DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and znf532

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_002936713.2	Gene:	znf532 / 100493656	XenbaseID:	XB-GENE-491148	Length:	1343	Species:	Xenopus tropicalis

Alignment Length:	906	Identity:	172/906 - (18%)
Similarity:	267/906 - (29%)	Gaps:	308/906 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 QLEVTTIV-----NQHFPVQISKE--SDERICGRCWKIV-------------------------- 62
            :|...||:     ||..|:..::|  .||:|     ::|
Frog   152 KLHTDTILKASSFNQFSPISSAEEFDEDEKI-----EVVDPPDREALKSSFSSNILDESGVEQVY 211

  Fly    63 -SD-FHTLHEFVSA--AQSSLQETKVALMEDDPLTQETTSF-----------PEIIK-------L 105
             || .|:...|:.|  |....|:...:...|  |...:|:|           .|.:|       |
Frog   212 ESDKMHSGDHFIKAGTALPGSQDKNKSSKRD--LEASSTNFSVYDTFKLQKLDEKLKESAQRLLL 274

  Fly   106 ATQEEEGV-TEPQELGGRNFFYPEIKIEEHELDTLPRIEILERSANTQENQDQLEGAARRLRKRL 169
            .|:|:|.: ||..|..|........|........:..|..|.......:.:| ||.::......|
Frog   275 ETKEDEKIDTEKSEANGGTISQLRAKSSAKLSSCIAAIAALSAKKTVCDLKD-LEPSSGGASPVL 338

  Fly   170 KAEDGS--SVDKDKDE--------DGVEETAEPAPPKKR--------RGRPRKSDAAVAPPQKPK 216
            |..|.|  |.||..|.        ||.::.........|        :|.|..|..:.  |..||
Frog   339 KEGDCSPMSADKSPDSQLTVQSLIDGTKKVQAKQSDSPRSVLSETSSKGSPSSSGGST--PAIPK 401

  Fly   217 EDIQL-----------------DLKAEELDEFVDEETDPDFSCLVPSDNS--------------- 249
            ..|:.                 |...|||.:.|:..:....|.|:||.:|
Frog   402 VRIKTIKTSSGEIKRMVTRVLPDFDVEELKKNVEPNSPVLVSSLLPSPSSTPVLSSPTRASLHPS 466

  Fly   250 ------SED----------------------DGGSDGFD----------------------SDSD 264
                  |.|                      ..||...:                      |.:.
Frog   467 IGSPVASTDVAPKQVTIKPVATAFLPVSAVKTAGSQVINLKFGNNTTVKATVISAASVQSASSAI 531

  Fly   265 FELDNG-KQEFAVLPKRTVVRPKKYKKRTKPAE----PKVRMSRELLE-QRKKQQEEYDVIIAKF 323
            .:..|. :|:..|:|..::...|...|....|.    |:...:.||.: ..|.||:....::|..
Frog   532 IKAANAIQQQTVVVPASSLANTKLVPKTVHFANLNLLPQGSQTSELRQVLAKPQQQIKQALVAAA 596

  Fly   324 FTSVLPCAICNLLV---HNFTEMQRHHRLTHQVDP---------------------GYMMC--CG 362
            ..|..|..:..:.|   ...:.::..:::...|:|                     || .|  ||
Frog   597 TPSTPPKKVSRVQVVASSQSSVVEAFNKVLSSVNPLPVYVPNLTPPASAGITLPTRGY-KCLECG 660

  Fly   363 RKFTQRKVLAEHVLVHWNPDHFKCSVCEKS--FQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFL 425
            ..|...|.|.:|...........|:.|.|:  |.|...|.||.:.|.:..|.:.     ||...|
Frog   661 DAFALEKSLLQHYDRRSVRIEVTCNHCSKNLVFYNKCSLLSHARGHKEKGVVMQ-----CSHLIL 720

  Fly   426 -------------------------SKTAIDYHKLNK--------------------HVPKSE-- 443
                                     :..|:..|.:.|                    .:|..|
Frog   721 KPVPTDQMIVASQNNASTTPLATRQTPVAVVAHTVTKIQPGLPGPVISAPSNTPVAPAMPLDEDP 785

  Fly   444 -----FKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPR 503
                 ....|.||::.|..|..|..|.....|..:...|..|...:........||.:.....|.
Frog   786 ANLCRHSLKCLECSEVFQDEIALATHYQQASDATAQKTCSICMMLLPNPCSYNCHQRIHQHKSPY 850

  Fly   504 PEPEL-------------------------QQCQICGAWLKGMTGLKQHMKSIHVESAGEHRCHI 543
            ..||.                         .:|..|......::.||.|::..|.|..  ::|.|
Frog   851 TCPECGAICRSVHFQTHVTKNCLHYTRRVGYRCLHCSVVYSELSALKCHIQGSHCEVF--YKCPI 913

  Fly   544 CAKVSPNARALRRHIYHNH------ECERKFKCTMCEKAFKRPQELKEHTSTHTGE---VLYTCP 599
            |.....:|.:...|.|..|      |.:..:||:||:..|.....|..|...|...   .::.||
Frog   914 CPMAFKSAPSTHSHAYTQHPGVKIGEPKIIYKCSMCDTVFTLQPLLHRHFDQHLENQKVSVFKCP 978

  Fly   600 NCPMTFFCSANMYKHRQRLHRAQYEADKNQPKPPNI---LKISRNASTQN-------KPKQ 650
            :|.:.:.....|..|.:.:|...    |:...||.:   |.:|...:|||       .|||
Frog   979 DCSLLYAQKQLMMDHIKSMHGTL----KSIEGPPKLGVNLPLSTKPTTQNATSSSKEDPKQ 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	17/86 (20%)
		FYDLN_acid	<191..268	CDD:302856	23/166 (14%)
		C2H2 Zn finger	330..351	CDD:275368	1/23 (4%)
		C2H2 Zn finger	360..378	CDD:275368	7/19 (37%)
		LIM	361..>400	CDD:295319	11/40 (28%)
		C2H2 Zn finger	386..406	CDD:275368	8/21 (38%)
		zf-C2H2_8	389..465	CDD:292531	23/129 (18%)
		C2H2 Zn finger	417..438	CDD:275368	6/65 (9%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	4/20 (20%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	5/20 (25%)
znf532	XP_002936713.2	C2H2 Zn finger	795..821	CDD:275368	8/25 (32%)
		C2H2 Zn finger	824..844	CDD:275368	4/19 (21%)
		C2H2 Zn finger	852..874	CDD:275368	2/21 (10%)
		C2H2 Zn finger	883..900	CDD:275368	4/16 (25%)
		C2H2 Zn finger	911..932	CDD:275368	6/20 (30%)
		C2H2 Zn finger	946..966	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1068..1088	CDD:275368
		C2H2 Zn finger	1098..1119	CDD:275368
		C2H2 Zn finger	1128..1148	CDD:275368
		C2H2 Zn finger	1218..1238	CDD:275368
		zf-C2H2_11	1241..1269	CDD:406917
		C2H2 Zn finger	1247..1268	CDD:275368
		C2H2 Zn finger	1308..1328	CDD:275368
		zf-C2H2_6	1308..1328	CDD:404748
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910