DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8060 and ca

DIOPT Version :9

Sequence 1:	NP_611117.2	Gene:	CG8060 / 36824	FlyBaseID:	FBgn0034113	Length:	1189	Species:	Drosophila melanogaster
Sequence 2:	NP_001287593.1	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster

Alignment Length:	1077	Identity:	209/1077 - (19%)
Similarity:	347/1077 - (32%)	Gaps:	357/1077 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RLRQHGNAITAALTKRSIDNQKLASF------IFKTCGNFANILDDLGRSAVHMSASTARYE-IL 73
            ||.:..|..:.||......|...|..      :|:.|   .::::......:||.:...:|: |:
  Fly  1034 RLSKQLNPFSPALRPIVSHNSDCAMSNDNNPQLFEFC---KSLIETYLAVLIHMESQRVKYDSIV 1095

  Fly    74 EWLLNHGAYINGQDYESG-SSPLHRALYYGSIDCAVLL-------------LRYGA--------- 115
            ..|.|.  .||.:|.:.. .|...:.:..|...||.::             ..|.|
  Fly  1096 NALSNF--RINYEDNQFAIESSRFKPISAGCAYCACVVDGTAYFWGSSGIPSYYSAQKSTEPPEP 1158

  Fly   116 -----SLELLDEDTRCPLQAICRKCDDDDLATDSQNDVLVWGSNKNYNLGIGNE-QNTNTPQAVD 174
                 ||:||   ::..||....||........:.|.:...|:|....||||.. |....|..|.
  Fly  1159 AHAVKSLDLL---SQLNLQVHAIKCGRQHTLILTNNGLYSLGNNNLCQLGIGRHMQMALQPMLVT 1220

  Fly   175 FFRKSNLWLEQVALGAYHSLFCDKKGHLYAVGHGKGGRLGIGLENSLPAPKRVKVSSKLSGDSIQ 239
            .....|:.:  :..|.||:. ....|.||..|.|..|:||.|...::..|:.|   |......|.
  Fly  1221 ALDGMNITM--LEAGQYHNA-AVADGKLYMWGWGIYGQLGQGSCENIATPQLV---SFFKFKKIL 1279

  Fly   240 CISVSRQHSLVL-----THQSL------VFACGLNTDHQLGVRDAAEQLTQFKEVVALRDKGASD 293
            .||:...|:|||     :|...      :|..|.|...|||..::....|:....|.|.....|
  Fly  1280 QISLGHAHTLVLCGAPNSHMEANHCGNELFVFGSNHFGQLGTGNSDHGDTKTNLPVRLEVGDCS- 1343

  Fly   294 LVRVIACDQHSIAYGSRCV------YVWG--------ANQGQFGINSN-----------TPSITV 333
             :|:|    |:..:.:..|      :.||        |||.:...|:.           ......
  Fly  1344 -LRLI----HTKFFTNLAVDEQDRLFTWGSSPQALRLANQIKRRANAKQKMEENQQRELLSKQLE 1403

  Fly   334 PTLIKLPAKTTIRFVE--ANNAATV-----------------IYNE-------EKI--------- 363
            .||:..|..:|...||  .:.||.|                 :.||       |.|
  Fly  1404 ATLLPAPIPSTSTLVEPTTSYAAVVAGSTPKSSVSDTKDCQDVQNEAAPSDATETIAPASAKAAP 1468

  Fly   364 ---------ITLCYADKTRYIKTPNYEDLKSISVMGGNLKNSTKGSAAALKLLMLTETNVVYLWY 419
                     :.:...|.|.:: ||:..|...::   |.:...:.|   .....:::.:..:|.|.
  Fly  1469 PPVPVASPPVLVPEPDPTEHL-TPHLVDTSEVA---GRILQISSG---LFHFCLISSSCTLYTWG 1526

  Fly   420 ENTQ-------QFYRCNFSPIRLHQIKKILY-KCNQ--VMVLSEDGCV------YRGKCNQIALP 468
            :|.:       :..|....|..:..|::.:| .|..  .:|::.|..|      ..|:|.:...|
  Fly  1527 KNLEHQLGTEDKDRRAVLKPSPIDSIERPMYVDCGSDFTLVMTTDHVVRAFGGNSNGQCGRDLGP 1591

  Fly   469 SSALQEKSRGSLDNWQDNDQNKTEISREHV---------IRIELQ--RVP---NIDRATYIFCDE 519
            |                     .|..|:.|         :|.|.|  .||   |:.|.. |..|:
  Fly  1592 S---------------------VERMRQRVVCLPATKRLVRFESQCVEVPVEINLPRPR-IRLDQ 1634

  Fly   520 GFSSFAVLQESHTKYFRKP-SLPRREH------SFKKLLHETSDCDAVHDVVFHVDGEKFAAHKF 577
            ....:..:...:..:|.:| ::...:|      ::|......:......|::..:  |..:.:..
  Fly  1635 DPVRYLKVMPPYQPHFLQPANISFDQHCSVGTPNYKSSTEHAATGQDSDDMLSSL--ENLSQNDA 1697

  Fly   578 IIYSRAPGLRDLIRCYLDKDIYLNFDHLTGKMFELILNHIYSSYWPTEDD-IDCIQQSLG---PA 638
            .....||.|.| ....||.|                       |.|.|.. :...:|::|   ||
  Fly  1698 SFSYNAPVLGD-AHSSLDMD-----------------------YTPEEQSYVPLPEQAVGSGMPA 1738

  Fly   639 NPQQ---------RTRT------CEMFLPHLEKFQLVELTKYVQSYVRDHQFPLPNARKLFNRLY 688
            |.:|         .|.|      .|..|.||..:  :....|.                 |:.||
  Fly  1739 NAEQLLGRDDDDGSTYTQSTEGMGESSLQHLRHY--IHYCLYA-----------------FHGLY 1784

  Fly   689 RSD--------HPELYDVRIVCKDGKVLGAHKCMLVAR-LEYFEMMFMHLWAERSSVTMEGVPAE 744
            ..|        |...|.:||            |||..| :|.|.:......:.:.::.:    .|
  Fly  1785 NPDKIGECARPHRNEYRIRI------------CMLNFRFVEAFRLCLQSCGSAQRTLKL----FE 1833

  Fly   745 YMEPVLDYLYSLDNEAFCKQGYL---ETFLYNMITICDQYFIESLQNVCESLILDKISIRKCGEM 806
            |        :|.|.      ||:   .|.|.::|.....:|:|                ||. :|
  Fly  1834 Y--------FSKDT------GYVPLRRTDLKHLIYHLCLHFLE----------------RKF-DM 1867

  Fly   807 LEFAAMYNCKILQKGCMDFICQNLSRVLCYRSIEQCDGETL-KCLNDHYRKMFKRVFDYRQITPF 870
            ||      |:....|.:|:....|:.|..:.:    :..|| :.||..::::.......:..|..
  Fly  1868 LE------CERFFMGDLDYYLLELAYVFYFNN----NNSTLEQNLNQKFKQLIAAADSNQAATSA 1922

  Fly   871 SEAIED--------------------ELLLSFVDGCD 887
            .:.:|.                    :.|||:.| ||
  Fly  1923 GQELEQLQDTDVIFDSFTVKFKTILCQRLLSYSD-CD 1958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8060	NP_611117.2	ANK	<46..138	CDD:238125	24/120 (20%)
		ANK repeat	56..87	CDD:293786	8/31 (26%)
		Ank_4	57..111	CDD:290365	13/68 (19%)
		ANK repeat	89..121	CDD:293786	9/59 (15%)
		Ank_2	95..>138	CDD:289560	13/69 (19%)
		RCC1	147..195	CDD:278826	13/48 (27%)
		RCC1	199..251	CDD:278826	17/51 (33%)
		BTB	547..>635	CDD:295341	14/88 (16%)
		BTB	684..795	CDD:279045	25/122 (20%)
		BTB	697..798	CDD:197585	19/104 (18%)
		SPOP_C_like	798..>834	CDD:269810	9/35 (26%)
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511	95/451 (21%)
		RCC1_2	1175..1200	CDD:290274	4/24 (17%)
		RCC1	1193..1240	CDD:278826	13/49 (27%)
		RCC1	1242..1291	CDD:278826	17/51 (33%)
		RCC1_2	1503..1532	CDD:290274	4/31 (13%)
		RCC1	1522..1568	CDD:278826	8/45 (18%)
		RCC1_2	1558..1584	CDD:290274	4/25 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900