DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and zfp64

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001373446.1	Gene:	zfp64 / 100003733	ZFINID:	ZDB-GENE-031118-80	Length:	642	Species:	Danio rerio

Alignment Length:	448	Identity:	99/448 - (22%)
Similarity:	165/448 - (36%)	Gaps:	95/448 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 CLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRPKKY-KKRTKPAEPKVR----- 300
            |.:||.:.|..:.|:    |:|       .|......|:|:.:.:|. .|:.|||..:.|
Zfish    44 CQIPSTHISVRNAGA----SES-------LQTCVSKVKKTLTKAQKNPSKKLKPALTQKRHICTF 97

  Fly   301 -------------MSRELLEQRKKQQEEYDVIIAKF------------FTSVLP--CAICNLLVH 338
                         |.|.:|....::..|.::...:|            .|...|  |..|.....
Zfish    98 SGCTFKTQYGQKDMERHILTHTGERPFECELCHKRFSRRDKLNLHSRLHTGEKPHKCKYCTYAAA 162

  Fly   339 NFTEMQRHHRLTHQVDPGYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQ 403
            :.:.:::|.|:.:...|.....|.........|..|:..|.....|:|:.|:..|:.:..|:.|.
Zfish   163 DSSSLKKHLRIHYDERPFKCQICPYASRNSSQLTVHLRSHTGDAPFQCNQCDAKFKINSDLKRHS 227

  Fly   404 QVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSM 468
            :||   :.:..:.||||......|..:..|...||  .:...|.||:|:.:..|:..|::| |..
Zfish   228 RVH---SGEKPYKCDLCDYRCAMKANLKSHVHLKH--SASDSFHCSKCDFQCSTKAALRHH-SRQ 286

  Fly   469 HDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHV 533
            |.|...:.|.:|.....:|..||.| |.:|||: ||    .:|.:|....|..:.|..|.:..|.
Zfish   287 HQPAQPLQCSECSYSCSSKGALKIH-ERVHSDE-RP----FKCDLCSFASKQRSNLLIHTRKCHA 345

  Fly   534 ESAGEHRCHICAKVSPNARALRRHIYHNH----ECERKFKCTMCEKAFKRPQELKEHTSTHTGEV 594
            :.  ..|.....::|.|...|.:.|...:    |..|.::|.:||.:|.|...|:.|...|....
Zfish   346 DK--PDRLSKSGRISGNGEDLTKPISSRYRAKLEATRAYRCDLCEASFVREDSLRSHKRQHNNIT 408

  Fly   595 LYTCPNCPMTFFCSANMYKHRQRLHRAQYEADKNQPKPPNILKISRNASTQNKPKQEI 652
                                :|:.|....:....||             .||.|:..|
Zfish   409 --------------------QQQSHNQTSQTSTKQP-------------VQNIPEASI 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	7/25 (28%)
		C2H2 Zn finger	330..351	CDD:275368	4/20 (20%)
		C2H2 Zn finger	360..378	CDD:275368	3/17 (18%)
		LIM	361..>400	CDD:295319	8/38 (21%)
		C2H2 Zn finger	386..406	CDD:275368	5/19 (26%)
		zf-C2H2_8	389..465	CDD:292531	20/75 (27%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	4/20 (20%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	1/20 (5%)
zfp64	NP_001373446.1	C2H2 Zn finger	95..118	CDD:275368	3/22 (14%)
		zf-H2C2_2	110..135	CDD:404364	5/24 (21%)
		C2H2 Zn finger	126..146	CDD:275368	1/19 (5%)
		zf-H2C2_2	139..162	CDD:404364	4/22 (18%)
		C2H2 Zn finger	154..174	CDD:275368	4/19 (21%)
		SFP1	<176..260	CDD:227516	21/88 (24%)
		C2H2 Zn finger	182..202	CDD:275368	3/19 (16%)
		C2H2 Zn finger	210..230	CDD:275368	5/19 (26%)
		zf-H2C2_2	222..246	CDD:404364	8/26 (31%)
		C2H2 Zn finger	238..257	CDD:275368	6/18 (33%)
		C2H2 Zn finger	323..341	CDD:275368	5/17 (29%)
		C2H2 Zn finger	384..404	CDD:275368	7/19 (37%)
		SP1-4_N	<408..>605	CDD:425404	8/59 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577397
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.030