Protein Alignment CG8060 and Als2

DIOPT Version :10

• Sequence 1: NP_611117.2
• Gene: CG8060 / 36824
• FlyBaseID: FBgn0034113
• Length: 1189
• Species: Drosophila melanogaster
• Sequence 2: NP_001013431.1
• Gene: Als2 / 363235
• RGDID: 1310372
• Length: 1651
• Species: Rattus norvegicus
• Alignment Length: 1156
• Identity: 200/1156 - (17%)
• Similarity: 346/1156 - (29%)
• Gaps: 460/1156 - (39%)

  Fly   185 QVALGAYHSLFCDKKGHLYAVGHGKGGRLGIGLENSLP--------APKRVKVSSKLSGDSIQCI 241
            |.|||..|.:...:.|.:|:.|             :||        .|....:.|.|.|..:..:
  Rat    45 QAALGVKHGVLLTEDGEVYSFG-------------TLPWKSEAAEICPSSPLLESALVGHHVVTV 96

  Fly   242 SVSRQHSLVLTHQSLVFACGLNTDHQLGVRDAAEQLTQFKEVVALRDKGASDLVRV----IAC-D 301
            :....||..:|...:|:..|.|...|..|  |.:|.......|::.|...|.|:.|    :|| :
  Rat    97 ATGSFHSGAVTESGVVYMWGENAAGQCAV--ANQQYVSEPSPVSISDSETSPLLAVRILQLACGE 159

  Fly   302 QHSIAYG-SRCVYVWGANQGQFGINSNTPSITVPTLIKLPAKTTIRFVEANNAATVIYNEEKIIT 365
            :|::|.. ||.::.||.. .|.|:.:.|..:|.|..::..|...:..|......::      .:.
  Rat   160 EHTLALSISREIWAWGTG-CQLGLITTTFPVTKPQKVEHLAGRVVLQVACGAFHSL------ALV 217

  Fly   366 LCYADKTRYIKTPNYEDLKSISVMGGNLKNSTKGSAAALKLLMLTETNVVYLWYENTQQFYRCNF 430
            .|...          :|||.:.                                      .|||
  Rat   218 QCLPP----------QDLKPVP--------------------------------------ERCN- 233

  Fly   431 SPIRLHQIKKILYKCNQVM----------VLSEDGCVYRGKCNQIALPSSALQEKSRGSLDNWQD 485
                         :|:|::          ::|:..|...|    :.|..|..::.:........:
  Rat   234 -------------QCSQLLITMTDKEDHVIISDSHCCPLG----VTLSESQAEKHASTVTSPHPE 281

  Fly   486 NDQNKTEISREHVIRIELQRVPNIDRAT---YIFCDEGFSSFAVLQESHTKYFRKPSLP------ 541
            ....:.|:....|...||..  ..|:.|   .|...:.....|.:..:.|    .||.|
  Rat   282 TLDGQGEVFENTVAEAELNM--GSDQTTSGSAISAQQNIVGMAEVSSART----APSYPDTQTVT 340

  Fly   542 -----RREHSFK-------KL-------------LHE--TSDCDAVHDVVF---HVDGEKFAA-- 574
                 ..|||.|       ||             ||.  |:...|::.:|.   ...|.:.||
  Rat   341 AYLQKLSEHSVKENHEREEKLPQVQPLVEEAVPDLHSPPTTSTSALNSLVVSCASAVGVRVAATY 405

  Fly   575 -------HKFI-IYSRAP---------------GLRDLIRCYLDKDIYLNFDHLTGKMFELILNH 616
                   .|.: .||.||               .|:||      ::..:..:.|.||....:::
  Rat   406 EAGALSLKKVMNFYSTAPCEPGAPSGTASTGPESLKDL------REEQVKQESLQGKKSSSLMD- 463

  Fly   617 IYSSYWPTEDDID------CIQQSLGPANPQQRTRTCEMFLPHLEKFQLVELTKYVQSYVRDHQF 675
                  ..|::.:      .:...|...:|:...:...:      |.:.|.||   .:|..:...
  Rat   464 ------IREEESEGGSRRLSLPGLLSQVSPRLLRKAARV------KTRTVVLT---PTYSGEADA 513

  Fly   676 PLPNARKLF--------NRLYRSD-HPELYDVRIVCKDGKVL------GAHKCMLVARLEYFEMM 725
            .||:.|...        .:|...| .|.|..:.:.|.|||.:      |:|...|.|:.:.:.
  Rat   514 LLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGSHSLALTAKSQVYS-- 576

  Fly   726 FMHLWAER-----------------SSVTME-GV------------------------------- 741
                |...                 |.|:.| ||
  Rat   577 ----WGSNTFGQLGHSEFPTTVPRLSKVSSESGVWSVAAGHGYSLFLVDTEDFQPGLYYSGRQDR 637

  Fly   742 ---------PAEYMEPVL-----------------DYLYSLDNEAFCKQGYLETFLYNMITICDQ 780
                     |:....|||                 .||..:|...   .||:.: |:.:.|...:
  Rat   638 AEGDTLPENPSGTTTPVLLSCSKLGYISRVTAGKDSYLALVDKNI---MGYIAS-LHELATTERR 698

  Fly   781 YF-------------------------IESLQNVC------------------------------ 790
            ::                         ::.||.|.
  Rat   699 FYSKLSEIKSQILRPLLSLEHLGTVTTVQLLQEVASRFSKLCYLIGQHGASLSSYLQGMKEARNL 763

  Fly   791 -----ESLILDKISIRKCGEMLEFAAMYNCKILQKGCMDFICQNLSRVLCYRSIEQCDGETLKCL 850
                 .||.||..: ..|..:..|..|...::|.|..:||:.:|...:.....:...:.:.::.|
  Rat   764 VIMKHSSLFLDSYT-EYCTSVSNFLVMGGSQLLAKPAIDFLNKNQELLQDLSEVNDENTQLMEIL 827

  Fly   851 NDHYRKMFKRVFDYRQITPFSEAIEDELLLSFVDGCDV---DLNYRMDAESKLKQAAKHKQKDLR 912
            |..:....:|:.:|.::           ||......:|   :.....|:.|..:..|.|..|  :
  Rat   828 NALFFLPIRRLHNYAKV-----------LLKLATCFEVTSPEYQKLQDSSSCYESLALHLGK--K 879

  Fly   913 KQDARHQYEQQAISSMMRSLSISESTQGTEVPSSPQDSARSEDKNWSRVVDKKDQKRKLAETA-- 975
            :::|.:            :||..::     .|....||.|            |.::|.|.|::
  Rat   880 RKEAEY------------TLSFWKT-----FPGKMTDSLR------------KPERRLLCESSNR 915

  Fly   976 ---------------LKVNNTLKHEDPPTQELVPIE---RKPLKEQTPPPPSHETEPTTPLSKSY 1022
                           :..|:.|.|....|..:.|:.   .:||.|:|  ...:..:.||| .:.:
  Rat   916 ALSLQHAGRFSVNWFILFNDALVHAQFSTHHVFPLATLWAEPLSEET--GGVNGLKITTP-EEQF 977

  Fly  1023 NLDFSSLTPQ---------SQKLSQKQRKRLSSESKSWRTNNPPLVEQSST 1064
            .|  .|.|||         ||.:.|..|          .|::.||...|||
  Rat   978 TL--ISSTPQEKTKWLRAISQAVDQALR----------GTSDFPLYGGSST 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8060	NP_611117.2	ANKYR	<51..141	CDD:440430
		ANK repeat	56..87	CDD:293786
		ANK repeat	89..121	CDD:293786
		ATS1	140..>355	CDD:444065	44/183 (24%)
		BTB_POZ	543..643	CDD:453885	28/155 (18%)
		BTB2_POZ_IBtk	691..802	CDD:349611	35/252 (14%)
		BACK_IBtk	798..857	CDD:350575	10/58 (17%)
Als2	NP_001013431.1	ATS1	<18..219	CDD:444065	44/195 (23%)
		RCC1 1	59..108		11/61 (18%)
		RCC1 2	109..167		16/59 (27%)
		RCC1 3	169..218		10/55 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	444..476		4/38 (11%)
		RCC1 4	519..570		12/50 (24%)
		ATS1	522..>622	CDD:444065	18/105 (17%)
		RCC1 5	572..621		6/54 (11%)
		RhoGEF	689..873	CDD:470622	26/195 (13%)
		PH_alsin	899..1004	CDD:241423	28/131 (21%)
		COG4642	<1012..1243	CDD:443680	3/5 (60%)
		MORN 1	1043..1065
		MORN 2	1066..1088
		MORN 3	1094..1116
		MORN 4	1117..1139
		MORN 5	1145..1167
		MORN 6	1169..1191
		MORN 7	1192..1214
		MORN 8	1215..1238
		VPS9	1546..1650	CDD:460489