Protein Alignment CG8060 and HERC1

DIOPT Version :10

• Sequence 1: NP_611117.2
• Gene: CG8060 / 36824
• FlyBaseID: FBgn0034113
• Length: 1189
• Species: Drosophila melanogaster
• Sequence 2: XP_047289166.1
• Gene: HERC1 / 8925
• HGNCID: 4867
• Length: 4909
• Species: Homo sapiens
• Alignment Length: 1469
• Identity: 271/1469 - (18%)
• Similarity: 452/1469 - (30%)
• Gaps: 550/1469 - (37%)

  Fly    54 DDLGRS-------AVHMSASTARYEILEWLLNHGAYINGQDYESGSSPLHRALYYG--------- 102
            |.|||.       .:.....:.|| :|||:          :...|:|.:...:..|
Human   240 DTLGRRLASELLLGLAAQRGSLRY-LLEWI----------EMALGASAVVHTMEKGKLLSSQEGM 293

  Fly   103 -SIDCAVLLL--------------------RYGASLELLDEDTRCPLQAICRKCDD--------D 138
             |.||.:.:|                    |....|..|.|...|..:.:||...|        |
Human   294 ISFDCFMTILMQMRRSLGSSADRSQWREPTRTSDGLCSLYEAALCLFEEVCRMASDYSRTCASPD 358

  Fly   139 DLAT------DSQNDVLVWGSNKNYNLGIGNEQNTNTPQAVDFFRKSNLWLEQVALGAYHSLFCD 197
            .:.|      ....:|.|||||.::.|..|.::....|:....|..:    :.:..|.|.:....
Human   359 SIQTGDAPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDA----QTIEAGQYCTFVIS 419

  Fly   198 KKGHLYAVGHGKGGRLGIGLENSLPAPKRV---------KVSSKLSGDSIQCISVSRQHSLVLTH 253
            ..|.:.|.|.|..||||:|..|:....|::         ||||....|.         |:|..|.
Human   420 TDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDG---------HTLAFTT 475

  Fly   254 QSLVFACGLNTDHQLGVRDAAEQLTQFKEVVALRDKGASDLVRVIAC----DQHSIAY---GSRC 311
            :..||:.|.....:||..:::.|  ::.:::....:|     :|:.|    .:||.|.   |.
Human   476 EGEVFSWGDGDYGKLGHGNSSTQ--KYPKLIQGPLQG-----KVVVCVSAGYRHSAAVTEDGE-- 531

  Fly   312 VYVWGANQGQFGI--NSNTPSITVPTLIKLPAKTTIRFVEANNAATVIYNEEKIITLC------- 367
            :|.||  :|.||.  :.::.|..:|||:|          :.:|...|.......|.|.
Human   532 LYTWG--EGDFGRLGHGDSNSRNIPTLVK----------DISNVGEVSCGSSHTIALSKDGRTVW 584

  Fly   368 -----------YADKTRYIKTPNYEDLKSISVMGGNLKNSTKGSAAALKLLMLTETNVVYLWYEN 421
                       :.|..|..|....|.|:.:.:        .|..|.:...|.||.|..||.|  .
Human   585 SFGGGDNGKLGHGDTNRVYKPKVIEALQGMFI--------RKVCAGSQSSLALTSTGQVYAW--G 639

  Fly   422 TQQFYRCNFS-----------PIRLHQIKKILYKCNQVMVLSEDGCVY------RGKCNQ----- 464
            ......|..|           .:...:|..:....:..:.||.|..||      .|:|.|
Human   640 CGACLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTG 704

  Fly   465 -IALPSS-------ALQEKSRGSLDN--WQDNDQNKTEISREHVIRIELQRVPNIDRATYIFCDE 519
             |..|..       |:|:.|.|:..:  |....:::..::......::|:.
Human   705 PITKPKKVSGLDGIAIQQISAGTSHSLAWTALPRDRQVVAWHRPYCVDLEE-------------- 755

  Fly   520 GFSSFAVLQESHTKYFRK-----PSLP----RREHSFKKL------------------------- 550
              |:|:.|:....:|..|     |.||    |..|||.||
Human   756 --STFSHLRSFLERYCDKINSEIPPLPFPSSREHHSFLKLCLKLLSNHLALALAGGVATSILGRQ 818

  Fly   551 ----------LHETSDCDAVHDVVFHVDGEKFAAHKFIIYSRAPGLR---DLIRCYLDK--DIYL 600
                      |.:::..|.:.:||.    |..:....::   .|.||   :|:...|.:  |.:.
Human   819 AGPLRNLLFRLMDSTVPDEIQEVVI----ETLSVGATML---LPPLRERMELLHSLLPQGPDRWE 876

  Fly   601 NFDHLTGKMFELIL------NHIYS--SYWPTEDDIDCIQQSLGPANPQQR---TRTC------- 647
            :.........::||      .|:.|  .|....|..|......|..|...:   |::|
Human   877 SLSKGQRMQLDIILTSLQDHTHVASLLGYSSPSDAADLSSVCTGYGNLSDQPYGTQSCHPDTHLA 941

  Fly   648 --------------------------EMFL-----------PHLEKFQLVELTKYVQSY------ 669
                                      :.||           .||.:. |..|.|.:.::
Human   942 EILMKTLLRNLGFYTDQAFGELEKNSDKFLLGTSSSENSQPAHLHEL-LCSLQKQLLAFCHINNI 1005

  Fly   670 ---------VRDH-QFPLPNARKLFNRLYR--SDHP-------ELYDVRIVCKDGKVLGAHKCML 715
                     :..| |..||:|..:::|...  .:.|       :|.||..|...|.:|    |.:
Human  1006 SENSSSVALLHKHLQLLLPHATDIYSRSANLLKESPWNGSVGEKLRDVIYVSAAGSML----CQI 1066

  Fly   716 VARLEYFEMMFMHLWAERSSVTMEGVPAEYMEPVLDYLYSLDNEAFCKQGYLETFLYNMITICDQ 780
            |                 :|:.:  :|.....|:|.||..|.....|        |..::...|.
Human  1067 V-----------------NSLLL--LPVSVARPLLSYLLDLLPPLDC--------LNRLLPAADL 1104

  Fly   781 YFIESLQ------------------NVCESLI----LDK---ISIRKC-GEML----------EF 809
            ...:.||                  ...:|.:    |::   :.|.:| |.||          :.
Human  1105 LEDQELQWPLHGGPELIDPAGLPLPQPAQSWVWLVDLERTIALLIGRCLGGMLQGSPVSPEEQDT 1169

  Fly   810 AAMYNCKILQKGC-MDFICQNLSRVLCYRSIEQCDGETLKCL-------NDHYRKMFKRVFDYR- 865
            |......:...|. ||           ...:::|    :.||       |:.     ::.|||:
Human  1170 AYWMKTPLFSDGVEMD-----------TPQLDKC----MSCLLEVALSGNEE-----QKPFDYKL 1214

  Fly   866 --QITPFSE---------------AIEDELLLSFVDGCDVDLNYRMDAESKLKQAAKHKQKDL-- 911
              :|..:.:               :::|..:....|...:.....:|..|:...||..|..:|
Human  1215 RPEIAVYVDLALGCSKEPARSLWISMQDYAVSKDWDSATLSNESLLDTVSRFVLAALLKHTNLLS 1279

  Fly   912 ------RKQDARHQYEQQAISSMMRS---------LSISESTQGTEVPSSPQDSA--RSEDKNWS 959
                  |.|..:|..|.......:||         |..:.|:......|..||||  ..::.:::
Human  1280 QACGESRYQPGKHLSEVYRCVYKVRSRLLACKNLELIQTRSSSRDRWISENQDSADVDPQEHSFT 1344

  Fly   960 RVVDKKDQKRKLAETALKVNNTLKHEDPPTQELVPIERKPLKEQTPPPPSHETEPTTPLSKSYNL 1024
            |.:|::.:..:.||                        :..:|..|.|...|.|....:..:.||
Human  1345 RTIDEEAEMEEQAE------------------------RDREEGHPEPEDEEEEREHEVMTAGNL 1385

  Fly  1025 --------DFSSLTPQSQKLSQKQRKRLSSESKSW-RTNNPPLVEQSSTPVAVPNAWGVTTTPSG 1080
                    .|.......:....:.|.|::|.:.|. |.::||...|....|:       |..|.|
Human  1386 VFVLHVTEIFQCFLSAREVARSRDRDRMNSGAGSGARADDPPPQSQQERRVS-------TDLPEG 1443

  Fly  1081 SFNDSFT-----------------SPT---------TGSSTDPTSFANMMRGHATSSTTPTDQSQ 1119
              .|.:|                 ||.         .|....|::.|:...|..|.|.:.|.:|:
Human  1444 --QDVYTAACNSVIHRCALLILGVSPVIDELQKRREEGQLQQPSTSASEGGGLMTRSESLTAESR 1506

  Fly  1120 SFSRILADEKRQRESYERMRNKSLVHTQIEERAIAELRE 1158
                                   ||||....|.|....|
Human  1507 -----------------------LVHTSPNYRLIKSRSE 1522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8060	NP_611117.2	ANKYR	<51..141	CDD:440430	25/131 (19%)
		ANK repeat	56..87	CDD:293786	8/37 (22%)
		ANK repeat	89..121	CDD:293786	9/61 (15%)
		ATS1	140..>355	CDD:444065	57/238 (24%)
		BTB_POZ	543..643	CDD:453885	25/147 (17%)
		BTB2_POZ_IBtk	691..802	CDD:349611	24/142 (17%)
		BACK_IBtk	798..857	CDD:350575	13/77 (17%)
HERC1	XP_047289166.1	ATS1	374..703	CDD:444065	84/372 (23%)
		RCC1	683..733	CDD:395335	12/49 (24%)
		SPRY_HERC1	2063..2220	CDD:293939
		UBA_HERC1	2784..2827	CDD:270584
		WD40	<3435..3826	CDD:441893
		WD40 repeat	3480..3523	CDD:293791
		WD40 repeat	3537..3572	CDD:293791
		WD40 repeat	3577..3624	CDD:293791
		WD40 repeat	3633..3668	CDD:293791
		WD40 repeat	3677..3713	CDD:293791
		WD40 repeat	3720..3751	CDD:293791
		WD40 repeat	3798..3834	CDD:293791
		ATS1	4047..4383	CDD:444065
		HECTc	4521..4889	CDD:238033