DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG8060 and Als2

DIOPT Version :9

Sequence 1:NP_611117.2 Gene:CG8060 / 36824 FlyBaseID:FBgn0034113 Length:1189 Species:Drosophila melanogaster
Sequence 2:NP_001153420.2 Gene:Als2 / 74018 MGIID:1921268 Length:1651 Species:Mus musculus


Alignment Length:1393 Identity:269/1393 - (19%)
Similarity:457/1393 - (32%) Gaps:435/1393 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSAARTQEYDCTAKCR-LRQHGNAITAALTKRSI--DNQKLASFIFKTCGNFANIL-DDLGRSAV 61
            :|..:...:..||.|. ..|.|:|.|...:.:.:  :..|..|...|...:..:|. ::|...:.
Mouse   410 LSLKKVMNFYSTAPCETAAQSGSASTGPESLKDLREEQVKQESLQGKKSSSLMDIREEELEGGSR 474

  Fly    62 HMSASTARYEILEWLLNHGAYINGQDYESGSSPLHRALYYGSIDCAVLLLR-------YGASLEL 119
            .:|......::...||...|.:..:      :.:....|.|..|..:..||       .|...:|
Mouse   475 RLSLPGLLSQVSPRLLRKAARVKTR------TVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQL 533

  Fly   120 LDEDTRCPLQAICRKCDD------------DDLATDSQNDVLVWGSNKNYNLGIGNEQNTNTPQA 172
            ...|....||.:|.||.|            ..||..:::.|..||||....|| .:|..|..|:.
Mouse   534 GHGDVLPRLQPLCVKCLDGKEVIHLEAGGSHSLALTAKSQVYSWGSNTFGQLG-HSEFPTTVPRL 597

  Fly   173 VDFFRKSNLWLEQVALGAYHSLFC----DKKGHLYAVGHGKGGRLGIGLENSLPA-PKRVKVSSK 232
            .....::.:|  .||.|..:|||.    |.:..||     ..||......::||. |...|....
Mouse   598 SKVSSENGVW--SVAAGQDYSLFLVDTEDFQPGLY-----YSGRQDRAEGDTLPENPSGTKTPVL 655

  Fly   233 LSGDSIQCIS---VSRQHSLVLTHQSLV-FACGLNTDHQLG--VRDAAEQLTQFKE-----VVAL 286
            ||...:..||   ..:...|.|..:::: :...|   |:|.  .|....:|::.|.     :::|
Mouse   656 LSCSKLGYISRVTAGKDSYLALVDKNIMGYIASL---HELASTERRFYSKLSEIKSQILRPLLSL 717

  Fly   287 RDKGASDLVRVIACDQHSIAYGSRCVYVWGANQGQFGINSNTPSITVPTLIKLPAKTTIRFVEAN 351
            .:.|....|:::  .:.:..:...|..:     ||.|.:.::                  :::..
Mouse   718 ENLGTVTTVQLL--QEVASRFSKLCYLI-----GQHGASLSS------------------YLQGM 757

  Fly   352 NAAT--VIYNEEKIITLCYADKTRYIKTPNYEDLKSISVMGG---------NLKNSTKGSAAALK 405
            ..|:  ||.....:....|   |.|..:     :.:..||||         :..|..:      :
Mouse   758 KEASSLVIMKHSSLFLDSY---TEYCTS-----VSNFLVMGGFQLLAKPAIDFLNKNQ------E 808

  Fly   406 LLM-LTETNVVYLWYENTQQFYRCN---FSPI-RLHQIKKILYK---CNQV-----MVLSEDGCV 457
            ||. |:|.|     .||||.....|   |.|| |||...|:|.|   |.:|     ..|.:....
Mouse   809 LLQDLSEVN-----DENTQLMEILNMLFFLPIRRLHNYAKVLLKLATCFEVTSPEYQKLQDSSSC 868

  Fly   458 YR------------------------GKC--------NQIALPSS----ALQEKSRGSLDNW--Q 484
            |.                        ||.        .::...||    :||...|.|: ||  .
Mouse   869 YESLALHLGKKRKEAEYTLSFWKTFPGKMTDSLRKPERRLLCESSNRALSLQHAGRFSV-NWFIL 932

  Fly   485 DNDQ-NKTEISREHVIRIEL-------QRVPNIDRATYIFCDEGFSSFAVLQESHTKYFR----- 536
            .||. ...:.|..||..:..       :...:::.......:|.|:..:...:..||:.|     
Mouse   933 FNDALVHAQFSTHHVFPLATLWAEPLSEEAGSVNGLKITTPEEQFTLISSTPQEKTKWLRAISQA 997

  Fly   537 -----------------------KPSLPR-REHSFKKLLHETSDCDAVHD------------VVF 565
                                   :|.:.| .:::|.|   :|...||.:|            |:.
Mouse   998 VDQALRGTSDFPLYGGGSSVQRQEPPISRSAKYTFYK---DTRLKDATYDGRWLSGKPHGRGVLK 1059

  Fly   566 HVDGEKFAAHKFIIYSRAPGLRDLIRCY------LDKDIYLNFDHLTG--KMFELILNHIYSSYW 622
            ..||:.::.    ::..  ||.|....|      |:|:     ||..|  |..::....:| ||.
Mouse  1060 WPDGKMYSG----MFRN--GLEDGYGEYRIPNKALNKE-----DHYVGHWKEGKMCGQGVY-SYA 1112

  Fly   623 PTEDDIDCIQQSLGPANPQQRTRTCEMFLPHLEKFQLV-----------ELT---KYVQSYVRD- 672
            ..|....|.|.::...:...|:.......|.:...|.|           ::|   ||:..:..| 
Mouse  1113 SGEVFEGCFQDNMRHGHGLLRSGKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDV 1177

  Fly   673 --------HQFPLP-----NARKLF-NRLYRSDHPELYDVRIVCKDGKVLGAHKCMLVARLEYFE 723
                    .||.|.     :..|:. |.:..|:...:|:...  .|...|.....:.:...:|.|
Mouse  1178 CQGNGVVVTQFGLYYEGNFHLNKMMGNGVLLSEDDTIYEGEF--SDDWTLSGKGTLTMPHGDYIE 1240

  Fly   724 MMFMHLWAERSSVTMEGVPAEYMEPVLDYLYSLDNE---AFCKQGYLETFLYNMITICDQ----Y 781
            ..|...|.....:|     ..|.:|   .||..|.:   ||.|.|       |:....|:    .
Mouse  1241 GYFSGEWGSGIKIT-----GTYFKP---SLYESDKDKPKAFRKLG-------NLAVAADEKWRAV 1290

  Fly   782 FIESLQNV-CES-------LILDKISIRKCGEMLEFAAMYNCKILQKGCMDFICQNLSRVLCYRS 838
            |.|..:.: |||       ...|.|::          |:...:...|...:.:.::.::.|    
Mouse  1291 FEECWRQLGCESPGQGEVWKAWDNIAV----------ALTTNRRQHKDSPEILSRSQTQTL---- 1341

  Fly   839 IEQCDGETLKCLNDHYRKMFKRVFDYRQITPFSEAIEDELLLSFVDGCDVDLN------------ 891
                  |:|:.:..|             |..||....|::....:..||..|:            
Mouse  1342 ------ESLEYIPQH-------------IGAFSVEKYDDIKKYLIKACDTPLHPLGRLVETLVAV 1387

  Fly   892 YRM-----DAESKLKQAAKHKQKDLRKQDARHQYEQQAISSMMRSLSISESTQGTEVP-SSPQDS 950
            |||     .|..:|.|.|..:.|...|:          |..::|.|......:|:.:| |:|..:
Mouse  1388 YRMTYVGVGANRRLLQEAVKEIKSYLKR----------IFQLVRFLFPELPEEGSTIPLSAPLPT 1442

  Fly   951 ARSEDKNWSRVVDKKDQKRKLAETALKVNNTLKHEDPPTQELVPIERKPLKEQTPPPPSHETEPT 1015
            .|.     |....|.|.:.:..|....|.:        :..|:|:    |..:..|         
Mouse  1443 GRR-----SFCTGKSDSRSESPEPGYVVTS--------SGLLLPV----LLPRLYP--------- 1481

  Fly  1016 TPLSKSYNLDFSSLTPQSQKLSQKQRKRLSSESKSW----RTNNPPLVEQSSTPVAVPNAWGVTT 1076
             ||...|.||             ..|:    |...|    |.|..|.:............|..|.
Mouse  1482 -PLFMLYALD-------------NDRE----EDIYWECVLRLNKQPDIALLGFLGVQKKFWPATL 1528

  Fly  1077 TPSGSFNDSFTSPTTGSSTDPTSFANMMRGHATSST--TPTDQSQSFSRILADEKRQRESYERMR 1139
            :..|.      |....|:|....||:.:......||  ||:|:.          |..::::|   
Mouse  1529 SILGE------SKKVLSTTKDACFASAVECLQQISTTFTPSDKL----------KVIQQTFE--- 1574

  Fly  1140 NKSLVHTQIEERAIAELRE--FYNVDNI 1165
                   :|.:..:|.|:|  .:::|::
Mouse  1575 -------EISQSVLASLQEDFLWSMDDL 1595

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8060NP_611117.2 ANK <46..138 CDD:238125 20/111 (18%)
ANK repeat 56..87 CDD:293786 5/30 (17%)
Ank_4 57..111 CDD:290365 7/53 (13%)
ANK repeat 89..121 CDD:293786 7/38 (18%)
Ank_2 95..>138 CDD:289560 14/61 (23%)
RCC1 147..195 CDD:278826 15/47 (32%)
RCC1 199..251 CDD:278826 13/55 (24%)
BTB 547..>635 CDD:295341 25/107 (23%)
BTB 684..795 CDD:279045 26/126 (21%)
BTB 697..798 CDD:197585 24/115 (21%)
SPOP_C_like 798..>834 CDD:269810 3/35 (9%)
Als2NP_001153420.2 RCC1 1. /evidence=ECO:0000305 59..108
RCC1_2 93..122 CDD:290274
RCC1 2. /evidence=ECO:0000305 109..167
RCC1 109..165 CDD:278826
RCC1 3. /evidence=ECO:0000305 169..218
RCC1 170..216 CDD:278826
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 425..462 7/36 (19%)
RCC1 4. /evidence=ECO:0000305 519..570 12/50 (24%)
RCC1 521..568 CDD:278826 10/46 (22%)
RCC1 5. /evidence=ECO:0000305 572..621 17/51 (33%)
RCC1 573..619 CDD:278826 16/48 (33%)
RhoGEF 689..873 CDD:295373 47/230 (20%)
PH_alsin 899..1004 CDD:241423 18/105 (17%)
PH 920..998 CDD:278594 15/78 (19%)
COG4642 1043..1182 CDD:226989 28/150 (19%)
MORN 1 1043..1065 4/21 (19%)
MORN 1043..1063 CDD:280628 2/19 (11%)
MORN 2 1066..1088 4/27 (15%)
MORN 3 1094..1116 5/22 (23%)
MORN 1094..1114 CDD:280628 5/20 (25%)
MORN 4 1117..1139 3/21 (14%)
MORN 5 1145..1167 3/21 (14%)
COG4642 1166..>1266 CDD:226989 21/109 (19%)
MORN 6 1169..1191 4/21 (19%)
MORN 7 1192..1214 3/21 (14%)
MORN 8 1215..1238 3/24 (13%)
VPS9 1548..1647 CDD:280383 12/68 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5184
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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