DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and znf408

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_002934125.2	Gene:	znf408 / 100493930	XenbaseID:	XB-GENE-960608	Length:	765	Species:	Xenopus tropicalis

Alignment Length:	594	Identity:	125/594 - (21%)
Similarity:	212/594 - (35%)	Gaps:	140/594 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 LQETKVA-LMEDDPLTQETTSFPEIIKLATQEEEGVTEPQELGGRNFFYPEIKIEEHELDTLPRI 142
            |.:||.| ::|...|  .|...|.::.:.|.:..|   |...|     .||
Frog   165 LSDTKDAEMLESSHL--PTVPLPSVMSVVTPQPNG---PSAAG-----TPE-------------- 205

  Fly   143 EILERSANTQ----ENQDQL----EGAARRL-RKRLKAEDGSSVDKDKDEDGVEETAEPAPPKKR 198
              .||:|:.:    ||...:    |||...: ...:.:..|.:            |..|.|..:|
Frog   206 --TERTASAEPAEKENLSPVITEPEGAKLLIGLHHMNSSAGCA------------TQGPVPNTER 256

  Fly   199 RGRPRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDFS----CLVPSDNSSEDDG----- 254
            ..:..:...|.            |:::|.:.|...:.:..:.|    ..|....||.|.|
Frog   257 ESQVTECSHAA------------DVRSESVTENALQMSQTNNSQHGVAAVGQSESSRDQGKKRER 309

  Fly   255 ------------------GSDGFDSDSDFELDNGKQEFAVLPKRTVVRPKKYKKRTKPAEPKVRM 301
                              |::..|:..|...:.|..:.:  |...:|..:..|.:.:|.
Frog   310 KKERNAPNWKSTASTRKKGAETTDTPVDARCEPGALQES--PNALIVNSENKKCKVQPQ------ 366

  Fly   302 SRELLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVDPGYMMCCGRKFT 366
                .|:|                  .||..|.........:::|..:...:.|.....||:.::
Frog   367 ----TERR------------------FPCKDCGRSFFQLGHLKKHSFIHSGLKPFLCTDCGKTYS 409

  Fly   367 QRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAID 431
            ..:....|:|.|.....|||.:|:|::...|.|..|..:|..   :..:.|:.|.|:|..:..:.
Frog   410 SEESFKGHLLSHMGLRPFKCQLCDKAYSTQRDLREHAVLHTG---QRPYRCEDCGKSFTRRPTLR 471

  Fly   432 YHKLNKHVPKSEFKF----TCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKK 492
            .|:.|.....:...|    .|..|.|.......|:||| .:|..:....|..||...|.|..|:.
Frog   472 IHRKNYCTSAATIDFKPSLECPVCKKMLANSCSLRNHM-RIHSGDKPFSCSDCGAAFRHKSSLRV 535

  Fly   493 HQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGE-HRCHICAKVSPNARALRR 556
            |:.|...:||      .:||.||........|::|:    :...|| :.|.:|.|...:...|:.
Frog   536 HKRLHTGEKP------YKCQYCGDAFPQQPELRRHL----IMHTGEMYLCTVCGKALKDPHTLKA 590

  Fly   557 HIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRA 621
            | ...|..||.|.|..|||::....:|:.|..:|..|..:.|..|.|.:....::.:| .|.|:.
Frog   591 H-ERLHTGERPFTCQYCEKSYPLATKLRRHLKSHLEEKPFRCHLCGMGYSLQPSLKRH-LRSHKD 653

  Fly   622 QYEADKNQP 630
            .:|  |.:|
Frog   654 GHE--KAEP 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	1/1 (100%)
		FYDLN_acid	<191..268	CDD:302856	16/103 (16%)
		C2H2 Zn finger	330..351	CDD:275368	3/20 (15%)
		C2H2 Zn finger	360..378	CDD:275368	4/17 (24%)
		LIM	361..>400	CDD:295319	11/38 (29%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		zf-C2H2_8	389..465	CDD:292531	18/79 (23%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	8/20 (40%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	5/20 (25%)
znf408	XP_002934125.2	SET	20..123	CDD:394802
		fibronec_FbpA	<133..317	CDD:411474	37/201 (18%)
		COG5048	347..>651	CDD:227381	80/349 (23%)
		C2H2 Zn finger	373..393	CDD:275368	3/19 (16%)
		C2H2 Zn finger	401..421	CDD:275368	4/19 (21%)
		C2H2 Zn finger	429..449	CDD:275368	6/19 (32%)
		C2H2 Zn finger	492..512	CDD:275368	7/20 (35%)
		C2H2 Zn finger	520..540	CDD:275368	7/19 (37%)
		C2H2 Zn finger	548..568	CDD:275368	6/23 (26%)
		C2H2 Zn finger	575..595	CDD:275368	5/20 (25%)
		C2H2 Zn finger	603..623	CDD:275368	6/19 (32%)
		C2H2 Zn finger	631..651	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910