DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and sall1b

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_005163246.1	Gene:	sall1b / 100149526	ZFINID:	ZDB-GENE-020228-3	Length:	1203	Species:	Danio rerio

Alignment Length:	934	Identity:	173/934 - (18%)
Similarity:	279/934 - (29%)	Gaps:	377/934 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLCMCEYPAMMGD-YIDVHSARGDQLEVTTIV----NQHFPVQ---ISKESDERICGRCWKIVSD 64
            ||.:|:..|:..: :|       :.||.|.:.    :|..|::   |:..:.:::         |
Zfish   148 LLELCKLSAINSNVFI-------ENLENTKVAVAQFSQETPLKTSCINASNAKKV---------D 196

  Fly    65 FHTLHEFVSAAQSSLQETKVALMED--------------DPLTQETTSFPE---IIKLATQEEEG 112
            ...:.:.::..|..:|:.|  |:|:              .|||..:....:   :|||::|..|.
Zfish   197 LGLIEQLLALQQQQMQQLK--LIEEIRAQIMLLATQNSKTPLTTNSNGLSQTRSLIKLSSQLSEQ 259

  Fly   113 VTEPQELGGRNFFYPEIKIEEHELDTLPRIEILERSANTQ-----ENQDQLEGAARRLRKRLKAE 172
            :|....|.                      |.|..:|...     :|||.|.|.....:...|..
Zfish   260 LTAAAGLA----------------------ENLAANAKQSTHVIPQNQDGLRGEKEDSKVTSKIR 302

  Fly   173 DGSSVDK-DKDEDGVE-----------------ETAEPAP-----------PKK----------- 197
            |.|...| |.|:.|.:                 :|..|:|           |.|
Zfish   303 DDSLPMKLDIDQSGNQSLHDSKVTNKVDGGANLKTPSPSPASDGIVNKLELPHKPNSFNISANSL 367

  Fly   198 -------------------RRGRPRKSDAAVAPPQKPKED-------------------IQLDLK 224
                               |:.:|  .:.::...::|.||                   :|:.|:
Zfish   368 PSIGAIVEDLNALTALAQHRKAKP--VNVSLCEHKRPSEDCIFKHKCRFCAKVFGSDSALQIHLR 430

  Fly   225 A--------------------------------------------EELDEFVDEETDPDFSCLVP 245
            :                                            |.||..:.....| :...||
Zfish   431 SHTGERPYKCNICGNRFSTRGNLKVHFQRHKEKYPNVLMNPYPVPEHLDNVLTSTGIP-YGMSVP 494

  Fly   246 SD-------NSSEDDGGSDGFDSDSDF-------------------------ELD---NGKQE-F 274
            .:       :|....|.|.||...|..                         ||.   ||.|| |
Zfish   495 QEKPPLSWLDSKPLVGNSIGFMLSSSLPGLPVIIKKEEEGVSITKPHSPVVSELTKRINGHQEGF 559

  Fly   275 AVLPKRTVVRPKKYKK--RTKPAEPKVRMSRE---------------LLEQRKKQQEEYDVIIAK 322
            ...|  .::..:|:::  :.......:|.|||               |:.:.|.:|.|     ||
Zfish   560 VCSP--PIISNEKFQEVNQRLSVSTLLRSSREGSREDIAINTSVNTGLITKLKSEQLE-----AK 617

  Fly   323 FFTSVLPCAICNLLVHNFTEMQRHHRLTHQVDPGYM---MC--CGRKFTQRKVLAEHVLVHWNPD 382
            |....||..:      ..:|..:..:|...:|..|.   .|  |.|..:.:..|..|...|....
Zfish   618 FLLGSLPNPL------GASETAKLEQLVENIDKKYTDPNECGICHRVLSCQSALKMHFRTHTGER 676

  Fly   383 HFKCSVCEKSFQNSRHLESHQQVHMD-PAVKLTFSCDLCSKTFLSKTAIDYH---KLNKHVPKSE 443
            .|||.||.::|....:|::|..:|.. |.:::..||.:|.:.|.:...:..|   .:..|:|...
Zfish   677 PFKCRVCGRAFTTKGNLKTHYSIHRSMPPLRIQNSCPICQEKFTNAMVLQQHIHMHMGGHIPNVP 741

  Fly   444 FKFTCSECNKKFLTE----------------RKLKN----HMSSMHDPESTIICDKCGKQMR--- 485
            ...:..|...:.|.|                ..|||    ..|....|.|::.. :...|::
Zfish   742 MHDSSEELMDQDLVESMDTFPNEDTDTMQGASDLKNPDSLTESECSSPASSVFA-RSESQIKVTN 805

  Fly   486 -------TKIILK-------------KHQELMHSDKPRPEPELQQCQICGAW------------- 517
                   :|::::             ..|.:.|....|..|.    :...:|
Zfish   806 VENLENTSKLVIQDGSIEGDCLTQGLASQNIEHESLRRRIPS----ESTASWSPSSPKGYTTIDP 866

  Fly   518 ---------------LKGMTG------LKQHMKSIHVESAGEHRCHICAKVSPNARALRRHIYHN 561
                           |.|.:|      |......|:..|...:.|.||.|:.....||..| |.:
Zfish   867 KSAESNNSNLTVSRLLDGASGEVQKDTLTMVFPYINQGSLKSNVCDICNKMFACQSALDIH-YRS 930

  Fly   562 HECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYEAD 626
            |..||.|.||.|.|.|.....||:|..||....|      |...|..||
Zfish   931 HTKERPFICTACNKGFSTKGNLKQHMLTHQMREL------PSQLFEPAN---------------- 973

  Fly   627 KNQPKPPNILKISRNASTQNKPKQ 650
            |....|||.|..|  ..|...||:
Zfish   974 KILVLPPNHLLPS--VETNIPPKR 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	13/80 (16%)
		FYDLN_acid	<191..268	CDD:302856	24/212 (11%)
		C2H2 Zn finger	330..351	CDD:275368	2/20 (10%)
		C2H2 Zn finger	360..378	CDD:275368	5/19 (26%)
		LIM	361..>400	CDD:295319	11/38 (29%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		zf-C2H2_8	389..465	CDD:292531	19/99 (19%)
		C2H2 Zn finger	417..438	CDD:275368	4/23 (17%)
		C2H2 Zn finger	448..465	CDD:275368	6/36 (17%)
		C2H2 Zn finger	477..498	CDD:275368	3/43 (7%)
		C2H2 Zn finger	511..532	CDD:275368	5/54 (9%)
		C2H2 Zn finger	541..562	CDD:275368	8/20 (40%)
		C2H2 Zn finger	570..590	CDD:275368	8/19 (42%)
		C2H2 Zn finger	598..619	CDD:275368	4/20 (20%)
sall1b	XP_005163246.1	C2H2 Zn finger	412..432	CDD:275368	2/19 (11%)
		zf-H2C2_2	424..449	CDD:290200	2/24 (8%)
		C2H2 Zn finger	440..460	CDD:275368	0/19 (0%)
		COG5048	645..1071	CDD:227381	82/381 (22%)
		C2H2 Zn finger	652..672	CDD:275368	5/19 (26%)
		zf-H2C2_2	664..689	CDD:290200	9/24 (38%)
		C2H2 Zn finger	680..700	CDD:275368	6/19 (32%)
		C2H2 Zn finger	712..732	CDD:275368	4/19 (21%)
		C2H2 Zn finger	911..931	CDD:275368	8/20 (40%)
		zf-H2C2_2	923..948	CDD:290200	13/25 (52%)
		C2H2 Zn finger	939..959	CDD:275368	8/19 (42%)
		zf-C2H2	1036..1058	CDD:278523
		C2H2 Zn finger	1038..1058	CDD:275368
		zf-H2C2_2	1050..1075	CDD:290200
		C2H2 Zn finger	1066..1086	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910