DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and znf977

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_021331166.1	Gene:	znf977 / 103910561	ZFINID:	ZDB-GENE-110913-138	Length:	765	Species:	Danio rerio

Alignment Length:	365	Identity:	105/365 - (28%)
Similarity:	143/365 - (39%)	Gaps:	67/365 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   333 CNLLVH-------------NFT---EMQRHHRLTHQVDPGYMMCCGRKFTQRKVLAEHVLVHWNP 381
            |::.:|             :||   .:.:|.|:.....|.....||:.||....|.:|:.:|...
Zfish   335 CHMTIHTGQKPFTCTQCGKSFTCSSRLHQHMRIHTGEKPFTCTQCGKSFTCSSRLHQHMRIHTGE 399

  Fly   382 DHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYH------------- 433
            ..|.|:.|.|||..|.||..|.::|....:   |:|..|.|.|...:.::.|
Zfish   400 KPFSCTQCGKSFSQSSHLNQHMRIHNREKL---FTCTQCGKNFNQSSNLNQHMRIHTGEKPFTCT 461

  Fly   434 ----------KLNKH--VPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRT 486
                      .||.|  :...|..||||:|.|.|.....|..|| .:|..|....|.:|||....
Zfish   462 QCGKSFSQSSNLNLHMRIHTGEKPFTCSQCGKSFSQSSSLNLHM-RIHTGEKPFTCTQCGKSFSQ 525

  Fly   487 KIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGEH--RCHICAKVSP 549
            ..||..|......:||      ..|..||......|.|.|||: ||   .||:  .|..|.|...
Zfish   526 SSILNIHMRNHTGEKP------FTCLQCGKSFSQSTYLNQHMR-IH---TGENLFTCTQCGKSFS 580

  Fly   550 NARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMY-K 613
            |:..|..|: ..|..|:.|.||.|.|:|.:...|..|...||||..:||..|..:|  |.:.| .
Zfish   581 NSANLNLHM-RIHTGEKPFTCTQCGKSFSQSSNLNIHMRIHTGEKPFTCSQCGKSF--SQSPYLN 642

  Fly   614 HRQRLHRAQ-----YEADKNQPKPPNILKISRNASTQNKP 648
            |..|:|..:     .:..|:..|..| |.|.....|..||
Zfish   643 HHMRIHTGEKPFTCSQCGKSFSKSSN-LNIHMRIHTGEKP 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856
		C2H2 Zn finger	330..351	CDD:275368	6/33 (18%)
		C2H2 Zn finger	360..378	CDD:275368	6/17 (35%)
		LIM	361..>400	CDD:295319	15/38 (39%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		zf-C2H2_8	389..465	CDD:292531	27/100 (27%)
		C2H2 Zn finger	417..438	CDD:275368	7/43 (16%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	8/20 (40%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	7/21 (33%)
znf977	XP_021331166.1	COG5048	8..415	CDD:227381	20/79 (25%)
		C2H2 Zn finger	12..32	CDD:275368
		C2H2 Zn finger	40..60	CDD:275368
		C2H2 Zn finger	68..88	CDD:275368
		C2H2 Zn finger	96..116	CDD:275368
		C2H2 Zn finger	124..144	CDD:275368
		C2H2 Zn finger	152..172	CDD:275368
		C2H2 Zn finger	180..200	CDD:275368
		C2H2 Zn finger	208..228	CDD:275368
		C2H2 Zn finger	236..256	CDD:275368
		C2H2 Zn finger	264..284	CDD:275368
		C2H2 Zn finger	292..312	CDD:275368
		C2H2 Zn finger	320..340	CDD:275368	1/4 (25%)
		COG5048	343..756	CDD:227381	103/357 (29%)
		C2H2 Zn finger	348..368	CDD:275368	4/19 (21%)
		C2H2 Zn finger	376..396	CDD:275368	6/19 (32%)
		C2H2 Zn finger	404..424	CDD:275368	9/19 (47%)
		C2H2 Zn finger	432..452	CDD:275368	5/19 (26%)
		C2H2 Zn finger	460..480	CDD:275368	3/19 (16%)
		C2H2 Zn finger	488..508	CDD:275368	8/20 (40%)
		C2H2 Zn finger	516..536	CDD:275368	7/19 (37%)
		C2H2 Zn finger	544..564	CDD:275368	8/20 (40%)
		C2H2 Zn finger	572..592	CDD:275368	6/20 (30%)
		C2H2 Zn finger	600..620	CDD:275368	7/19 (37%)
		C2H2 Zn finger	628..648	CDD:275368	7/21 (33%)
		C2H2 Zn finger	656..676	CDD:275368	5/20 (25%)
		C2H2 Zn finger	684..704	CDD:275368
		C2H2 Zn finger	712..732	CDD:275368
		C2H2 Zn finger	740..760	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910