Protein Alignment CG8060 and eea1

DIOPT Version :10

• Sequence 1: NP_611117.2
• Gene: CG8060 / 36824
• FlyBaseID: FBgn0034113
• Length: 1189
• Species: Drosophila melanogaster
• Sequence 2: XP_003200485.1
• Gene: eea1 / 492695
• ZFINID: ZDB-GENE-041111-270
• Length: 1398
• Species: Danio rerio
• Alignment Length: 898
• Identity: 182/898 - (20%)
• Similarity: 304/898 - (33%)
• Gaps: 232/898 - (25%)

  Fly   472 LQEKSRGSLDNWQ-----------DNDQNKTEI------SREHVIRIELQRVPNIDRATYIFCDE 519
            ||:.:.|.|...|           |.||....:      |:|.|.::|.:|.   |....|...|
Zfish   483 LQQSTNGKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKESVSQLETERE---DLCAKIQAGE 544

  Fly   520 GFSSFA--------VLQESHTKYFRKPSLPRREHSFKKL---LHE------------TSDCDAVH 561
            |.::..        .|||..|:...|  |..:..|.|:.   |||            ...|..:.
Zfish   545 GEAALLNQLQEKNHSLQEQITQLTDK--LKNQSESHKQAQDNLHEQVQEQKTHLRSAQDRCQGLE 607

  Fly   562 DVVFHVD------GEKFA-------AHKFIIYSRAPGLRDLIRCYLDKDIYLNFDHLTGKMFELI 613
            ..|..::      .||.|       |...::.| |...::..|..|:..:....:.|..|..|
Zfish   608 TTVTELNTQLTESREKIAQLDTQLKAKTEMLLS-AEAAKNAQRADLESHLETAQNALQDKQQE-- 669

  Fly   614 LNHIYSSYWP-----TEDDIDCIQQSLGPANPQQRTRTCEMFLPHLE---KFQLVELTKY----- 665
            |:.:.:....     ||....|.|...|..:.:.:..|.|..:..|:   |...||||:.
Zfish   670 LSKVQAQLEEQARRLTEKQEQCSQLENGLKDSRDKLMTAEQRIETLQTQTKKAEVELTELRSGRE 734

  Fly   666 ----VQSYVRDHQFPLPNARKLFNRLYRSD-------HPELYDVRIVCKDGKVLGAHKCMLVARL 719
                .||.::.....|....|..|||..|:       ..||.      |....|...:    .:|
Zfish   735 QAQKEQSSLKKQISELEMKTKELNRLLDSEKQGASTQQEELK------KKSSALTETR----QKL 789

  Fly   720 EYFEMMFMHLWAERSSVTMEGVPAEYMEPVLD-YLYSLDNEAFCKQGYLETFLYNMITICDQYFI 783
            |..|.....|.|....::.||   :..:..|| .:..|.::....||..||.:..:.|:     .
Zfish   790 EKAEQERGALQANLDKLSQEG---QKQQAELDKKVQGLSSDLQKTQGEKETLVKEVATV-----K 846

  Fly   784 ESLQNVCESL-----ILDKISIRKCGE--MLEFAAMYNCKI---LQKGCMDFICQNLSRV--LCY 836
            |:|....::|     .|||   .|.|.  .||.......|:   |||. .:...:.||.|  |..
Zfish   847 EALSKASKALKESQTQLDK---EKKGSKATLEEKEKVFQKVQQELQKN-SEATSKELSNVKGLLE 907

  Fly   837 RSIE-----------------QCDGETLKCLNDHYRKMFKRVFDYRQITPFSEAIEDELLLSFVD 884
            :|||                 ||. :||| ..:...:..:.....|| ..||:.::.  |.:.|.
Zfish   908 KSIEAEKSLQSQLTALNAQLKQCQ-DTLK-EKEKSEQQLQAELKTRQ-GSFSQEVKK--LKTQVS 967

  Fly   885 GCDVDLNYRMDAESKLKQAAKHKQKDLRKQDARHQYEQQAISSMMRSLSISEST---QGTEVPSS 946
            .....|..:.:.|:|.|:......|||..:..|....|:.......||:..:|.   :.:|:.:.
Zfish   968 ELQASLAKKTEEEAKQKEQITALSKDLSSEKNRCAELQKTSDGTKESLTALQSDYYGKESELSAV 1032

  Fly   947 PQDSARSEDK------------NWSRVVDKKDQKRKLAETALKVNNTLKHEDPPTQELVPIERKP 999
            .||....|:|            |.....:.:.|:.|...||::::  |...|...::.|...:|.
Zfish  1033 RQDLKVCEEKLVLAQEELVTNRNQLSAYETQIQELKTGHTAMEID--LSKRDEKIKQQVETLQKL 1095

  Fly  1000 LKEQTPPPPSHETEPTTPLSKSYNLDFSSLTPQSQKLSQKQRKRLSSESKSWRTNNPP------- 1057
            .|:|      .:||......|:...:..    :||...:|.:.:||::.|:....|..
Zfish  1096 QKQQ------GQTEEQLKKEKAQCEELR----ESQSALEKDKNKLSADLKTLAEKNEKELKDLQA 1150

  Fly  1058 --------------LVEQSSTPVAVPNAWGVTTTPSGSFNDSFTSPTTGS-----STDPTSFANM 1103
                          .||.:...|.........|..|...|:......|..     :::..:...|
Zfish  1151 AKQLLIQQKVEMQGKVEAAQASVEKEQREHQKTRDSIKQNEQQLKAETNKIKQQLASEVKAKEEM 1215

  Fly  1104 MRGHATSSTTPTDQSQSFSRILADEKRQRESYER-----------MRNKSLV------HTQIEER 1151
            :|....:....:.|..:.:..:|..||:.:|.:|           :|.:..|      :.|.|.|
Zfish  1216 VRQREEAEVKMSMQVTALNENVATLKREWQSSQRRVGELEKQTDELRGEIAVLEATVQNNQDERR 1280

  Fly  1152 AI---------------AELREFYNVDNIDDETITIARVSRPSDINFSIWLRQ 1189
            |:               |::.|...  .:||.|..:..:.|.   |.|:.::|
Zfish  1281 ALLERCVQGEGEMEKLQAKMLEMRR--KLDDTTAAMQELGRE---NQSLQIKQ 1328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8060	NP_611117.2	ANKYR	<51..141	CDD:440430
		ANK repeat	56..87	CDD:293786
		ANK repeat	89..121	CDD:293786
		ATS1	140..>355	CDD:444065
		BTB_POZ	543..643	CDD:453885	24/132 (18%)
		BTB2_POZ_IBtk	691..802	CDD:349611	25/123 (20%)
		BACK_IBtk	798..857	CDD:350575	20/82 (24%)
eea1	XP_003200485.1	SMC_prok_B	<71..391	CDD:274008
		SMC_prok_B	238..929	CDD:274008	103/475 (22%)
		Smc	624..1284	CDD:440809	141/701 (20%)
		FYVE_EEA1	1334..1396	CDD:277269