DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8060 and ibtk

DIOPT Version :9

Sequence 1:	NP_611117.2	Gene:	CG8060 / 36824	FlyBaseID:	FBgn0034113	Length:	1189	Species:	Drosophila melanogaster
Sequence 2:	XP_005157916.1	Gene:	ibtk / 572463	ZFINID:	ZDB-GENE-030131-6246	Length:	1332	Species:	Danio rerio

Alignment Length:	1373	Identity:	369/1373 - (26%)
Similarity:	574/1373 - (41%)	Gaps:	269/1373 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DCTAKCRLRQHGNAITAALTKRSIDNQKLASFIFKTCGNFANILDDLGRSAVHMSASTARYEILE 74
            |||.|||..:|.:.:.:|||..|  ...|.:|:...|.|.|.:.|:.||:|:|::||..:.|:|:
Zfish     7 DCTPKCRSERHADEVISALTSGS--EACLRAFLSVHCHNSATLRDEFGRTALHLAASMGKRELLQ 69

  Fly    75 WLLN--HGAYINGQDYESGSSPLHRALYYGSIDCAVLLLRYGASLELLDEDTRC---------PL 128
            |||:  | |.:..:|.|||.:.|||:.:||.|.|.:.|::.|.||.:.|::...         |.
Zfish    70 WLLDCKH-ADLLAKDKESGWTALHRSAFYGQIHCLITLIKRGGSLSMQDKEGLSVLDLTMKDRPA 133

  Fly   129 QAICRKCDDDDLATDSQNDVLVWGSNKNYNLGIGNEQNTNTPQAVDFFRKSNLWLEQVALGAYHS 193
            ..:.:..|        ..:|..||:|.|::||.||:::...|:.||.|.:|.::::||.|..:||
Zfish   134 HVVYQNTD--------PTEVYTWGNNTNFSLGHGNQESRQHPEIVDLFSRSGIYVKQVVLCKFHS 190

  Fly   194 LFCDKKGHLYAVGHGKGGRLGIGLENSLPAPKRVKVSSKLSGDSIQCISVSRQHSLVLTHQSLVF 258
            :|..:||.:|..|||:|||||.|.||:...|:.|:  ..||....| |:.:|.|::|||.:..|:
Zfish   191 VFLSQKGQVYTCGHGQGGRLGHGDENTYLVPRMVE--GLLSHHCSQ-IAAARDHTVVLTEEGYVY 252

  Fly   259 ACGLNTDHQLGVRDAAEQLTQFKEVVALRDKGASDLVRVIACDQHSIAYGSRCVYVWGANQGQFG 323
            ..||||.||||:.......:..|:|.:...||.| ::.|.|...|::.:....||..|.|.||.|
Zfish   253 TFGLNTHHQLGLGPPPTSSSVPKQVTSKSLKGRS-VIGVAAGRFHTVLWTRDAVYTVGLNGGQLG 316

  Fly   324 I---NSNTPSITVPTLIK--LPAKTTIRFVEANNAATVIYNEEKIITLCYADKTRYIKTPNYE-- 381
            .   .:....:|||..:.  |....||..|.|:|.|||          |..||.......:|:
Zfish   317 YLLEPNGEKCVTVPRQVSALLHKDVTISMVAASNGATV----------CVTDKGDVYLLVDYQCK 371

  Fly   382 -------DLKSISVMGGNLKNST------KGSAAALKLLMLTETNVVYLWYENTQQFYRCNFSPI 433
                   :||.|.|.||:|.:.|      .|....|.:|.|.||..|:.|.........|.::..
Zfish   372 KLASKQLNLKKILVSGGSLDHRTDPQLLHDGGGEKLVILALDETGRVFSWRSVGTSARLCRWAYG 436

  Fly   434 RLHQIKKILYKCNQVMVLSEDGCVYRGKCNQIALPSSALQEKSRGSLDNWQDNDQNKTEISREH- 497
            |...:..|....|.:|.:::||..:.|:.        ..|.|..|       :.::..|:|...
Zfish   437 RQVFVSDIALSKNSMMFVTQDGEGFSGQW--------LGQYKKAG-------DKKDGLEVSSNSD 486

  Fly   498 ----VIRIELQRVPNIDRATYIFCDEGFSSFAVLQ-ESHTKYFRKPSLPRREHS--FKKLLHETS 555
                ..||.|:::..:.||..|..|....:|.||| :..|..:..||:.....|  .::||.|..
Zfish   487 GGSVFERIRLEKLHYVHRAVSIVMDSSGRNFGVLQVDPKTSLYEVPSISASSFSQHLQRLLAEAD 551

  Fly   556 DCDAVHDVVFHVDGEKFAAHKFIIYSRAPGLR-------------------DLIRCYLDKDIYLN 601
            :.|.:||:........|.|||:|:..|:...|                   |.:.|.|     |.
Zfish   552 ETDNIHDITLQAGDRTFPAHKYILSVRSDFFRKILLPEAEREGDGEVRRGEDAVGCDL-----LV 611

  Fly   602 FDHLTGKMFELILNHIYSSYWPTEDDIDCIQQSLGP----ANPQQRTRTCEMFLPH--------- 653
            .:.:..::.|..||.||:      |..|.:.....|    .|...:....|:..|.
Zfish   612 LEKIPPELLEQALNFIYT------DSCDMLVDGACPIIPRCNRSSKPEPEEVLEPESEQLIHSLQ 670

  Fly   654 ---LEKFQLVEL------------------------TKYVQSYVRDHQFPLPNARKLFNRL---- 687
               |||...:::                        .|.|::...:.|.|:...:.:..:|
Zfish   671 VLGLEKRSALDVYRSLPVQMRKEAEKPKTAGKNNKSGKKVKNVAENGQNPVKMLQGVAKKLGLGS 735

  Fly   688 ---------------------YRSDHP--------ELYDVRIVCKDGKVLGAHKCMLVARLEYFE 723
                                 .|.:.|        .|.||.:...|||....|||:|.||||||.
Zfish   736 LSARLDGVKFENGKISVGLQKKRGNKPRFTLKKGSHLCDVTLRSVDGKEFSCHKCILCARLEYFN 800

  Fly   724 MMFMHLWAERSSVTMEGVP--AEYMEPVLDYLYSLDNEAFCKQGYLETFLYNMITICDQYFIESL 786
            .|....|.|.:|.:...:|  :|.::.:|:|:|: |.....:......|:.|::.:.||..|..|
Zfish   801 SMLGSSWMEATSCSALSLPISSEVLQVILEYIYT-DESHTVRDAVNMEFVCNVLVVADQLLITRL 864

  Fly   787 QNVCESLILDKISIRKCGEMLEFAAMYNCKILQKGCMDFICQNLSRVLCYRSIEQCDGETLKCLN 851
            :.:||.:|.:|:.::...|:|||:.:||.:.|:..|:.||..|::.:|..:::|....:.|..:.
Zfish   865 KEICEVVIAEKLMLKNAAELLEFSTIYNAEQLKLSCLQFIVLNMAALLESKALEILSDDVLVDVA 929

  Fly   852 DHYRKMFKRVFDYRQITPFSE-----AIEDELLLSFVDGCDVDLNYRMDAESKLKQA-AKHKQKD 910
            ..||:... ....|.|||:::     |.||:...|.|| |.........:||.||:| .:.|:|.
Zfish   930 AAYRRTIP-AMQRRLITPYADAPDLSAYEDQEWDSAVD-CKSTSEADHSSESLLKKAKMRAKKKP 992

  Fly   911 LRKQDARHQYE---------QQAISSMMRSLSISESTQ--GTEVPSSPQDSAR-----SEDKNWS 959
            .|:.|:...|.         ...|.|....::.|..|.  |..|.:|..||.:     ..:.::.
Zfish   993 RRRSDSSGGYNLSDIIQSSPNDVIQSPPNYVTQSPPTPGLGNSVKASSVDSLQELIMSDSEGSYM 1057

  Fly   960 RVVDKKD------QKRKLAETALKV---NNTLKHEDPPTQELVPIERKPLKEQTPPP-----PSH 1010
            .|...:|      |..:.....||.   ...||:...|.|...| |..|..:..|.|     ...
Zfish  1058 AVGSPRDLQSPVFQDERRGPAGLKTPPGTPVLKNGPVPVQSSTP-EHIPTVKARPAPVLDLRAIM 1121

  Fly  1011 ETEP------TTPLSKSYNLDFSSLTPQSQKLSQKQRKRLSSESKSWRTNNPPLVEQSSTPVAVP 1069
            |.|.      .||.:.|.:...|.::....||||||||.|:..|:...|.:   |...|.|.|.|
Zfish  1122 EMEANSLNLGATPKAISGSSSSSKISIIPSKLSQKQRKMLAQASREGSTES---VSAKSPPPAAP 1183

  Fly  1070 ----NAWGVTTTP---SGSFNDSFTSPTTGSSTDPTSFANMMRGHATSST--------------- 1112
                ..|.....|   |.||.|............|.|  .:..|.|.||.
Zfish  1184 IKPVKTWSTAVQPSLSSCSFRDLLAEEERRGKAPPVS--PVAAGPALSSAKRVTFKCAENSDPEK 1246

  Fly  1113 -----------TPTDQSQSFSRILADEKRQRESYERMRNKSLVHTQIEERAIAELREFYNVDNID 1166
                       :|...| :|:.|:.:|::|..:..|.|:|.|...||||||:.:|...||..|..
Zfish  1247 PAGPWVLRAAGSPPSMS-TFASIVEEERQQEAALIRSRDKPLALIQIEERAVQDLLIHYNAFNNP 1310

  Fly  1167 DETITIAR 1174
            ||.|.:.|
Zfish  1311 DELILVER 1318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8060	NP_611117.2	ANK	<46..138	CDD:238125	35/102 (34%)
		ANK repeat	56..87	CDD:293786	13/32 (41%)
		Ank_4	57..111	CDD:290365	24/55 (44%)
		ANK repeat	89..121	CDD:293786	14/31 (45%)
		Ank_2	95..>138	CDD:289560	14/51 (27%)
		RCC1	147..195	CDD:278826	19/47 (40%)
		RCC1	199..251	CDD:278826	22/51 (43%)
		BTB	547..>635	CDD:295341	24/106 (23%)
		BTB	684..795	CDD:279045	37/145 (26%)
		BTB	697..798	CDD:197585	34/102 (33%)
		SPOP_C_like	798..>834	CDD:269810	11/35 (31%)
ibtk	XP_005157916.1	ANK	24..136	CDD:238125	40/114 (35%)
		Ank_2	24..117	CDD:289560	38/95 (40%)
		ANK repeat	51..83	CDD:293786	13/32 (41%)
		ANK repeat	85..117	CDD:293786	14/31 (45%)
		RCC1	144..193	CDD:278826	19/48 (40%)
		RCC1	196..245	CDD:278826	22/51 (43%)
		RCC1	248..300	CDD:278826	17/52 (33%)
		BTB	557..>634	CDD:279045	19/87 (22%)
		BTB	558..>634	CDD:197585	18/86 (21%)
		BTB	766..869	CDD:279045	32/103 (31%)
		BTB	774..869	CDD:197585	31/95 (33%)
		SPOP_C_like	876..932	CDD:269810	14/55 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574804
Domainoid	1	1.000	85	1.000	Domainoid score	I8158
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34661
Inparanoid	1	1.050	405	1.000	Inparanoid score	I1867
OMA	1	1.010	-	-		QHG47467
OrthoDB	1	1.010	-	-		D168140at33208
OrthoFinder	1	1.000	-	-		FOG0006506
OrthoInspector	1	1.000	-	-		oto40443
orthoMCL	1	0.900	-	-		OOG6_105763
Panther	1	1.100	-	-	LDO	PTHR22872
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5481
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910