DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and zbtb20

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_017946862.1	Gene:	zbtb20 / 100302397	XenbaseID:	XB-GENE-993556	Length:	751	Species:	Xenopus tropicalis

Alignment Length:	668	Identity:	124/668 - (18%)
Similarity:	221/668 - (33%)	Gaps:	168/668 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 DYIDVHSARGDQLEVTTIVNQHFPVQISKESDERICGRCWKIVSDFHTLHEFVSAAQSSLQETKV 84
            :|:..|.    |..|..|.:..:...:...|.||                .|.|.|..|..:|.:
Frog   157 NYLQSHR----QHSVDRIYSALYTCSMHNGSGER----------------SFYSGALVSHHKTAL 201

  Fly    85 AL-----MEDD-----------------PLTQETT---SFPEIIKLATQEEEGVTEPQELGGRNF 124
            .|     ||:.                 ..|.|||   ..|..:::           |.|.|...
Frog   202 GLPRQHHMEEPSWITRIHQRSQRMERYLSATPETTHCRKQPRPVRI-----------QTLMGNIH 255

  Fly   125 FYPEIKIEEHELDTLPRIEILERSANTQ--ENQDQLEGAARRLRKRLKAEDGSSVDKDKDEDGVE 187
            ...|:: ::::.......:.|||:.:.:  |:.||.||.... .|....:.|.|.....:.|..|
Frog   256 IKQEVE-DDYDYYGQQSSQALERNESEECTEDTDQAEGTESE-PKGESFDSGVSSSIGTEPDSGE 318

  Fly   188 ETAEPAPPKKRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDFSCLVPSDNSSED 252
            :  :..|...|.|           ||:|.:       ||..:...:...:.|...|..|.:|.|.
Frog   319 Q--QYMPILSREG-----------PQEPSQ-------AESNNLPTEGSENQDQPHLETSSSSPER 363

  Fly   253 DGGSDGFDSDSDF-----ELDNGKQEFAVLPK--RTVVRPKKYKKRTKPAEPKVRMSRELLEQRK 310
            :     .|:||..     ..|.|..:.:|...  :|:...:.|.::|:.....:||...|....:
Frog   364 N-----LDTDSTVLRVSNSTDKGVVQTSVTQSIAQTMPNTQLYLRQTETLTSNLRMPLTLTSNTQ 423

  Fly   311 KQQEEYDVIIAKFFTS------------VLPCAICNLLVHNFT-----------EMQRHHRLTHQ 352
            ......:..:...||:            .||.:|........|           :.|...:.:|.
Frog   424 VIGTAGNTYLPTLFTTQAAGSGPKPFLFSLPQSIPGQQTQFVTVPQSGISPFAGQYQNTSQTSHS 488

  Fly   353 VD-------PGYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPA 410
            ..       |.....|.:.||.::...:|:.||......:||:|.:||....:|..|...|  ..
Frog   489 TSSAQGEKKPYECTLCNKTFTAKQNYVKHMFVHTGEKPHQCSICWRSFSLKDYLIKHMVTH--TG 551

  Fly   411 VKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHD----- 470
            |: .:.|.:|:|.|..|::::.| :..|  :.|..:.|..|.|||..:..|:.|: ::|.
Frog   552 VR-AYQCSICNKRFTQKSSLNVH-MRLH--RGEKSYECYICKKKFSHKTLLERHV-ALHSATNGT 611

  Fly   471 --------PESTIICDKCGKQMRTKII--LKKHQELMHSDKPRPEPELQQCQI---------CGA 516
                    |..::......:.:.:..|  ....|.|..:....|.|.|...|:         ..|
Frog   612 ASLPITAAPPGSVPAPGSAQPLGSAPISGTTPGQGLPPTPNMAPTPVLANAQVLPAAPVLAPASA 676

  Fly   517 WLKG---MTGLKQHMKSIHVESAGEHRCHICAKVSPN---ARALRRHIYHNHECERKFKCTMCEK 575
            .::.   ::.|......:|..:.......:.|...||   |.......|         .|::|..
Frog   677 LVQAPVLVSALAPTPNLVHPPTPSPTPGPVLAPRPPNGGVATGAEGTTY---------VCSVCPT 732

  Fly   576 AFKRPQELKEHTSTHTGE 593
            .|.:.::..:|...|..:
Frog   733 KFDQIEQFNDHMRMHVSD 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	12/60 (20%)
		FYDLN_acid	<191..268	CDD:302856	16/81 (20%)
		C2H2 Zn finger	330..351	CDD:275368	3/31 (10%)
		C2H2 Zn finger	360..378	CDD:275368	4/17 (24%)
		LIM	361..>400	CDD:295319	11/38 (29%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		zf-C2H2_8	389..465	CDD:292531	21/75 (28%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	3/22 (14%)
		C2H2 Zn finger	511..532	CDD:275368	3/32 (9%)
		C2H2 Zn finger	541..562	CDD:275368	5/23 (22%)
		C2H2 Zn finger	570..590	CDD:275368	4/19 (21%)
		C2H2 Zn finger	598..619	CDD:275368
zbtb20	XP_017946862.1	BTB_POZ_ZBTB20_DPZF	6..122	CDD:349517
		SEEEED	272..369	CDD:373302	27/122 (22%)
		zf-C2H2	499..521	CDD:333835	4/21 (19%)
		C2H2 Zn finger	501..521	CDD:275368	4/19 (21%)
		zf-C2H2	527..549	CDD:333835	7/21 (33%)
		C2H2 Zn finger	529..549	CDD:275368	7/19 (37%)
		zf-H2C2_2	541..566	CDD:372612	8/27 (30%)
		zf-C2H2	555..577	CDD:333835	6/22 (27%)
		C2H2 Zn finger	557..577	CDD:275368	6/20 (30%)
		zf-H2C2_2	569..594	CDD:372612	8/27 (30%)
		C2H2 Zn finger	585..605	CDD:275368	7/20 (35%)
		PRK14959	<606..>691	CDD:184923	10/84 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910