DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and znf423

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_002937417.2	Gene:	znf423 / 100491000	XenbaseID:	XB-GENE-490169	Length:	1289	Species:	Xenopus tropicalis

Alignment Length:	684	Identity:	140/684 - (20%)
Similarity:	222/684 - (32%)	Gaps:	229/684 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 IKIEEHELDTLPRIEILERSANTQENQDQLEGAARRLRKRLKA-EDGSSVDKDKDEDGVEETAEP 192
            :|:|:.|          :...|.:....|..|..|...:..:. |||:||  ...|:.:||
Frog    12 VKVEDSE----------DFGLNWESTVTQAGGLDREAEEEGQTLEDGNSV--TSHEERIEE---- 60

  Fly   193 APPKKRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDE------FVDEETDPDFSCLVPSDNSSE 251
                     ....|.::......::|..   ...||.|      ..|.:.||.|| .|||..||:
Frog    61 ---------EELEDESIYTCDNCQQDFD---SLAELTEHRTQHCLGDGDDDPQFS-WVPSSPSSK 112

  Fly   252 DDGG-----SDGFDSDSDFELDNGKQE-FAVLPKRTVVRPKKYKKRTKPAEPKVRMSRELLEQRK 310
            |...     .||.|      |..|::| .:.||.......|.:.:               |...|
Frog   113 DIASPTQIIGDGCD------LGIGEEEGGSGLPYPCQFCDKSFSR---------------LSYLK 156

  Fly   311 KQQEEYDVIIAKFFTSVLP--CAICNLLVHNFTEMQRHHRLTHQVDPGYMMC--CGRKFTQRKVL 371
            :.::        ..:..||  |..|:.|..:.....||.:| |..|..| .|  |...|::...|
Frog   157 RHEQ--------IHSDKLPFKCTYCSRLFKHKRSRDRHIKL-HTGDKKY-HCHECEAAFSRSDHL 211

  Fly   372 AEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLT----------FSCDLCSKTFLS 426
            ..|:..|.:...|||:||::.|.::..|:||.|.|......:|          |.||.|.:||..
Frog   212 KIHLKTHSSSKPFKCTVCKRGFSSTSSLQSHMQAHRKNKEYMTKSDREMKKDDFMCDYCEETFSQ 276

  Fly   427 KTAIDYHKLNKHVPKSE-FKFTCSECNKKFLTERKLKNHMSSMH--------------------- 469
            ...::.|.:.:|...|| ....|..|.:.|..|..|..|:..:|
Frog   277 TEDLEKHVMTRHPQLSEKADLQCIHCPEVFADETSLLTHIDHVHANKKHKCPMCPEQFSSVEEVY 341

  Fly   470 -------------------------------------------DPESTI---------------- 475
                                                       .|:||:
Frog   342 CHLDSHRQPDSSNHSISPDPVLGSVASMSSATPDSSASLERASTPDSTLKPIRGHKRTGSFDRED 406

  Fly   476 ---------ICDKCGKQ-MRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKS 530
                     .|..|.|: ..:..:|:.|.:.:|.|||:   :...||||...|..:..|.:|::.
Frog   407 ERNWPKITYSCPYCSKRDFNSLAVLEIHLKTIHVDKPQ---QNHTCQICLDSLPTLYNLNEHVRK 468

  Fly   531 IHVESA---------GEHRCHICAKVSPNARALRRHIYHNH--------ECERKFKCTMCEKAFK 578
            :|...|         ....|:.|.::..:..:|:.||...|        |....|.|..|...|.
Frog   469 VHKNHAYPMVQFSNITAFHCNYCPEMFADINSLQEHIRVTHCGPNATTQEGNNAFFCNQCSMGFL 533

  Fly   579 RPQELKEH-TSTHTG------------------EVLYTCPNCPMT--FFCSANMYKHRQRLHR-- 620
            ....|.|| ..||..                  || |:||.|..:  |.....:.||.:..|:
Frog   534 TESSLTEHIQQTHCNVGSSKLESPVIQPTQSFMEV-YSCPYCTNSPIFGSILKLTKHIKENHKNI 597

  Fly   621 --AQYEADKNQPKPPNILKISRNASTQNKPKQEI 652
              |.::..|::..|     :|.:....:..:|.:
Frog   598 PLANHKKSKSEQSP-----VSSDVEVSSPKRQRL 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	19/87 (22%)
		C2H2 Zn finger	330..351	CDD:275368	6/20 (30%)
		C2H2 Zn finger	360..378	CDD:275368	5/19 (26%)
		LIM	361..>400	CDD:295319	11/38 (29%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	23/86 (27%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	5/21 (24%)
		C2H2 Zn finger	511..532	CDD:275368	7/20 (35%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	6/20 (30%)
		C2H2 Zn finger	598..619	CDD:275368	6/22 (27%)
znf423	XP_002937417.2	COG5048	<141..246	CDD:227381	30/129 (23%)
		C2H2 Zn finger	142..162	CDD:275368	3/42 (7%)
		C2H2 Zn finger	170..190	CDD:275368	6/20 (30%)
		COG5048	196..601	CDD:227381	83/409 (20%)
		C2H2 Zn finger	198..218	CDD:275368	5/19 (26%)
		C2H2 Zn finger	226..246	CDD:275368	8/19 (42%)
		C2H2 Zn finger	267..286	CDD:275368	6/18 (33%)
		C2H2 Zn finger	299..316	CDD:275368	5/16 (31%)
		C2H2 Zn finger	417..438	CDD:275368	5/20 (25%)
		C2H2 Zn finger	449..470	CDD:275368	7/20 (35%)
		C2H2 Zn finger	488..509	CDD:275368	5/20 (25%)
		C2H2 Zn finger	525..546	CDD:275368	6/20 (30%)
		C2H2 Zn finger	640..660	CDD:275368
		C2H2 Zn finger	670..690	CDD:275368
		C2H2 Zn finger	700..717	CDD:275368
		C2H2 Zn finger	728..749	CDD:275368
		C2H2 Zn finger	758..779	CDD:275368
		C2H2 Zn finger	789..809	CDD:275368
		C2H2 Zn finger	815..833	CDD:275368
		C2H2 Zn finger	893..914	CDD:275368
		C2H2 Zn finger	937..957	CDD:275368
		C2H2 Zn finger	966..986	CDD:275368
		C2H2 Zn finger	1205..1225	CDD:275368
		C2H2 Zn finger	1236..1257	CDD:275368
		C2H2 Zn finger	1266..1282	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910