DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and ZSCAN30

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001106205.1	Gene:	ZSCAN30 / 100101467	HGNCID:	33517	Length:	494	Species:	Homo sapiens

Alignment Length:	538	Identity:	109/538 - (20%)
Similarity:	175/538 - (32%)	Gaps:	160/538 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 LTQETTSFPEIIKLATQEEEGVTEPQELGGRNFFYPEIKIEEHE----LDTLPRIEILERSANTQ 152
            |..|..|..:|::|...|:.....|:||        :..:.||.    .:.:..:|.||:.....
Human    77 LRPEVHSKEQILELLMLEQFLAILPEEL--------QAWLREHRPENGEEAVTMLEELEKELEEP 133

  Fly   153 ENQDQLEGAARRLRK-----RLKAEDGSSVDKDKDEDGVEETAEPAPPKKRRGR----------- 201
            ..||...|.....::     .||:...:|..:..:.....||.|....::|.||
Human   134 RQQDTTHGQEMFWQEMTSTGALKSLSLNSPVQPLENQCKTETQESQAFQERDGRMVAGKVLMAKQ 198

  Fly   202 ---PRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDS 263
               ...:.||:..|.|        |..|...:.:.||      .|...|||.:..|.:.|   :.
Human   199 EIVECVASAAMISPGK--------LPGETHSQRIAEE------ALGGLDNSKKQKGNAAG---NK 246

  Fly   264 DFELDNGKQEFAVLPKRTVVRPKKYKKRTKPAEPKVRMSRE---------------LLEQRKKQQ 313
            ..:|.:..:.|::         ..:.:|. |.|..|..|.|               .::.|:|..
Human   247 ISQLPSQDRHFSL---------ATFNRRI-PTEHSVLESHESEGSFSMNSNDITQQSVDTREKLY 301

  Fly   314 EEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVDPGYMMCCGRKFTQRKVLAEHVLVH 378
            |.:|                                           ||:.|.|...|..|..:|
Human   302 ECFD-------------------------------------------CGKAFCQSSKLIRHQRIH 323

  Fly   379 WNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSE 443
            .....:.|..|.|:|..|..|..||::|   :.:..:.|..|.|.|...:.:..|   :.:...|
Human   324 TGERPYACKECGKAFSLSSDLVRHQRIH---SGEKPYECCECGKAFRGSSELIRH---RRIHTGE 382

  Fly   444 FKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPEL 508
            ..:.|.||.|.|.....|..| ..:|..:.:..|..|||......||.:||.:...:||
Human   383 KPYECGECGKAFSRSSALIQH-KKIHTGDKSYECIACGKAFGRSSILIEHQRIHTGEKP------ 440

  Fly   509 QQCQICGAWLKGMTGLKQHMKSIHVESAGEHRCHICAKVSPNARALRRHIYHNHECERKFKCTMC 573
            .:|..||......:.|.||.:.                               |..|:.::|:.|
Human   441 YECNECGKSFNQSSALTQHQRI-------------------------------HTGEKPYECSEC 474

  Fly   574 EKAFKRPQELKEHTSTHT 591
            .|.|:....|.:|..|||
Human   475 RKTFRHRSGLMQHQRTHT 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	18/90 (20%)
		C2H2 Zn finger	330..351	CDD:275368	0/20 (0%)
		C2H2 Zn finger	360..378	CDD:275368	6/17 (35%)
		LIM	361..>400	CDD:295319	12/38 (32%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	20/75 (27%)
		C2H2 Zn finger	417..438	CDD:275368	5/20 (25%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	8/20 (40%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	0/20 (0%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368
ZSCAN30	NP_001106205.1	SCAN	44..154	CDD:128708	17/84 (20%)
		SCAN	44..122	CDD:280241	11/52 (21%)
		COG5048	281..>360	CDD:227381	20/124 (16%)
		zf-C2H2	301..323	CDD:278523	8/64 (13%)
		C2H2 Zn finger	303..323	CDD:275368	7/62 (11%)
		zf-H2C2_2	316..339	CDD:290200	6/22 (27%)
		COG5048	<328..479	CDD:227381	44/194 (23%)
		C2H2 Zn finger	331..351	CDD:275368	8/19 (42%)
		zf-H2C2_2	343..366	CDD:290200	7/25 (28%)
		C2H2 Zn finger	359..379	CDD:275368	5/22 (23%)
		zf-H2C2_2	371..396	CDD:290200	7/27 (26%)
		C2H2 Zn finger	387..407	CDD:275368	7/20 (35%)
		zf-H2C2_2	399..424	CDD:290200	7/25 (28%)
		C2H2 Zn finger	415..435	CDD:275368	8/19 (42%)
		zf-H2C2_2	428..452	CDD:290200	8/29 (28%)
		C2H2 Zn finger	443..463	CDD:275368	6/50 (12%)
		zf-H2C2_2	455..480	CDD:290200	9/55 (16%)
		C2H2 Zn finger	471..491	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910