DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and si:dkey-77f5.4

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_009289663.1	Gene:	si:dkey-77f5.4 / 100147955	ZFINID:	ZDB-GENE-131121-70	Length:	456	Species:	Danio rerio

Alignment Length:	420	Identity:	104/420 - (24%)
Similarity:	158/420 - (37%)	Gaps:	99/420 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 IQLDLKAEELDE------FVDEETDPD--FSCLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFA 275
            |::....||::|      |..|..||:  ...::|.::...       ||..:|..::..
Zfish    32 IKMAFIKEEIEEVQIGGTFTVEHEDPEEQTGLIMPKEDRMR-------FDQRADLRVNTS----- 84

  Fly   276 VLPKRTVVRPKKY----------KKR---------------TKPAEPKVRMSRELLEQRKKQQEE 315
                 ...|.|.|          :||               |.|...|..:.:..|....:...:
Zfish    85 -----IYARKKPYTCTQCGKVFVQKRSLNGHIGIHTGERPYTCPQCGKGFLYKNSLSIHTRNHSK 144

  Fly   316 YDVIIAKFFTSVLPCAIC--------NLLVH--NFTEMQRHHRLTHQVDPGYMMCCGRKFTQRKV 370
                 .|.||    |..|        ||.:|  :.|| ::.:...|         ||:.|.::..
Zfish   145 -----DKLFT----CGQCGKGYSIKGNLDIHMRSHTE-EKPYTCPH---------CGKSFVRKNT 190

  Fly   371 LAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKL 435
            |..||.:|.....|.|..|||||.....|:.|.::|::..   .:||..|.::|..|.::|.|
Zfish   191 LHAHVRIHTGEKLFACPQCEKSFSLQGQLKIHMRIHLETK---PYSCSQCGRSFYDKKSLDVH-- 250

  Fly   436 NKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSD 500
             ..:...|...||.:|.|.|:.:..|:.| |..|..:..:.|.:||:....|..||.|......:
Zfish   251 -TRIHTGEKPHTCPQCGKSFVHKHSLRIH-SRFHSGQRLLSCQECGRCFSIKANLKAHMRTHTGE 313

  Fly   501 KPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGEHR--CHICAKVSPNARALRRHIYHNHE 563
            |      |..|..||......:.|..||: ||   .||..  |..|.|.......|..|: ..|.
Zfish   314 K------LVTCGQCGKSFANQSYLTTHMR-IH---TGERPFVCKECGKGFHKRGNLTAHM-RTHT 367

  Fly   564 CERKFKCTMCEKAFKRPQELKEHTSTHTGE 593
            .|:.:.|.:||:.|:..|.||.|.|.||.|
Zfish   368 GEKPYSCKICEETFRSTQTLKGHMSVHTAE 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	12/56 (21%)
		C2H2 Zn finger	330..351	CDD:275368	7/30 (23%)
		C2H2 Zn finger	360..378	CDD:275368	6/17 (35%)
		LIM	361..>400	CDD:295319	14/38 (37%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	22/75 (29%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	9/19 (47%)
		C2H2 Zn finger	598..619	CDD:275368
si:dkey-77f5.4	XP_009289663.1	COG5048	82..441	CDD:227381	92/363 (25%)
		C2H2 Zn finger	94..114	CDD:275368	2/19 (11%)
		zf-H2C2_2	106..131	CDD:290200	3/24 (13%)
		C2H2 Zn finger	122..142	CDD:275368	3/19 (16%)
		C2H2 Zn finger	150..170	CDD:275368	5/19 (26%)
		zf-H2C2_2	162..187	CDD:290200	9/34 (26%)
		CpXC	177..>222	CDD:291051	16/53 (30%)
		C2H2 Zn finger	178..198	CDD:275368	7/28 (25%)
		C2H2 Zn finger	206..226	CDD:275368	8/19 (42%)
		SIR2	<221..>273	CDD:294129	15/57 (26%)
		C2H2 Zn finger	234..254	CDD:275368	6/22 (27%)
		zf-H2C2_2	246..271	CDD:290200	8/27 (30%)
		C2H2 Zn finger	262..282	CDD:275368	7/20 (35%)
		C2H2 Zn finger	290..310	CDD:275368	7/19 (37%)
		zf-H2C2_2	302..327	CDD:290200	8/30 (27%)
		C2H2 Zn finger	318..338	CDD:275368	6/20 (30%)
		zf-H2C2_2	330..354	CDD:290200	10/27 (37%)
		C2H2 Zn finger	346..366	CDD:275368	5/20 (25%)
		zf-H2C2_2	358..383	CDD:290200	8/25 (32%)
		C2H2 Zn finger	374..394	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910