DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZNF730

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_016881603.1	Gene:	ZNF730 / 100129543	HGNCID:	32470	Length:	514	Species:	Homo sapiens

Alignment Length:	354	Identity:	90/354 - (25%)
Similarity:	142/354 - (40%)	Gaps:	54/354 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 EQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVDPGYMMC--CGRKFTQRK 369
            :..||....::..:....:.:..|.....:.|.|:...| |::.|.....: .|  ||:.|....
Human   135 KMHKKGYNRHNQCLTTSHSKIFQCDKYVKVFHKFSNSNR-HKIRHTSKKPF-KCKECGKLFCILS 197

  Fly   370 VLAEHVLVH--------------WNPDH-------------FKCSVCEKSFQNSRHLESHQQVHM 407
            .||:|..:|              :|...             :||..|.|:|....|..:|:::|.
Human   198 HLAQHKKIHTGEKSYKCEEYGKAFNESSNCTTHKRITEKKPYKCKECGKAFNWFSHFTTHKRIHT 262

  Fly   408 DPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPE 472
            .   :..:.|:.|.|.|...|.:..|   |.:...|..:.|.||.|.|.....|..| ..:|..|
Human   263 G---EKPYQCEKCGKFFNQSTNLTTH---KRIHTGEKPYKCEECGKAFNQSSNLTEH-KKIHTKE 320

  Fly   473 STIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAG 537
            ....|:||||..:....|.||:.:.:.:||      .:|:.||......:.|.:| |..|  :.|
Human   321 QPYKCEKCGKAFKWSSTLTKHKRIHNGEKP------YKCEECGKAFNRSSTLNRH-KITH--TGG 376

  Fly   538 E-HRCHICAKVSPNARALRRH-IYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPN 600
            : ::...|.|....:..|..| |.|.  .|:.:||..|.|||.|...|..|...||||..|.|..
Human   377 KPYKYKECGKAFNQSSTLTIHKIIHT--VEKFYKCEECGKAFSRISHLTTHKRIHTGEKPYKCEE 439

  Fly   601 CPMTFFCSANMYKHRQRLHRAQ--YEADK 627
            |...|..|:.:..|: |:|..:  ||.::
Human   440 CGRAFNQSSTLTTHK-RIHTGEKPYECEE 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856
		C2H2 Zn finger	330..351	CDD:275368	5/20 (25%)
		C2H2 Zn finger	360..378	CDD:275368	7/19 (37%)
		LIM	361..>400	CDD:295319	14/65 (22%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		zf-C2H2_8	389..465	CDD:292531	20/75 (27%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	8/20 (40%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	6/21 (29%)
		C2H2 Zn finger	570..590	CDD:275368	8/19 (42%)
		C2H2 Zn finger	598..619	CDD:275368	6/20 (30%)
ZNF730	XP_016881603.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910