DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and znf1010

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_009289662.1	Gene:	znf1010 / 100148686	ZFINID:	ZDB-GENE-131120-161	Length:	327	Species:	Danio rerio

Alignment Length:	360	Identity:	99/360 - (27%)
Similarity:	141/360 - (39%)	Gaps:	59/360 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   312 QQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQ--------RHHRLTHQVDPGYMMC--CGRKFT 366
            ::|..|:.|.:.||          :.|...|.|        .....|.:......:|  ||..||
Zfish     5 KEETEDIKIEETFT----------VKHEDAEQQTDLIVPKEEAEESTSEEKEKPHICSECGSSFT 59

  Fly   367 QRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAID 431
            .:..|..|..:|.....|.|..|.|.|....:...|.:.|..   :..|:|..|.|:|:::..:.
Zfish    60 SKLSLYLHSRIHTGEKLFTCQDCGKCFSQQGNFMYHVKTHTG---EKPFTCQQCGKSFITEGNLK 121

  Fly   432 YHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQEL 496
            .| :..|.  .|..|||.||.|.|........|| .:|..|....|.:|||...|...||.|...
Zfish   122 TH-MKTHA--GEKPFTCKECGKSFSQHGHFVYHM-RIHTGEKPFACQQCGKSFSTNGHLKVHMRF 182

  Fly   497 MHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHICAKVSPNARALRRHIY 559
            ...:||      ..||.||........||.|| ::|   .||  :.|..|.|..|..|:|..| .
Zfish   183 HTGEKP------FSCQQCGKSFTENASLKAHM-NVH---TGEKPYSCTQCGKSFPYKRSLYSH-Q 236

  Fly   560 HNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYE 624
            ..|..|:.:.|:.|||:|....:|..|...||||.||.|..|.::.....|:..| ..:|
Zfish   237 ALHMEEKPYSCSQCEKSFINQGDLNRHLKVHTGENLYICSLCGVSVTTKRNLECH-MNVH----- 295

  Fly   625 ADKNQPKPPNILK----------ISRNASTQNKPK 649
            .||   ||.:.|:          ::|:..|.:.|:
Zfish   296 TDK---KPFSCLQCGKSFRHSGSLTRHNKTHSSPQ 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856
		C2H2 Zn finger	330..351	CDD:275368	3/28 (11%)
		C2H2 Zn finger	360..378	CDD:275368	7/19 (37%)
		LIM	361..>400	CDD:295319	12/38 (32%)
		C2H2 Zn finger	386..406	CDD:275368	5/19 (26%)
		zf-C2H2_8	389..465	CDD:292531	20/75 (27%)
		C2H2 Zn finger	417..438	CDD:275368	5/20 (25%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	8/20 (40%)
		C2H2 Zn finger	511..532	CDD:275368	8/20 (40%)
		C2H2 Zn finger	541..562	CDD:275368	7/20 (35%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	4/20 (20%)
znf1010	XP_009289662.1	C2H2 Zn finger	51..71	CDD:275368	7/19 (37%)
		C2H2 Zn finger	79..99	CDD:275368	5/19 (26%)
		zf-H2C2_2	91..116	CDD:290200	7/27 (26%)
		C2H2 Zn finger	107..127	CDD:275368	5/20 (25%)
		COG5048	<119..311	CDD:227381	67/215 (31%)
		zf-H2C2_2	119..144	CDD:290200	10/27 (37%)
		C2H2 Zn finger	135..155	CDD:275368	7/20 (35%)
		zf-H2C2_2	147..172	CDD:290200	8/25 (32%)
		C2H2 Zn finger	163..183	CDD:275368	8/19 (42%)
		zf-H2C2_2	175..199	CDD:290200	9/29 (31%)
		C2H2 Zn finger	191..211	CDD:275368	8/20 (40%)
		zf-H2C2_2	203..226	CDD:290200	10/26 (38%)
		C2H2 Zn finger	219..239	CDD:275368	7/20 (35%)
		DUF4764	<243..>269	CDD:292583	8/25 (32%)
		C2H2 Zn finger	247..267	CDD:275368	7/19 (37%)
		C2H2 Zn finger	275..295	CDD:275368	4/20 (20%)
		C2H2 Zn finger	303..323	CDD:275368	2/19 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910