Protein Alignment CG8060 and ALS2

DIOPT Version :10

• Sequence 1: NP_611117.2
• Gene: CG8060 / 36824
• FlyBaseID: FBgn0034113
• Length: 1189
• Species: Drosophila melanogaster
• Sequence 2: NP_065970.2
• Gene: ALS2 / 57679
• HGNCID: 443
• Length: 1657
• Species: Homo sapiens
• Alignment Length: 1183
• Identity: 203/1183 - (17%)
• Similarity: 349/1183 - (29%)
• Gaps: 445/1183 - (37%)

  Fly   185 QVALGAYHSLFCDKKGHLYAVGHGKGGRLGIGLENSLP--------APKRVKVSSKLSGDSIQCI 241
            |.|||..|.:...:.|.:|:.|             :||        .|....:.:.|.|..:..:
Human    45 QAALGVKHGVLLTEDGEVYSFG-------------TLPWRSGPVEICPSSPILENALVGQYVITV 96

  Fly   242 SVSRQHSLVLTHQSLVFACGLNTDHQLGVRDAAEQLTQFKEVVALRDKGASDLVRV----IAC-D 301
            :....||..:|...:.:..|.|:..|..|  |.:|.......|::.|..||.|:.|    :|| :
Human    97 ATGSFHSGAVTDNGVAYMWGENSAGQCAV--ANQQYVPEPNPVSIADSEASPLLAVRILQLACGE 159

  Fly   302 QHSIAYG-SRCVYVWGANQGQFGINSNTPSITVPTLIKLPAKTTIRFVEANNAATVIYNEEKIIT 365
            :|::|.. ||.::.||.. .|.|:.:....:|.|..::..|...:..|......::      .:.
Human   160 EHTLALSISREIWAWGTG-CQLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSL------ALV 217

  Fly   366 LCYADKTRYIKTPNYEDLKSISVMGGNLKNSTKGSAAALKLLMLTETNVVYLWYENTQQFYRCNF 430
            .|...          :|||.:.                                      .|||
Human   218 QCLPS----------QDLKPVP--------------------------------------ERCN- 233

  Fly   431 SPIRLHQIKKILYKCNQVM----------VLSEDGCVYRGKC---NQIALPSSALQEKSRGSLDN 482
                         :|:|::          ::|:..|...|..   :|....:|.....|..:||.
Human   234 -------------QCSQLLITMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDR 285

  Fly   483 WQDNDQNKTEISREHVIRIELQRV-------------PNIDRATYIFCDEGFSSFAVLQESHTKY 534
            .::..:| |.::.:..:..||..|             .|:...|.|.......|:...| :..:|
Human   286 QEEVFEN-TLVANDQSVATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQ-AVNEY 348

  Fly   535 FRKPSLPRREHSFKKLLHETSDCDAVHDVVFHVDGEKFAAHKFIIYSRAPGLRD----------- 588
            .||.|    :||.::        |:.|       |||....:.::....|.|..
Human   349 LRKLS----DHSVRE--------DSEH-------GEKPVPSQPLLEEAIPNLHSPPTTSTSALNS 394

  Fly   589 -LIRCYLDKDIYLNFDHLTGKM-FELILNHIYSSYWPTEDDIDCIQQSLGP-----ANPQQ---- 642
             ::.|.....:.:...:..|.: .:.::|  :.|..|.|........::||     :..:|
Human   395 LVVSCASAVGVRVAATYEAGALSLKKVMN--FYSTTPCETGAQAGSSAIGPEGLKDSREEQVKQE 457

  Fly   643 -------------RTRTCE-----MFLPHL--------------EKFQLVELTKYVQSYVRDHQF 675
                         |....|     :.||.|              .|.:.|.||   .:|..:...
Human   458 SMQGKKSSSLVDIREEETEGGSRRLSLPGLLSQVSPRLLRKAARVKTRTVVLT---PTYSGEADA 519

  Fly   676 PLPNARKLF--------NRLYRSD-HPELYDVRIVCKDGKVL------GAHKCMLVARLEYFEMM 725
            .||:.|...        .:|...| .|.|..:.:.|.|||.:      |.|...|.|:.:.:.
Human   520 LLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYS-- 582

  Fly   726 FMHLWAERSSVTMEGVPAEYMEPVL----------------DY-LYSLDNEAF------------ 761
                |...:...:.........|.|                || |:.:|.|.|
Human   583 ----WGSNTFGQLGHSDFPTTVPRLAKISSENGVWSIAAGRDYSLFLVDTEDFQPGLYYSGRQDP 643

  Fly   762 --------------------C-KQGYLE---------------------TFLYNMITICDQYF-- 782
                                | |.||:.                     ..|:.:.|...:::
Human   644 TEGDNLPENHSGSKTPVLLSCSKLGYISRVTAGKDSYLALVDKNIMGYIASLHELATTERRFYSK 708

  Fly   783 -----------------------IESLQNVC---------------------------------- 790
                                   ::.||.|.
Human   709 LSDIKSQILRPLLSLENLGTTTTVQLLQEVASRFSKLCYLIGQHGASLSSFLHGVKEARSLVILK 773

  Fly   791 -ESLILDKISIRKCGEMLEFAAMYNCKILQKGCMDFICQNLSRVLCYRSIEQCDGETLKCLNDHY 854
             .||.||..: ..|..:..|..|...::|.|..:||:.:|...:.....:...:.:.::.||..:
Human   774 HSSLFLDSYT-EYCTSITNFLVMGGFQLLAKPAIDFLNKNQELLQDLSEVNDENTQLMEILNTLF 837

  Fly   855 RKMFKRVFDYRQITPFSEAIEDELLLSFVDGCDVDLNYRMDAESKLKQAAKHKQKDLRKQDARHQ 919
            ....:|:.:|.::           ||......:|              |:...||   .||:...
Human   838 FLPIRRLHNYAKV-----------LLKLATCFEV--------------ASPEYQK---LQDSSSC 874

  Fly   920 YEQQAISSMMRSLSISESTQG--TEVPSSPQDSARSEDKNWSRVVDKKDQKRKLAETA------- 975
            ||..|: .:.|....:|.|.|  ...|....||.|            |.::|.|.|::
Human   875 YECLAL-HLGRKRKEAEYTLGFWKTFPGKMTDSLR------------KPERRLLCESSNRALSLQ 926

  Fly   976 ----------LKVNNTLKHEDPPTQELVPIE---RKPLKEQ---------TPPPPSHETEPTTPL 1018
                      :..|:.|.|....|..:.|:.   .:||.|:         |.|........:||.
Human   927 HAGRFSVNWFILFNDALVHAQFSTHHVFPLATLWAEPLSEEAGGVNGLKITTPEEQFTLISSTPQ 991

  Fly  1019 SK-------SYNLD-----FSSLTPQSQKLS-QKQRKRLSSESKSWRTNNPPLVEQSSTP---VA 1067
            .|       |..:|     .|.|.|.....| |:|...:|..:|.....:|.|.:.:...   ..
Human   992 EKTKWLRAISQAVDQALRGMSDLPPYGSGSSVQRQEPPISRSAKYTFYKDPRLKDATYDGRWLSG 1056

  Fly  1068 VPNAWGVTTTPSG 1080
            .|:..||...|.|
Human  1057 KPHGRGVLKWPDG 1069

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8060	NP_611117.2	ANKYR	<51..141	CDD:440430
		ANK repeat	56..87	CDD:293786
		ANK repeat	89..121	CDD:293786
		ATS1	140..>355	CDD:444065	42/183 (23%)
		BTB_POZ	543..643	CDD:453885	18/134 (13%)
		BTB2_POZ_IBtk	691..802	CDD:349611	33/248 (13%)
		BACK_IBtk	798..857	CDD:350575	10/58 (17%)
ALS2	NP_065970.2	ATS1	<39..219	CDD:444065	42/195 (22%)
		RCC1 1. /evidence=ECO:0000305	59..108		10/61 (16%)
		RCC1 2. /evidence=ECO:0000305	109..167		16/59 (27%)
		RCC1 3. /evidence=ECO:0000305	169..218		9/55 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	432..480		5/47 (11%)
		RCC1 4. /evidence=ECO:0000305	525..576		12/50 (24%)
		ATS1	<527..>683	CDD:444065	25/161 (16%)
		RCC1 5. /evidence=ECO:0000305	578..627		6/54 (11%)
		RhoGEF	695..879	CDD:470622	31/212 (15%)
		PH_alsin	905..1010	CDD:241423	22/116 (19%)
		COG4642	<1049..1249	CDD:443680	5/21 (24%)
		MORN 1	1049..1071		5/21 (24%)
		MORN 2	1072..1094
		MORN 3	1100..1122
		MORN 4	1123..1145
		MORN 5	1151..1173
		MORN 6	1175..1197
		MORN 7	1198..1220
		MORN 8	1221..1244
		VPS9	1552..1656	CDD:460489