DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4282 and ZBTB18

DIOPT Version :9

Sequence 1:NP_611118.3 Gene:CG4282 / 36825 FlyBaseID:FBgn0034114 Length:652 Species:Drosophila melanogaster
Sequence 2:NP_991331.1 Gene:ZBTB18 / 10472 HGNCID:13030 Length:531 Species:Homo sapiens


Alignment Length:623 Identity:115/623 - (18%)
Similarity:214/623 - (34%) Gaps:182/623 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 NQHFPVQISKESDERICGRCWKIVSDFH-TLHEFVSAAQSSLQETKVALMEDDPLTQETTSFPEI 102
            ::|....:|::..:.....|..:|.|.. ..|..|.|:.|..    ..|...|.|.:.     :|
Human    16 SRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMY----FHLFYKDQLDKR-----DI 71

  Fly   103 IKLATQEEEGVTEPQELGGRNFFYPEIKIEEHELDTLPRIEILERSANTQENQDQLEGAARRLRK 167
            :.|   ..:.||.|.......|.| |.|::..:|.    ||.:..:|:.....|.::...::|::
Human    72 VHL---NSDIVTAPAFALLLEFMY-EGKLQFKDLP----IEDVLAAASYLHMYDIVKVCKKKLKE 128

  Fly   168 RL--------KAEDGSSVDKDKDE---DGVEETAEPAPPKKRRGRPRKSDAAVAPPQKPKEDIQL 221
            :.        |.||.||. .||.|   ||....|...|..:..|...|.:  :.|.::       
Human   129 KATTEADSTKKEEDASSC-SDKVESLSDGSSHIAGDLPSDEDEGEDEKLN--ILPSKR------- 183

  Fly   222 DLKAEELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRPK 286
            ||.||..:.::          .:|||::.....|.:.             :..|....:||..|.
Human   184 DLAAEPGNMWM----------RLPSDSAGIPQAGGEA-------------EPHATAAGKTVASPC 225

  Fly   287 KYKKRTKPAEPKVRMSRELLEQRK----KQQEEYDVII---------------AKFFTSVLPCAI 332
            .              |.|.|.||.    :...:.|.::               :.:|:|.     
Human   226 S--------------STESLSQRSVTSVRDSADVDCVLDLSVKSSLSGVENLNSSYFSSQ----- 271

  Fly   333 CNLLVHNFTEMQRHHRLTHQVDPGYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSR 397
             ::|..|..:::                     .:::...:...|..|....:.|..::|...:.
Human   272 -DVLRSNLVQVK---------------------VEKEASCDESDVGTNDYDMEHSTVKESVSTNN 314

  Fly   398 HLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFL---TER 459
            .:: ::..|:.|               |.:.:: ..:|::....|:.:....|..:..:   .|.
Human   315 RVQ-YEPAHLAP---------------LREDSV-LRELDREDKASDDEMMTPESERVQVEGGMES 362

  Fly   460 KLKNHMSSMHDPESTI-ICDKCGKQMRTKIILKKH-------QELMHSDKPRPEPELQQCQICGA 516
            .|..::|::..|...| :|..|.|...:..||:.|       |:.:.| ||..:..:..|.:||.
Human   363 SLLPYVSNILSPAGQIFMCPLCNKVFPSPHILQIHLSTHFREQDGIRS-KPAADVNVPTCSLCGK 426

  Fly   517 WLKGMTGLKQHMKSIHVESAGEHRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQ 581
            ....|..||:|.::                               |..|:.:.||.|.|:|:...
Human   427 TFSCMYTLKRHERT-------------------------------HSGEKPYTCTQCGKSFQYSH 460

  Fly   582 ELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLH 619
            .|..|...||.|..:.|..|...|..|.::|:|.::.|
Human   461 NLSRHAVVHTREKPHACKWCERRFTQSGDLYRHIRKFH 498

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4282NP_611118.3 zf-AD 7..81 CDD:285071 9/42 (21%)
FYDLN_acid <191..268 CDD:302856 12/76 (16%)
C2H2 Zn finger 330..351 CDD:275368 2/20 (10%)
C2H2 Zn finger 360..378 CDD:275368 0/17 (0%)
LIM 361..>400 CDD:295319 4/38 (11%)
C2H2 Zn finger 386..406 CDD:275368 2/19 (11%)
zf-C2H2_8 389..465 CDD:292531 9/78 (12%)
C2H2 Zn finger 417..438 CDD:275368 2/20 (10%)
C2H2 Zn finger 448..465 CDD:275368 3/19 (16%)
C2H2 Zn finger 477..498 CDD:275368 7/27 (26%)
C2H2 Zn finger 511..532 CDD:275368 7/20 (35%)
C2H2 Zn finger 541..562 CDD:275368 0/20 (0%)
C2H2 Zn finger 570..590 CDD:275368 7/19 (37%)
C2H2 Zn finger 598..619 CDD:275368 6/20 (30%)
ZBTB18NP_991331.1 BTB 23..119 CDD:279045 25/112 (22%)
BTB 34..119 CDD:197585 24/101 (24%)
COG5048 <303..>490 CDD:227381 46/235 (20%)
C2H2 Zn finger 381..401 CDD:275368 6/19 (32%)
C2H2 Zn finger 421..441 CDD:275368 7/50 (14%)
zf-H2C2_2 434..456 CDD:290200 9/52 (17%)
C2H2 Zn finger 449..469 CDD:275368 7/19 (37%)
C2H2 Zn finger 477..495 CDD:275368 6/17 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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