:|.        .:.:....|..|.|.|.|..||..|......|.. ..|.:|.......:.
Mosquito   760 HAQAEHYGQRRENQNERQQDTNVCPTCCKPFQTLAKLYWHRVKRFVPRE-YKCKQCASTFDRWVQ 823

  Fly   490 LKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGEHRCHICAKVSPNARAL 554
            ||.|.|..||..|   |.. :|..||........|..|.|: |.:.. :|:|.:|.....:...|
Mosquito   824 LKIHVEQEHSATP---PSF-ECAECGKSFVLRARLVAHQKT-HTDRK-DHKCDVCGCAFVSKGLL 882

  Fly   555 RRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTF-------------- 605
            :||....|..|..|:|.:|.|.|...::||.|...||||..|.|..|..||
Mosquito   883 KRHRRALHATELLFECKLCSKKFAVVEKLKIHQRVHTGERPYECTFCSRTFIHFSDRKRHEMAAH 947

  Fly   606 ---------FCSANMYKHRQ-RLHRAQYEADKNQPKPPNILK 637
                     .|.|:..::|: .||..::::|   .|..|::|
Mosquito   948 TMERPYKCTLCPASYIRNRELNLHMQKHQSD---GKGKNLVK 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	16/88 (18%)
		FYDLN_acid	<191..268	CDD:302856	20/105 (19%)
		C2H2 Zn finger	330..351	CDD:275368	6/24 (25%)
		C2H2 Zn finger	360..378	CDD:275368	7/19 (37%)
		LIM	361..>400	CDD:295319	10/38 (26%)
		C2H2 Zn finger	386..406	CDD:275368	3/32 (9%)
		zf-C2H2_8	389..465	CDD:292531	22/118 (19%)
		C2H2 Zn finger	417..438	CDD:275368	7/22 (32%)
		C2H2 Zn finger	448..465	CDD:275368	7/16 (44%)
		C2H2 Zn finger	477..498	CDD:275368	6/20 (30%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	7/44 (16%)
AgaP_AGAP009339	XP_310010.4	zf-AD	30..102	CDD:285071
		C2H2 Zn finger	457..477	CDD:275368	4/19 (21%)
		C2H2 Zn finger	485..503	CDD:275368	4/18 (22%)
		C2H2 Zn finger	811..832	CDD:275368	6/20 (30%)
		C2H2 Zn finger	841..861	CDD:275368	6/20 (30%)
		C2H2 Zn finger	869..885	CDD:275368	3/15 (20%)
		C2H2 Zn finger	898..918	CDD:275368	7/19 (37%)
		zf-H2C2_2	911..933	CDD:290200	10/21 (48%)
		C2H2 Zn finger	926..947	CDD:275368	4/20 (20%)
		C2H2 Zn finger	955..975	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910