Protein Alignment CG8060 and EEA1

DIOPT Version :10

• Sequence 1: NP_611117.2
• Gene: CG8060 / 36824
• FlyBaseID: FBgn0034113
• Length: 1189
• Species: Drosophila melanogaster
• Sequence 2: XP_011537116.1
• Gene: EEA1 / 8411
• HGNCID: 3185
• Length: 1453
• Species: Homo sapiens
• Alignment Length: 1277
• Identity: 227/1277 - (17%)
• Similarity: 414/1277 - (32%)
• Gaps: 374/1277 - (29%)

  Fly    85 GQDYESGSSPLHRALYYGSIDCAVLLLRYGASLELLDEDTRCPLQAIC-RKC-DDDDLATDSQND 147
            |.|.:|.::|::      ::|         .:.|...|...|||   | ::| ...||....|.
Human    17 GSDLDSSATPIN------TVD---------VNNESSSEGFICPL---CMKRCITAIDLLEHYQK- 62

  Fly   148 VLVWGSNKNYNLGIGNEQNTN---TPQAVDFFRKSNLWLEQVALGAYHSLFCDKKGHLYAVGHGK 209
              |...|:.....:.|:.:..   .||.:.            :||:...||    .|..|| |..
Human    63 --VHDENETRGQELLNDSSVTGFICPQCMK------------SLGSADELF----KHYEAV-HDA 108

  Fly   210 GGRLGIGLENSLPAPKRVKVSSKLSGDSIQCISVS----RQHSLVL---------THQSLVFACG 261
            |...|.|.|::| |.||..|:  |....:|.:..|    :.:|..|         ..|......|
Human   109 GNDSGHGGESNL-ALKRDDVT--LLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDG 170

  Fly   262 LNTDHQLGVRDAAEQLTQ-------FKEVVALRDKGASDLVRVIACDQHSIAYGSRCVYVWGANQ 319
            |.||....::...:||.:       .|::..|.::.|:.|...|| |..| .|.........|.|
Human   171 LVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIA-DIKS-KYDEERSLREAAEQ 233

  Fly   320 GQFGINSNTPSITVPTLIKLPAKTTIRFVEANNAATVIYNEEKIITLCYADKTRYIKTPNYED-- 382
                                  |.|....|.|..||||.:.          ||..::.|..||
Human   234 ----------------------KVTRLTEELNKEATVIQDL----------KTELLQRPGIEDVA 266

  Fly   383 -----LKSISVMGGNLKNSTKGSAAALKLLMLTETNVVYLWYENTQQFYRCNFSPIRLHQIKKIL 442
                 |..:..:..|:....:..:..||    .|...:...|.:         |...:.|::..|
Human   267 VLKKELVQVQTLMDNMTLERERESEKLK----DECKKLQSQYAS---------SEATISQLRSEL 318

  Fly   443 YKCNQVMVLSEDGCVYRGKCNQIALPSSALQEKSRGSLDNWQDNDQNKTEISREH----VIRIEL 503
            .|..|      :..||..:..::....:.|.:|::...:|....:|:.|::..:|    |.:..:
Human   319 AKGPQ------EVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNI 377

  Fly   504 QRV-------------------PNIDRATYIFCDEGFSSFAV---LQESHTKYFR-----KPSLP 541
            |..                   .::.|......::|.::..:   |.|..|||..     |....
Human   378 QATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQ 442

  Fly   542 RREHSFKKLLHETSDCDAVHDVVFHVDGEKFAAHKFIIYSRAPGLRDLIRCYLDK-----DIYLN 601
            :||...:..|...|:.:.:|..:...:.:...||..:...|......|    :||     |:.|.
Human   443 QREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKL----MDKEQQVADLQLK 503

  Fly   602 FDHLTGKMFELILNHIYSSYW-----------------------PTEDDIDCIQQSLGPANPQQR 643
            ...|..::.|.:.|.....:.                       ..::|::.:.:.:|  :..|:
Human   504 LSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIG--DKDQK 566

  Fly   644 TRTCEMFLP-------------------------------------HLEKFQLVELTKYVQSYVR 671
            .:..|..|.                                     |..:.|:.:||:.:::...
Human   567 IQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSE 631

  Fly   672 DHQFPLPN-------------------------ARKLFNRLYRS-DHPELYDVRIVCKDGKVLGA 710
            .|:....|                         ..:|.::|..| :.....|::|..|...:|.|
Human   632 SHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSA 696

  Fly   711 HKCMLVARLEYFEMMFMHLWAERSSVTMEGVPAEYMEPVLDYLYS--LDNEAFCKQGYLETFL-- 771
            .......|.:    :..||...::::..:......:...||.:.:  .|.:..|.|  ||:.|
Human   697 EAAKTAQRAD----LQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQ--LESHLKE 755

  Fly   772 YNMITICDQYFIESLQNVCESLILDKISIRKCGEMLEFAAMYNCKILQKGCMDFICQNLSRVLCY 836
            |....:..:...|.|:...:.|..|.:.::...|          :.||
Human   756 YKEKYLSLEQKTEELEGQIKKLEADSLEVKASKE----------QALQ----------------- 793

  Fly   837 RSIEQCDGETLKCLNDHYRKMFKRVFDYRQITPFSEAIEDELLLSFVDGCDVDLNYRMDAESKLK 901
                  |.:..:.||....         .:.|..|:.:|.|  ...|....:||..:.:|...:|
Human   794 ------DLQQQRQLNTDLE---------LRATELSKQLEME--KEIVSSTRLDLQKKSEALESIK 841

  Fly   902 Q--AAKHKQKDLRKQD-------ARHQYEQ-----QAISSMMRSLSISESTQGTEVPSSPQDSAR 952
            |  ..:.::|.:.|||       .:.|:|:     |...:.::.:.:.:....||:.:.....::
Human   842 QKLTKQEEEKKILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSK 906

  Fly   953 SED--KNWSRVVDKKDQKRKLAETAL-KVNNTLKHEDPPTQELVPIERKPLKEQTPPPPSHETEP 1014
            ..|  ||.....:|::||.|.|...| |....|||:.....|....|:|.||:        ..|.
Human   907 VSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKK--------SLEK 963

  Fly  1015 TTPLSKSYNLDFSSLTPQ------SQKLSQKQRKRL---------SSESKSWRTNNPPLVE--QS 1062
            ....|....|:.:|:..|      :.|.::|:.::|         |||.|..:      :|  |.
Human   964 EKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQ------IEALQG 1022

  Fly  1063 STPVAVPNAWGVTTTPSGSFNDSFTSPTTGSSTDPTSFANMMRGHATSSTTPTDQSQSF----SR 1123
            ...:||..    .|..........|......:.:....:.:...:..|..|.......|    |.
Human  1023 ELKIAVLQ----KTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESE 1083

  Fly  1124 ILA--------DEKRQRESYERMRNKSLVHTQIEERAIAELR 1157
            :||        :||......:.:.|::.:..|  .:.|.||:
Human  1084 LLATRQDLKSVEEKLSLAQEDLISNRNQIGNQ--NKLIQELK 1123

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8060	NP_611117.2	ANKYR	<51..141	CDD:440430	13/57 (23%)
		ANK repeat	56..87	CDD:293786	1/1 (100%)
		ANK repeat	89..121	CDD:293786	4/31 (13%)
		ATS1	140..>355	CDD:444065	51/237 (22%)
		BTB_POZ	543..643	CDD:453885	18/127 (14%)
		BTB2_POZ_IBtk	691..802	CDD:349611	21/114 (18%)
		BACK_IBtk	798..857	CDD:350575	6/58 (10%)
EEA1	XP_011537116.1	GumC	<117..>349	CDD:442439	57/287 (20%)
		SMC_prok_B	<285..1006	CDD:274008	129/803 (16%)
		SMC_prok_B	651..>1382	CDD:274008	98/543 (18%)
		FYVE_EEA1	1389..1451	CDD:277269