DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and znf628

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_002941933.2	Gene:	znf628 / 100489381	XenbaseID:	XB-GENE-5996090	Length:	1095	Species:	Xenopus tropicalis

Alignment Length:	427	Identity:	103/427 - (24%)
Similarity:	145/427 - (33%)	Gaps:	141/427 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   330 CAICNLLVHNFTEMQRHHRLTHQVDPGYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQ 394
            |.:|.....|.:.::||..:.....|.....||:.|||...|.:|..:|.....:||..|.|||.
Frog   146 CNVCEKAFKNSSSLRRHRNIHTGERPYECAICGKAFTQSTNLRQHQRIHTGERPYKCEDCGKSFT 210

  Fly   395 NSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKH--------------------V 439
            :|.:|..||:.|   :..::..|::|.|.|:|.:.:..| |..|                    |
Frog   211 HSSNLLLHQRTH---SAGVSHKCEICGKVFISDSFLQKH-LQSHAIEQAFVHAEAEVYLTTTAAV 271

  Fly   440 PKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMH-SDKP- 502
            ...|..|.|.:|...|..|..|..|..:  ..|....|..|.|..:....|.:|.:..| |::|
Frog   272 ETVEMVFKCGDCEMTFKNEDLLLGHQQT--HVEQIYPCTNCDKTFKNPSGLSRHNQHCHSSERPF 334

  Fly   503 -------------------RPEPELQQ----------------------------------CQIC 514
                               |...|.||                                  |..|
Frog   335 KCSICEKTFVQLSNLLVHQRTHTEEQQFIQTEAEVTCPQTSEIIQPSTATPATETVDRQYKCTEC 399

  Fly   515 GAWLKGMTGLKQHMK-----------------------SIHV----------------------- 533
            |...||.:||:.||:                       |||.
Frog   400 GKVFKGTSGLRYHMRDHTGERPYKCSECGKAFKRSSLLSIHQRVHTGVRAFKCAECGLTFKWSSH 464

  Fly   534 ------ESAGE--HRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTH 590
                  :..||  :.|..|.|...|...|||| ...|..||.|.|.||.|.|.:...|::|..||
Frog   465 YQYHLRQHTGERPYTCTDCGKSFKNTSCLRRH-RQLHTGERPFTCLMCGKTFTQTSNLRQHERTH 528

  Fly   591 TGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYEADK 627
            |||..|.|..|..:|..|:|:     :||:..:.:||
Frog   529 TGERPYKCDKCDKSFTHSSNL-----QLHQRTHSSDK 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856
		C2H2 Zn finger	330..351	CDD:275368	5/20 (25%)
		C2H2 Zn finger	360..378	CDD:275368	7/17 (41%)
		LIM	361..>400	CDD:295319	15/38 (39%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		zf-C2H2_8	389..465	CDD:292531	25/95 (26%)
		C2H2 Zn finger	417..438	CDD:275368	7/20 (35%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	5/20 (25%)
		C2H2 Zn finger	511..532	CDD:275368	10/43 (23%)
		C2H2 Zn finger	541..562	CDD:275368	8/20 (40%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	5/20 (25%)
znf628	XP_002941933.2	C2H2 Zn finger	34..54	CDD:275368
		zf-H2C2_2	46..70	CDD:404364
		C2H2 Zn finger	62..82	CDD:275368
		zf-H2C2_2	74..99	CDD:404364
		C2H2 Zn finger	90..110	CDD:275368
		C2H2 Zn finger	118..138	CDD:275368
		COG5048	142..576	CDD:227381	103/427 (24%)
		C2H2 Zn finger	146..166	CDD:275368	5/19 (26%)
		C2H2 Zn finger	174..194	CDD:275368	7/19 (37%)
		C2H2 Zn finger	202..222	CDD:275368	9/19 (47%)
		C2H2 Zn finger	230..250	CDD:275368	7/20 (35%)
		C2H2 Zn finger	280..300	CDD:275368	6/21 (29%)
		C2H2 Zn finger	307..328	CDD:275370	5/20 (25%)
		C2H2 Zn finger	336..356	CDD:275368	1/19 (5%)
		C2H2 Zn finger	396..416	CDD:275368	9/19 (47%)
		C2H2 Zn finger	424..444	CDD:275368	3/19 (16%)
		C2H2 Zn finger	452..472	CDD:275368	0/19 (0%)
		C2H2 Zn finger	480..500	CDD:275368	8/20 (40%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	536..556	CDD:275368	7/24 (29%)
		C2H2 Zn finger	564..584	CDD:275368
		SP1-4_N	<586..>840	CDD:425404
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910