DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and zgc:171220

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001103300.1	Gene:	zgc:171220 / 100126101	ZFINID:	ZDB-GENE-071004-11	Length:	517	Species:	Danio rerio

Alignment Length:	515	Identity:	131/515 - (25%)
Similarity:	196/515 - (38%)	Gaps:	127/515 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 LKAEELDEFVDE-ETDPDFSCLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRT----- 281
            :|.||.:|.:|: |.:.|      ..|...:..|..|.:.....|.:..||:..:..|.:
Zfish    10 IKDEETEELIDQTEVNED------KQNLFNNPEGFSGENPQIKTEPNAKKQDRTIGAKGSFTCSE 68

  Fly   282 ---VVRPKKYKKRTKPAEPKVRMSRELLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEM 343
               |.|.:.:.||                         ..::.....::|.|:.|.....|..::
Zfish    69 CGKVFRIESWLKR-------------------------HTLMVHNGETLLTCSPCGKSFINEAKL 108

  Fly   344 QRHHRLTHQVDPGYMMC--CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVH 406
            .:|.: :|..:..: .|  ||:.|.....|..||.:|.....|.||||.|||:...:|..||:|:
Zfish   109 DKHLK-SHTRNRSF-TCTECGKIFKSEDKLNNHVRIHDKERPFSCSVCGKSFKTEHNLSQHQRVY 171

  Fly   407 MDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFL----------TERKL 461
            .|  || ..|||.|.|||||::.:   ||:..|...|..:.||.|.|.||          ...::
Zfish   172 CD--VK-PLSCDQCHKTFLSRSLL---KLHLVVHSGERPYVCSLCGKSFLYLNRLNAHERNHAEV 230

  Fly   462 KNHMSSM-----------------HDPESTIICDKCGKQMRTKIILKKHQEL---------MHSD 500
            |.|:.|:                 |....:.:|..|||...||..|||||.:         .|..
Zfish   231 KPHVCSLRGKSFLYMNRLKEHELIHSGVRSHVCPHCGKSFSTKRNLKKHQSVHVEVNPFSCTHCG 295

  Fly   501 KP-RPEPELQ------------QCQIC----------GAWLKGMTGLKQH--------------M 528
            |. |.:..:|            .|..|          ...||...|||.|              :
Zfish   296 KTFRNKRSVQNHLIAHAGVKSFSCDQCDKSFIRASYLNRHLKVHAGLKPHVCSTCGRSFSILQCL 360

  Fly   529 KSIHVESAGE--HRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHT 591
            |...:...||  |.|..|.|....:..||:| ...|..|:.:.|..|.|:|:..:.||.|..:|:
Zfish   361 KRHQLVHTGERPHSCSDCGKSFRTSNYLRKH-QRIHTGEKPYSCAQCGKSFRCTKNLKLHQRSHS 424

  Fly   592 GEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYEADKNQP-KPPNILKISRNASTQNKPKQ 650
            ||..::|..|..||.|.:|:.||.:.....:..:|..|. :....||..:...|..||.|
Zfish   425 GEKPFSCDQCHKTFACPSNLSKHLKAHAAGRVCSDCGQSFRTSAELKTHQRIHTGEKPYQ 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	11/45 (24%)
		C2H2 Zn finger	330..351	CDD:275368	4/20 (20%)
		C2H2 Zn finger	360..378	CDD:275368	7/19 (37%)
		LIM	361..>400	CDD:295319	15/38 (39%)
		C2H2 Zn finger	386..406	CDD:275368	10/19 (53%)
		zf-C2H2_8	389..465	CDD:292531	31/85 (36%)
		C2H2 Zn finger	417..438	CDD:275368	10/20 (50%)
		C2H2 Zn finger	448..465	CDD:275368	7/26 (27%)
		C2H2 Zn finger	477..498	CDD:275368	11/29 (38%)
		C2H2 Zn finger	511..532	CDD:275368	9/44 (20%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	8/20 (40%)
zgc:171220	NP_001103300.1	C2H2 Zn finger	66..87	CDD:275368	4/45 (9%)
		C2H2 Zn finger	95..115	CDD:275368	4/20 (20%)
		COG5048	118..489	CDD:227381	107/375 (29%)
		C2H2 Zn finger	123..143	CDD:275368	7/19 (37%)
		C2H2 Zn finger	151..170	CDD:275368	10/18 (56%)
		C2H2 Zn finger	179..199	CDD:275368	10/22 (45%)
		C2H2 Zn finger	207..227	CDD:275368	6/19 (32%)
		C2H2 Zn finger	235..255	CDD:275368	1/19 (5%)
		zf-C2H2	261..283	CDD:278523	11/21 (52%)
		C2H2 Zn finger	263..283	CDD:275368	11/19 (58%)
		C2H2 Zn finger	291..311	CDD:275368	4/19 (21%)
		C2H2 Zn finger	319..339	CDD:275368	4/19 (21%)
		C2H2 Zn finger	347..367	CDD:275368	1/19 (5%)
		zf-H2C2_2	360..384	CDD:290200	7/23 (30%)
		C2H2 Zn finger	375..395	CDD:275368	6/20 (30%)
		zf-H2C2_2	387..412	CDD:290200	9/25 (36%)
		C2H2 Zn finger	403..423	CDD:275368	7/19 (37%)
		zf-H2C2_2	415..440	CDD:290200	10/24 (42%)
		C2H2 Zn finger	431..451	CDD:275368	8/19 (42%)
		C2H2 Zn finger	485..505	CDD:275368	131/515 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910