DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8060 and FMP25

DIOPT Version :9

Sequence 1:	NP_611117.2	Gene:	CG8060 / 36824	FlyBaseID:	FBgn0034113	Length:	1189	Species:	Drosophila melanogaster
Sequence 2:	NP_013178.1	Gene:	FMP25 / 850766	SGDID:	S000004067	Length:	583	Species:	Saccharomyces cerevisiae

Alignment Length:	411	Identity:	83/411 - (20%)
Similarity:	145/411 - (35%)	Gaps:	131/411 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 TKRSIDNQKLASFIFKTCGNFANILDDLGR---------SAVHMSASTARYEIL--------EWL 76
            ||..:.:|.|.|  .|...:|...|:..|.         ..:....|:.|.::|        :|.
Yeast   219 TKTILPDQDLTS--MKYSSHFLYALNKKGEILVIPIRTPDLIASQVSSRRSKLLPWKTKLRYDWK 281

  Fly    77 LNHGAYINGQD-------YESGSSPLHRALYYGSIDCAVLLLRYGASLELLDEDTRCPLQAICRK 134
            |......||::       :::||..|            |||...|              :|.|..
Yeast   282 LQTNQIFNGKEGEKRVVQFDAGSHHL------------VLLSNLG--------------KAYCCA 320

  Fly   135 CDDDD-----------LATDSQNDVLVWGSNKNYNLGIGNEQNTNTPQAVDFFRKSNLWLEQVAL 188
            ..:|.           :.|.||.|... .:|:.:.:.:.|:..   .:..|..||..  ::::|.
Yeast   321 TGNDQKQAQVSKGQFGIPTFSQFDEFP-PNNQLFEIELLNKFK---HEGEDVVRKRE--IKKIAC 379

  Fly   189 GAYHSLFCDKKGHLYAVGHGKGGRLGIGLENSL---PAPKRVKVSSKLSGDSI---QCISVS--- 244
            |:||:|..||.|.:||.|..:.|:|.:.:..:|   ..|:.|..:.|.....:   :|:.:.
Yeast   380 GSYHTLAIDKTGEIYAFGWNRFGQLALPISYNLEYVSFPRSVTHAFKPHFPGMTNWKCVDIHCDD 444

  Fly   245 -------RQHSLVLTHQSLVFACGL------NTDHQLGVRDAAEQLTQFKEVVALRDKGASDLVR 296
                   |:......|....|..||      ||               ||       ....|.::
Yeast   445 ETSFVTIRKPGSTSDHHYFAFGNGLFGELGNNT---------------FK-------NSQCDPIK 487

  Fly   297 VIACDQH--SIAYGSRCVY----------VWGAN-QGQFGINSNT----PSITVPTLIKLPAKTT 344
            :.:.|:.  :.:.||.||:          .||.| .||.||...|    ..:.:|.::| |.:.|
Yeast   488 IKSDDKKLTNWSCGSHCVFTETEQENEVIAWGNNDHGQLGIGKKTMKCAKPMNIPEVLK-PGQDT 551

  Fly   345 IRFVEANNAATVIYNEEKIIT 365
            .......|:...:..|::::|
Yeast   552 TDLDSIYNSKLHLKKEQRVVT 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8060	NP_611117.2	ANK	<46..138	CDD:238125	19/115 (17%)
		ANK repeat	56..87	CDD:293786	8/47 (17%)
		Ank_4	57..111	CDD:290365	13/77 (17%)
		ANK repeat	89..121	CDD:293786	7/31 (23%)
		Ank_2	95..>138	CDD:289560	7/42 (17%)
		RCC1	147..195	CDD:278826	10/47 (21%)
		RCC1	199..251	CDD:278826	12/67 (18%)
		BTB	547..>635	CDD:295341
		BTB	684..795	CDD:279045
		BTB	697..798	CDD:197585
		SPOP_C_like	798..>834	CDD:269810
FMP25	NP_013178.1	ATS1	8..577	CDD:227511	83/411 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900