DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8060 and SRM1

DIOPT Version :9

Sequence 1:	NP_611117.2	Gene:	CG8060 / 36824	FlyBaseID:	FBgn0034113	Length:	1189	Species:	Drosophila melanogaster
Sequence 2:	NP_011418.1	Gene:	SRM1 / 852782	SGDID:	S000003065	Length:	482	Species:	Saccharomyces cerevisiae

Alignment Length:	389	Identity:	69/389 - (17%)
Similarity:	124/389 - (31%)	Gaps:	134/389 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 DVLVWGSNKNYNLGIG---NEQNTNTPQAVDFFRKSNLWLEQVALGAYHSLFCDKKGHLYAVGHG 208
            |:..||:.....||:|   ..:....|:...|..:....:...|:|..|:|..|::.::::.|..
Yeast    47 DIFCWGTGSMCELGLGPLAKNKEVKRPRLNPFLPRDEAKIISFAVGGMHTLALDEESNVWSWGCN 111

  Fly   209 KGGRLGIGLEN-------------------------SLPA--PKRV--------KVSSKLSGDSI 238
            ..|.||....|                         |.||  |:..        ||....:.|::
Yeast   112 DVGALGRDTSNAKEQLKDMDADDSSDDEDGDLNELESTPAKIPRESFPPLAEGHKVVQLAATDNM 176

  Fly   239 QC-----------------------------------------------ISVSRQHSLVLTHQSL 256
            .|                                               ::..:.|.|.|..:.:
Yeast   177 SCALFSNGEVYAWGTFRCNEGILGFYQDKIKIQKTPWKVPTFSKYNIVQLAPGKDHILFLDEEGM 241

  Fly   257 VFACGLNTDHQLGVRDAAEQLTQFK-EVVALRDKGASDLVRVIACDQHSIAYGSRCVYV-WGANQ 319
            |||.|....:|||    .:.:.:|: :.:..|..|...:..:.:.:.|..|.......| ||.||
Yeast   242 VFAWGNGQQNQLG----RKVMERFRLKTLDPRPFGLRHVKYIASGENHCFALTKDNKLVSWGLNQ 302

  Fly   320 -GQFGINSNTPS---ITVPTLIKLPAKTTIRFVEANNAATVIYNEEKIITLC------------- 367
             ||.|::.:...   :|.|..:.||....||.:.|....::|.:::..:..|
Yeast   303 FGQCGVSEDVEDGALVTKPKRLALPDNVVIRSIAAGEHHSLILSQDGDLYSCGRLDMFEVGIPKD 367

  Fly   368 ------YAD---KTRYIKTP----NYEDLKSISVMGGNLKNSTKGSAAALKLLMLTETNVVYLW 418
                  |.|   |.|.:..|    |....||:             :|.:...:.:.:..:.|.|
Yeast   368 NLPEYTYKDVHGKARAVPLPTKLNNVPKFKSV-------------AAGSHHSVAVAQNGIAYSW 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8060	NP_611117.2	ANK	<46..138	CDD:238125
		ANK repeat	56..87	CDD:293786
		Ank_4	57..111	CDD:290365
		ANK repeat	89..121	CDD:293786
		Ank_2	95..>138	CDD:289560
		RCC1	147..195	CDD:278826	11/50 (22%)
		RCC1	199..251	CDD:278826	15/133 (11%)
		BTB	547..>635	CDD:295341
		BTB	684..795	CDD:279045
		BTB	697..798	CDD:197585
		SPOP_C_like	798..>834	CDD:269810
SRM1	NP_011418.1	ATS1	15..477	CDD:227511	69/389 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900