DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8060 and HERC2

DIOPT Version :9

Sequence 1:	NP_611117.2	Gene:	CG8060 / 36824	FlyBaseID:	FBgn0034113	Length:	1189	Species:	Drosophila melanogaster
Sequence 2:	NP_004658.3	Gene:	HERC2 / 8924	HGNCID:	4868	Length:	4834	Species:	Homo sapiens

Alignment Length:	579	Identity:	132/579 - (22%)
Similarity:	225/579 - (38%)	Gaps:	112/579 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 DNQKLASFIFKTCGNFANILDDLGRSAVHMSASTARYEILEWLLNHGAYINGQDYESGSSPLHRA 98
            |:..:.|.:..:.||..|.|.:|  ..::::.|.....:|.....:..||.....:..||
Human  2841 DSSYMPSLVVVSGGNSLNNLIEL--KTININPSDTTVPLLNDCTEYHRYIEIAIKQCRSS----- 2898

  Fly    99 LYYGSIDC----AVLLLRYGASLELL------------DEDTRCPLQAICR-KCDDDDLATDSQN 146
                .|||    .:||.|..|..|.|            :||.:....::.| |....:.|...:.
Human  2899 ----GIDCKIHGLILLGRIRAEEEDLAAVPFLASDNEEEEDEKGNSGSLIRKKAAGLESAATIRT 2959

  Fly   147 DVLVWGSNKNYNLGIGNEQNTNTPQAVDFFRKSNLWLEQVALGAYHSLFC-DKKGHLYAVGHGKG 210
            .|.|||.|....||.........|...:..  |.|.:.||| |...|||. ..:|.:||.|....
Human  2960 KVFVWGLNDKDQLGGLKGSKIKVPSFSETL--SALNVVQVA-GGSKSLFAVTVEGKVYACGEATN 3021

  Fly   211 GRLGIGLEN-SLPAPKRVKVSSKLSGDSIQCISV--SRQHSLVLTHQSLVFACGLNTDHQLGVRD 272
            ||||:|:.: ::|.|:::   :.||...::.::|  ..:|:..||....||:.|...|.:|| ..
Human  3022 GRLGLGISSGTVPIPRQI---TALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLG-HF 3082

  Fly   273 AAEQLTQFKEVVALRDKGASDLVRVIAC-DQHSIAY-GSRCVYVWGANQ-GQFGINSNTPSITVP 334
            :.....:.:.:.||:.|    .:|.||| ..||.|. .|..:|.||..: |:.|...||..:. |
Human  3083 SRMNCDKPRLIEALKTK----RIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLK-P 3142

  Fly   335 TLIKLPAKTTIRFVE--ANNAATVIYNEEKIITLCYADKTRYIKTPNYEDLKSISVMGGNLKNST 397
            .::|:.....:..|.  :.:|.|:...:|.:: ..:.|       .::..|......|.|:..:.
Human  3143 KMVKVLLGHRVIQVACGSRDAQTLALTDEGLV-FSWGD-------GDFGKLGRGGSEGCNIPQNI 3199

  Fly   398 KG---------SAAALKLLMLTETNVVYLWYENTQQFYRCNFSP---IRLHQI------KKILYK 444
            :.         ...|...|.||::.||:.|.:.  .::|.....   :|..|:      |||::
Human  3200 ERLNGQGVCQIECGAQFSLALTKSGVVWTWGKG--DYFRLGHGSDVHVRKPQVVEGLRGKKIVH- 3261

  Fly   445 CNQVMVLSEDGCVYRGKCNQIALPSSALQEKSRGSLDNWQDNDQNK-----TEISREHVI--RIE 502
                        |..|..:.:|:..|       |.:..|.|||..:     |.::|:..:  .:|
Human  3262 ------------VAVGALHCLAVTDS-------GQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLE 3307

  Fly   503 LQRVPNIDRATYIFCDEGFSSFAVLQESHTKYFRKPSL--PRREHSFKKLLHETSDCDA 559
            .|::      |.:.|....|......:..|....:|.|  ..|:......|...||.|:
Human  3308 GQKI------TRVACGSSHSVAWTTVDVATPSVHEPVLFQTARDPLGASYLGVPSDADS 3360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8060	NP_611117.2	ANK	<46..138	CDD:238125	24/108 (22%)
		ANK repeat	56..87	CDD:293786	5/30 (17%)
		Ank_4	57..111	CDD:290365	10/57 (18%)
		ANK repeat	89..121	CDD:293786	11/47 (23%)
		Ank_2	95..>138	CDD:289560	13/59 (22%)
		RCC1	147..195	CDD:278826	15/47 (32%)
		RCC1	199..251	CDD:278826	15/54 (28%)
		BTB	547..>635	CDD:295341	4/13 (31%)
		BTB	684..795	CDD:279045
		BTB	697..798	CDD:197585
		SPOP_C_like	798..>834	CDD:269810
HERC2	NP_004658.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..88
		RCC1 1-1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	415..461
		RCC1 1-2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	462..512
		RCC1 1-3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	513..568
		RCC1	514..566	CDD:278826
		RCC1 1-4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	569..620
		RCC1	569..620	CDD:278826
		RCC1 1-5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	623..674
		RCC1	623..672	CDD:278826
		RCC1 1-6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	675..726
		RCC1	675..724	CDD:278826
		RCC1 1-7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	728..778
		Cyt-b5	1209..1282	CDD:278597
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1555..1575
		MIB_HERC2	1870..1929	CDD:284184
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1933..1958
		UBA_HERC2	2460..2507	CDD:270585
		Cul7	2554..2631	CDD:288381
		ZZ_HERC2	2706..2750	CDD:239084
		APC10-HERC2	2765..2910	CDD:176485	16/79 (20%)
		RCC1 2-1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	2958..3009		17/53 (32%)
		RCC1	2960..3007	CDD:278826	17/49 (35%)
		RCC1 2-2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	3010..3064		16/56 (29%)
		RCC1	3010..3062	CDD:278826	15/54 (28%)
		RCC1 2-3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	3065..3116		16/55 (29%)
		RCC1	3065..3114	CDD:278826	15/53 (28%)
		RCC1	3117..3168	CDD:278826	13/51 (25%)
		RCC1 2-4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	3118..3168		12/50 (24%)
		RCC1 2-5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	3171..3222		8/58 (14%)
		RCC1	3171..3220	CDD:278826	7/56 (13%)
		RCC1	3223..3272	CDD:278826	11/63 (17%)
		RCC1 2-6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	3224..3274		12/64 (19%)
		RCC1 2-7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	3275..3326		13/63 (21%)
		RCC1	3275..3324	CDD:278826	13/61 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3602..3629
		RCC1 3-1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	3951..4002
		RCC1 3-2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	4004..4056
		RCC1_2	4039..4069	CDD:290274
		RCC1	4057..4106	CDD:278826
		RCC1 3-3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	4058..4108
		RCC1 3-4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	4110..4162
		RCC1	4110..4160	CDD:278826
		RCC1	4163..4212	CDD:278826
		RCC1 3-5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	4164..4214
		RCC1	4215..4263	CDD:278826
		RCC1 3-6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	4216..4266
		RCC1	4267..4316	CDD:278826
		RCC1 3-7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	4268..4318
		HECTc	4421..4792	CDD:238033
		HECTc	4464..4790	CDD:214523
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4804..4834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900