DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and AgaP_AGAP002241

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_307943.4	Gene:	AgaP_AGAP002241 / 1269320	VectorBaseID:	AGAP002241	Length:	473	Species:	Anopheles gambiae

Alignment Length:	530	Identity:	109/530 - (20%)
Similarity:	180/530 - (33%)	Gaps:	138/530 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VTTIVNQHFPVQISKESDE----RICGRCWKIVSDFHTLHEFVSAAQSS----LQETKVALMEDD 90
            |..::.:.|..::|..:.|    .:|..|:..::|:...:......|..    ||.:.:.|.|:
Mosquito    36 VVQLLERFFERELSDRAIELEQSGVCKECYTKLNDYDAAYTKALIIQQELTDLLQNSNLRLFEE- 99

  Fly    91 PLTQETTSFPEIIKLATQEEEGVTEPQELGGRNFFYPEIKIEEH----------------ELDTL 139
                        :.:.:.::|.|...::.|       |||.|:.                .:|.|
Mosquito   100 ------------LHVQSDDDEKVKVDEQHG-------EIKWEQSGEVEQSGDANPTARMLSVDAL 145

  Fly   140 PRIEILERSANTQENQDQLEGAARRLRKRLKAEDGSSVDKDKDEDGVEETAEPAPPKKRRGRPRK 204
            |.|.|....|...|..:.|:.|      .|...|             |.:.|..||.|...   .
Mosquito   146 PTIRICMECAVCGETFNNLQDA------DLHTHD-------------EVSEEEQPPIKESS---N 188

  Fly   205 SDAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDSDFELDN 269
            |...:.......|.|..|...||.||              |.|:...:||
Mosquito   189 SSPMLVIETIGTEHIHADAAPEESDE--------------PGDSMYTEDG--------------- 224

  Fly   270 GKQEFAVLPKRTVVRPKKYKKRTKPAEPKVRMSRELLEQRKKQQEEYDVIIAKFFTSVLPCAICN 334
                        .|:| .||...|..|.....:|.  ||.::                :.|..|.
Mosquito   225 ------------CVQP-YYKTEMKDEEEAGDETRP--EQNRR----------------MACFYCE 258

  Fly   335 LLVHNFTEMQRHHRLTHQVDPGYMMC--CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSR 397
            ....:...::.|.:.:|.:|....:|  ||.....|..||.|:..|.......|:||.|.|....
Mosquito   259 ATFDDKVSLKEHFKTSHPIDLEKNICKVCGLTMKTRAALASHLGKHVRESQLTCNVCSKKFTQKT 323

  Fly   398 HLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKL-NKHVPKSEFKFTCSECNKKFLTERKL 461
            .|:.|..:|..   :..:.||.|.|.::..::...|:| :|.|...:    |:.|...|.:...|
Mosquito   324 SLQRHMAIHTG---EKAYQCDQCGKQYIHYSSFYMHQLAHKDVRAKK----CTICGNSFTSNSHL 381

  Fly   462 KNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQ 526
            |.||.: |..|....|..||::...:..:.:|.. .||.|.:...::.:|..|.......|.||:
Mosquito   382 KRHMRT-HSGEKPFDCPVCGQKFSQRYNMVQHLN-AHSGKTKRSVKMLKCPHCDQCSDRYTQLKK 444

  Fly   527 HMKSIHVESA 536
            |::..|.:.|
Mosquito   445 HLEKYHPDKA 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	9/54 (17%)
		FYDLN_acid	<191..268	CDD:302856	16/76 (21%)
		C2H2 Zn finger	330..351	CDD:275368	3/20 (15%)
		C2H2 Zn finger	360..378	CDD:275368	7/19 (37%)
		LIM	361..>400	CDD:295319	12/38 (32%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		zf-C2H2_8	389..465	CDD:292531	19/76 (25%)
		C2H2 Zn finger	417..438	CDD:275368	6/21 (29%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	4/20 (20%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368
		C2H2 Zn finger	570..590	CDD:275368
		C2H2 Zn finger	598..619	CDD:275368
AgaP_AGAP002241	XP_307943.4	C2H2 Zn finger	254..304	CDD:275368	12/49 (24%)
		C2H2 Zn finger	284..303	CDD:275370	7/18 (39%)
		C2H2 Zn finger	312..332	CDD:275368	7/19 (37%)
		zf-H2C2_2	324..347	CDD:290200	7/25 (28%)
		C2H2 Zn finger	340..388	CDD:275368	15/52 (29%)
		COG5048	367..>430	CDD:227381	16/68 (24%)
		zf-C2H2	367..388	CDD:278523	7/25 (28%)
		zf-H2C2_2	380..405	CDD:290200	9/25 (36%)
		C2H2 Zn finger	396..416	CDD:275368	4/20 (20%)
		C2H2 Zn finger	429..446	CDD:275368	5/16 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910