DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and LOC100487439

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_031750845.1	Gene:	LOC100487439 / 100487439	-ID:	-	Length:	918	Species:	Xenopus tropicalis

Alignment Length:	817	Identity:	173/817 - (21%)
Similarity:	255/817 - (31%)	Gaps:	286/817 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 ISKESDERICGRCWKIVSD-FHTLHEFVS------AAQSSLQETKVALMEDDPLTQETTSFPEII 103
            :.||:.|:|.    :::|: .|.|...|:      |...|::|.:. :.|::.|
Frog   101 LQKENSEKIL----ELISNIIHLLTGEVAIRCEDVAVYFSMEEWEY-IRENEAL----------- 149

  Fly   104 KLATQEEEGVTEPQELGGRNFFYPEIK-------------------------IEEHELDTLPRIE 143
             ...:.:|.|.:...||..|....|||                         |..|...|.|...
Frog   150 -YTGESKENVQQRPPLGCTNEASDEIKAAPEAELPPSNNPGLCTDGNITNTDISMHPAPTEPSPL 213

  Fly   144 ILERSANTQENQDQLEGAARRLRKRLKAEDGSSVDKD----------KDE-----------DGVE 187
            ..|||      |..|..:..|.::::...:|.|.:||          |:|           |.||
Frog   214 YDERS------QSDLSISELREQRQVMPAEGCSRNKDLPGNSTPSSIKEEYSLRGAEAHCDDRVE 272

  Fly   188 ETAE----PAPPKKRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDEF-VDEETDPDFSCLVPSD 247
            ...|    |..|....|....:|.|.:..|             |.|.: ::.::|.....|..:|
Frog   273 ALTEQVGRPYTPSPAMGCSLDNDTANSIKQ-------------ETDSWDIESQSDCGSEALTGTD 324

  Fly   248 NSSEDDGGSD-------------------------------------GFDSDSD----FELDNGK 271
            .||...|.|.                                     |.|:.||    ...:.|.
Frog   325 TSSYGLGHSQSNSDTLLSSPGVRDKAVSCKGAKQSHSTVSKRTGLIHGIDTSSDTLASLYTEEGN 389

  Fly   272 QEFAV-------------------------LPKRTV------------VRPKKY----------K 289
            |....                         ||:.|:            ..|.||          .
Frog   390 QSDCSTNAHTEPTTGTDPSACVGGCSVNTGLPEYTINTSAYASHPGTDASPGKYTFDGYQKPFID 454

  Fly   290 KRTKPAEPKVRMSRE----------LLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQ 344
            .|.:..|.|:.:..|          |:..::....|      |.| |.|.|.  ....||:. :.
Frog   455 TRNQNTEEKLYVCHECGKSFSHNYLLVRHQRNHSGE------KPF-SCLECG--KSFTHNYL-LM 509

  Fly   345 RHHRLTHQVDPGYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDP 409
            ||.|......|.....||:.|||...|..|...|.....|.||.|.|.|....:|..|.:||..
Frog   510 RHQRYHTGERPFSCSECGKCFTQVSQLNYHQKSHTGEKPFTCSKCGKCFAYRSYLIIHHRVHTG- 573

  Fly   410 AVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPEST 474
              :..|:|..|.|.|.....:..|:.|....|:   |.||:|.|.:....:|.||..: |..|..
Frog   574 --EKPFTCTECGKCFTHNYLLVRHRKNHSQEKA---FACSDCGKSYTHPSQLANHQRN-HAREKP 632

  Fly   475 IICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKS--------- 530
            ..|.:|||......:|.:||:....:||      ..|..|......|:.|..|:|.
Frog   633 YTCTECGKCFSHNYLLLRHQKNHSGEKP------FACSKCDRCFAQMSQLNYHLKGHTGEKPFPC 691

  Fly   531 --------------IHVES-AGE--HRCHICAKVSPNARALRRHI-YHN-------HECERKF-- 568
                          ||..: .||  ::|..|.|...:...|..|: :|.       .||.::|
Frog   692 PKCGKRFAYHSQLLIHDRTHTGERPYKCMECGKCFTSRSHLNVHLQFHTGEKPFPCTECGKRFTR 756

  Fly   569 -----------------KCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQ 616
                             .|::|.|:|....:|.||...|.|..|:.|..|.: :|.|.::.....
Frog   757 RSHLSLHYRFHGGEGGYSCSICGKSFSLHSQLNEHLQLHAGAALFKCSECDI-YFKSRSVLLEHY 820

  Fly   617 RLHRAQ-----YEADKNQPK------------PPNIL 636
            |.|..:     .|.||..|.            .||||
Frog   821 RFHTGEKMFYCSECDKCFPSRSQLIVHYRVHMGPNIL 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	10/41 (24%)
		FYDLN_acid	<191..268	CDD:302856	20/122 (16%)
		C2H2 Zn finger	330..351	CDD:275368	6/20 (30%)
		C2H2 Zn finger	360..378	CDD:275368	7/17 (41%)
		LIM	361..>400	CDD:295319	14/38 (37%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		zf-C2H2_8	389..465	CDD:292531	22/75 (29%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	6/43 (14%)
		C2H2 Zn finger	541..562	CDD:275368	6/28 (21%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	5/20 (25%)
LOC100487439	XP_031750845.1	KRAB_A-box	126..>142	CDD:413388	3/15 (20%)
		COG5048	457..892	CDD:227381	104/425 (24%)
		C2H2 Zn finger	467..487	CDD:275368	2/19 (11%)
		C2H2 Zn finger	495..515	CDD:275368	7/22 (32%)
		C2H2 Zn finger	523..543	CDD:275368	7/19 (37%)
		C2H2 Zn finger	551..571	CDD:275368	7/19 (37%)
		C2H2 Zn finger	579..599	CDD:275368	5/19 (26%)
		C2H2 Zn finger	607..627	CDD:275368	7/20 (35%)
		C2H2 Zn finger	635..655	CDD:275368	7/19 (37%)
		C2H2 Zn finger	663..683	CDD:275368	6/19 (32%)
		C2H2 Zn finger	691..711	CDD:275368	2/19 (11%)
		C2H2 Zn finger	719..739	CDD:275368	5/19 (26%)
		C2H2 Zn finger	747..767	CDD:275368	3/19 (16%)
		C2H2 Zn finger	775..795	CDD:275368	7/19 (37%)
		C2H2 Zn finger	831..851	CDD:275368	4/19 (21%)
		C2H2 Zn finger	859..879	CDD:275368
		C2H2 Zn finger	887..907	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910