DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and AgaP_AGAP004060

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_309612.4	Gene:	AgaP_AGAP004060 / 1270875	VectorBaseID:	AGAP004060	Length:	606	Species:	Anopheles gambiae

Alignment Length:	663	Identity:	142/663 - (21%)
Similarity:	222/663 - (33%)	Gaps:	240/663 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PSCLLCMCEYPAMMGDYIDVHSARGDQLEVTTIVNQHFPVQISKESD--ERICGRCWKIVSDFHT 67
            |.|..|.||...|| ...|||....:.|.:..|          .|:.  ..|||.|.:.:.:|..
Mosquito    47 PLCRFCACENSQMM-HISDVHQQIINDLRIPGI----------HETSVCTNICGSCNRFLEEFCK 100

  Fly    68 LHEFVSAAQSSLQETKVALMEDDPLTQETTSFPEIIKLATQEEEGVTEPQELGGRNFFYPEIKIE 132
            ........|.                          :|||.          |.||:.....:|.|
Mosquito   101 FRSVCEEGQK--------------------------RLATL----------LSGRHVVSNYLKPE 129

  Fly   133 EHELDTLP------------------RIEILERSANTQENQDQLEGAARRLRKRLKAEDGSSVDK 179
            ..:.|.||                  .:||::.||....::     |.|         |..::|.
Mosquito   130 FTKRDLLPAQLNEPFDHNIRSELMLNSVEIVQTSAGYDASE-----AVR---------DAVNLDT 180

  Fly   180 D-KDEDGVEETAEPAPPKKRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDFSCL 243
            . |....||:|:           |.....||.  ::|  ||. |....|.:..:::||.
Mosquito   181 TCKLSPSVEDTS-----------PITLHIAVI--EQP--DIS-DQTNGEPEHSINQETG------ 223

  Fly   244 VPSDNSS------------------EDDGGSDGFDSDSDFELDNGKQEF-AVLPKRTVVRPKKYK 289
            |.|::||                  |:...|:.|:   :.|..|..|.| ||:.::
Mosquito   224 VESNHSSECGSELQETHESNHVHICEETNLSEYFE---NVENINNAQRFDAVIEEK--------- 276

  Fly   290 KRTKPAEPKVRMSRELLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVD 354
                        |.:.:..||:.|:                          ||.:|     ..||
Mosquito   277 ------------SNDTIVNRKRSQK--------------------------TEARR-----RVVD 298

  Fly   355 PGYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQ----VHMDPAVKL-T 414
                   ||             :.|     .|..||:.|.:...|:.|::    |....:.:. |
Mosquito   299 -------GR-------------LEW-----VCLDCEQVFPSCLQLKKHRRNCELVGSKTSKRFAT 338

  Fly   415 FSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKN--HMSSMHDPE-STII 476
            ..||:|.:|..:::|:..|| .||                   |.|:|.  .:..:..|. ..|.
Mosquito   339 LGCDICGETMSTESALTMHK-RKH-------------------ETKVKRPPALKPLPSPNLEPIF 383

  Fly   477 CDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGEHRC 541
            ||.||...::|..|:.|: :.||:..:.|     |.:||...|....|:.|::.   .|..::.|
Mosquito   384 CDVCGHASKSKRALRLHR-ITHSNDKQVE-----CHVCGKRFKRRRTLRIHLEG---HSGQKYEC 439

  Fly   542 HICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFF 606
            .:|.|.......||.|...:...:...:||:|::.|..|.:|::|..|||||..|.|..|...|.
Mosquito   440 EVCGKQFLTTVTLRNHAKTHRNSDAMHECTVCQRPFAHPNQLQKHMMTHTGEYPYVCEICNAMFR 504

  Fly   607 CSANMYKHRQRLH 619
            ......:|.||.|
Mosquito   505 TLGRYNRHMQRGH 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	18/75 (24%)
		FYDLN_acid	<191..268	CDD:302856	18/94 (19%)
		C2H2 Zn finger	330..351	CDD:275368	3/20 (15%)
		C2H2 Zn finger	360..378	CDD:275368	2/17 (12%)
		LIM	361..>400	CDD:295319	7/38 (18%)
		C2H2 Zn finger	386..406	CDD:275368	6/23 (26%)
		zf-C2H2_8	389..465	CDD:292531	19/82 (23%)
		C2H2 Zn finger	417..438	CDD:275368	7/20 (35%)
		C2H2 Zn finger	448..465	CDD:275368	3/18 (17%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	6/20 (30%)
AgaP_AGAP004060	XP_309612.4	zf-AD	49..112	CDD:214871	18/99 (18%)
		C2H2 Zn finger	341..361	CDD:275368	7/20 (35%)
		C2H2 Zn finger	384..404	CDD:275368	7/20 (35%)
		C2H2 Zn finger	412..432	CDD:275368	6/22 (27%)
		C2H2 Zn finger	439..459	CDD:275368	6/19 (32%)
		C2H2 Zn finger	468..488	CDD:275368	7/19 (37%)
		zf-H2C2_2	481..505	CDD:290200	11/23 (48%)
		C2H2 Zn finger	496..517	CDD:275370	6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910