DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and si:cabz01032454.3

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_003198589.1	Gene:	si:cabz01032454.3 / 100534979	ZFINID:	ZDB-GENE-161017-73	Length:	499	Species:	Danio rerio

Alignment Length:	504	Identity:	135/504 - (26%)
Similarity:	194/504 - (38%)	Gaps:	119/504 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 QENQDQLEGAARRLRKRLKAEDGSSVDKDKDEDGVEETAEPAPPKKRRGRPRKSDAAVAPPQKPK 216
            :|::|            ||.||..:|   |.||                 |.:::..|.     |
Zfish     6 EESED------------LKIEDTFTV---KQED-----------------PEQTELMVL-----K 33

  Fly   217 EDIQLDLKAEELDEF---VDEETDPDFSCLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLP 278
            |:.|...:.:|.|:.   .|..||...||    ..|.:         :.|||......:.|...|
Zfish    34 EETQEMNEMKEKDQIETHQDLTTDEQSSC----KRSPK---------TKSDFICSQCGKGFNHQP 85

  Fly   279 K-------RTVVRP-------KKYKKRTKPAEPKVRMSRELLEQRKKQQEEYDVIIAKFFTSVLP 329
            .       .|..||       |.:.:..|   .||.|                    :..|...|
Zfish    86 NLIVHMRIHTGERPYSCDQCGKSFSQNEK---LKVHM--------------------RVHTKERP 127

  Fly   330 --CAICNLLVHNFTEMQR---HHRLTHQVDPGYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVC 389
              |..|.   .:||:.:.   |.|:.....|.....||::|:|...|.|||.:|.......|:||
Zfish   128 YTCPQCG---KSFTQKESLNVHIRVHTGEKPFPCQHCGKRFSQLHALKEHVTIHTGERPHACTVC 189

  Fly   390 EKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYH-KLN-KHVPKSEFK-FTCSEC 451
            .|:|.:.:.||.|..||....:   |.|..|.|.|..|.::..| ||: |..|.::.| :.|:||
Zfish   190 GKTFYHKQKLEKHMTVHTGEKL---FDCQQCGKRFGQKDSLRIHMKLHTKDKPHAKEKPYICTEC 251

  Fly   452 NKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGA 516
            :|.|.::..|.:||.: |..|....||:|||.......||.|..:...:||      ..|..||.
Zfish   252 DKAFASKSNLNHHMVT-HTGEKPFSCDECGKSFGQNSKLKVHMRVHTKEKP------YSCDQCGK 309

  Fly   517 WLKGMTGLKQHMKSIHVESAGEHRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQ 581
            .......||.||: :|.:.. .:.|..|.|.......|:.|| ..|..|:.|.|..|.|.|.:..
Zfish   310 SFSQNEKLKVHMR-VHTKER-PYTCPQCGKSFTQKENLKVHI-RVHTGEKPFPCQECGKRFMQLH 371

  Fly   582 ELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYEADKNQP 630
            .||||..|||||..:.||.|..| :|.    |.:.::|...:..:|..|
Zfish   372 VLKEHLRTHTGEKPFACPQCSKT-YCQ----KQKLKMHMTVHAKEKLFP 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	16/79 (20%)
		C2H2 Zn finger	330..351	CDD:275368	6/23 (26%)
		C2H2 Zn finger	360..378	CDD:275368	8/17 (47%)
		LIM	361..>400	CDD:295319	14/38 (37%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	26/78 (33%)
		C2H2 Zn finger	417..438	CDD:275368	8/22 (36%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	8/20 (40%)
		C2H2 Zn finger	511..532	CDD:275368	7/20 (35%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	8/19 (42%)
		C2H2 Zn finger	598..619	CDD:275368	6/20 (30%)
si:cabz01032454.3	XP_003198589.1	COG5048	52..481	CDD:227381	118/421 (28%)
		C2H2 Zn finger	74..94	CDD:275368	2/19 (11%)
		zf-H2C2_2	86..111	CDD:290200	4/24 (17%)
		C2H2 Zn finger	102..122	CDD:275368	5/42 (12%)
		zf-H2C2_2	115..139	CDD:290200	8/46 (17%)
		C2H2 Zn finger	130..150	CDD:275368	6/22 (27%)
		zf-H2C2_2	142..167	CDD:290200	6/24 (25%)
		C2H2 Zn finger	158..178	CDD:275368	8/19 (42%)
		C2H2 Zn finger	186..206	CDD:275368	8/19 (42%)
		C2H2 Zn finger	214..234	CDD:275368	7/19 (37%)
		C2H2 Zn finger	248..268	CDD:275368	8/20 (40%)
		zf-H2C2_2	260..283	CDD:290200	10/23 (43%)
		C2H2 Zn finger	276..296	CDD:275368	8/19 (42%)
		zf-H2C2_2	289..313	CDD:290200	8/29 (28%)
		C2H2 Zn finger	304..324	CDD:275368	7/20 (35%)
		zf-H2C2_2	317..341	CDD:290200	8/25 (32%)
		C2H2 Zn finger	332..352	CDD:275368	6/20 (30%)
		zf-H2C2_2	344..367	CDD:290200	9/23 (39%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	388..408	CDD:275368	7/24 (29%)
		C2H2 Zn finger	416..436	CDD:275368	135/504 (27%)
		C2H2 Zn finger	444..464	CDD:275368
		C2H2 Zn finger	472..492	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910