DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and ZNF689

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_612456.1	Gene:	ZNF689 / 115509	HGNCID:	25173	Length:	500	Species:	Homo sapiens

Alignment Length:	419	Identity:	106/419 - (25%)
Similarity:	169/419 - (40%)	Gaps:	102/419 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 NGKQEFAVLPKRTVVRPKKYKKRTKPAEPKV--RMS---------------RELLEQRKKQQEEY 316
            ||::|  |.|.:..  |:|.|:..:|::|::  |.:               .:.||..|
Human   114 NGEKE--VFPPKEA--PRKGKRGRRPSKPRLIPRQTSGGPICPDCGCTFPDHQALESHK------ 168

  Fly   317 DVIIAKFFTSVLPCAIC-------NLLVHNFTEMQRHHRLTHQVDPGYMMC--CGRKFTQRKVLA 372
               .|:......||..|       :|||        .||..|..:..| :|  ||::|:|||.|:
Human   169 ---CAQNLKKPYPCPDCGRRFSYPSLLV--------SHRRAHSGECPY-VCDQCGKRFSQRKNLS 221

  Fly   373 EHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMD---------------PAV----------K 412
            :|.::|.....:.|..|.:.|:.||.|.:|:..|..               |::          :
Human   222 QHQVIHTGEKPYHCPDCGRCFRRSRSLANHRTTHTGEKPHQCPSCGRRFAYPSLLAIHQRTHTGE 286

  Fly   413 LTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIIC 477
            ..::|..|::.|..:||:..|   :.:...|..:.|.:|.::|.:..:|.:| ..:|..|....|
Human   287 KPYTCLECNRRFRQRTALVIH---QRIHTGEKPYPCPDCERRFSSSSRLVSH-RRVHSGERPYAC 347

  Fly   478 DKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGEHRCH 542
            :.|..:...:..|.:||.|...:||.|      |..||...:....|..| :|.|.|.. .|.|.
Human   348 EHCEARFSQRSTLLQHQLLHTGEKPYP------CPDCGRAFRRSGSLAIH-RSTHTEEK-LHACD 404

  Fly   543 ICAK--VSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTF 605
            .|.:  ..|:..|..|.:   |..||.:.|.:|.|.|.:...|.:|...||||..:.|..|...|
Human   405 DCGRRFAYPSLLASHRRV---HSGERPYACDLCSKRFAQWSHLAQHQLLHTGEKPFPCLECGRCF 466

  Fly   606 FCSANMYKHRQRLHRAQYEADKNQPKPPN 634
                     |||...|.:   |..||.||
Human   467 ---------RQRWSLAVH---KCSPKAPN 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856
		C2H2 Zn finger	330..351	CDD:275368	7/27 (26%)
		C2H2 Zn finger	360..378	CDD:275368	9/19 (47%)
		LIM	361..>400	CDD:295319	14/38 (37%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		zf-C2H2_8	389..465	CDD:292531	19/100 (19%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	4/16 (25%)
		C2H2 Zn finger	477..498	CDD:275368	6/20 (30%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	5/22 (23%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	6/20 (30%)
ZNF689	NP_612456.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		KRAB	29..88	CDD:214630
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..146		11/35 (31%)
		C2H2 Zn finger	151..171	CDD:275368	3/28 (11%)
		COG5048	159..>466	CDD:227381	85/339 (25%)
		C2H2 Zn finger	179..199	CDD:275368	7/27 (26%)
		C2H2 Zn finger	207..227	CDD:275368	9/19 (47%)
		C2H2 Zn finger	235..255	CDD:275368	7/19 (37%)
		C2H2 Zn finger	263..283	CDD:275368	1/19 (5%)
		C2H2 Zn finger	291..311	CDD:275368	6/22 (27%)
		C2H2 Zn finger	319..339	CDD:275368	5/20 (25%)
		C2H2 Zn finger	347..367	CDD:275368	5/19 (26%)
		C2H2 Zn finger	375..395	CDD:275368	6/20 (30%)
		C2H2 Zn finger	403..423	CDD:275368	5/22 (23%)
		C2H2 Zn finger	431..451	CDD:275368	6/19 (32%)
		C2H2 Zn finger	459..475	CDD:275368	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910