DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and gli3

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_004915407.1	Gene:	gli3 / 100101789	XenbaseID:	XB-GENE-484855	Length:	1566	Species:	Xenopus tropicalis

Alignment Length:	219	Identity:	49/219 - (22%)
Similarity:	87/219 - (39%)	Gaps:	58/219 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   436 NKHVPKSEFKFTC--SECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMH 498
            :|..|:..::..|  ..|:::|.|:.:|.:|:::.|                           :|
Frog   474 SKQEPEVVYETNCHWEGCSREFDTQEQLVHHINNDH---------------------------IH 511

  Fly   499 SDKPRPEPELQQCQICGAWLKGMTGLK----QHMKSIHV-ESAGE--HRCHI--CAKVSPNARAL 554
            .:|..        .:| .||......|    |:|..:|: ...||  |:|..  |:|.......|
Frog   512 GEKKE--------FVC-RWLDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENL 567

  Fly   555 RRHIYHNHECERKFKCTM--CEKAFKRPQELKEHTS-THTGEVLYTC--PNCPMTFFCSANMYKH 614
            :.|: .:|..|:.:.|..  |.|||....:..:|.: ||:.|..|.|  |.|...:...:::.||
Frog   568 KTHL-RSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKH 631

  Fly   615 RQRLHRAQYEADKNQ-----PKPP 633
            .:.:|..:....|.|     |:||
Frog   632 VKTVHGPEAHVTKKQRGDIHPRPP 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856
		C2H2 Zn finger	330..351	CDD:275368
		C2H2 Zn finger	360..378	CDD:275368
		LIM	361..>400	CDD:295319
		C2H2 Zn finger	386..406	CDD:275368
		zf-C2H2_8	389..465	CDD:292531	7/30 (23%)
		C2H2 Zn finger	417..438	CDD:275368	0/1 (0%)
		C2H2 Zn finger	448..465	CDD:275368	5/18 (28%)
		C2H2 Zn finger	477..498	CDD:275368	0/20 (0%)
		C2H2 Zn finger	511..532	CDD:275368	6/24 (25%)
		C2H2 Zn finger	541..562	CDD:275368	5/22 (23%)
		C2H2 Zn finger	570..590	CDD:275368	6/22 (27%)
		C2H2 Zn finger	598..619	CDD:275368	5/22 (23%)
gli3	XP_004915407.1	PHA03247	<54..441	CDD:223021
		SFP1	<546..636	CDD:227516	25/90 (28%)
		C2H2 Zn finger	552..574	CDD:275368	5/22 (23%)
		C2H2 Zn finger	582..605	CDD:275368	6/22 (27%)
		C2H2 Zn finger	613..634	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910