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Protein Alignment CG8060 and herc1

DIOPT Version :9

Sequence 1:	NP_611117.2	Gene:	CG8060 / 36824	FlyBaseID:	FBgn0034113	Length:	1189	Species:	Drosophila melanogaster
Sequence 2:	XP_009301513.1	Gene:	herc1 / 336598	ZFINID:	ZDB-GENE-030131-8542	Length:	4867	Species:	Danio rerio

Alignment Length:	1384	Identity:	252/1384 - (18%)
Similarity:	439/1384 - (31%)	Gaps:	490/1384 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 LDEDTRCPLQAICRKCDD-------------DDLATDSQN-DVLVWGSNKNYNLGIGNEQNTNTP 170
            |.|...|..:.:||...|             .:.|..|:. :|.|||||.::.|..|.::....|
Zfish   327 LYEAALCLFEEVCRMASDYSRTCASPDSIQAGEAAMVSETCEVYVWGSNSSHQLVEGTQEKILQP 391

  Fly   171 QAVDFFRKSNLWLEQVALGAYHSLFCDKKGHLYAVGHGKGGRLGIGLENSLPAPKRV-------- 227
            :....|..:    :.:..|.|.:......|.:.|.|.|..||||:|..|:....|::
Zfish   392 KLAPSFSDA----QTIEAGQYCTFVISSDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRAI 452

  Fly   228 -KVSSKLSGDSIQCISVSRQHSLVLTHQSLVFACGLNTDHQLGVRDAAEQLTQFKEVVALRDKGA 291
             ||||....|.         |:|..|.:..||:.|.....:||..:::.|  ::.:::....:|
Zfish   453 KKVSSSKGSDG---------HTLAFTSEGEVFSWGDGDYGKLGHGNSSTQ--KYPKLIQGPLQG- 505

  Fly   292 SDLVRVIAC----DQHSIAYGSRC-VYVWGANQGQFGI--NSNTPSITVPTLIKLPAKTTIRFVE 349
                :|:.|    .:||.|..... :|.||  :|.||.  :.::.|..:|||:|          :
Zfish   506 ----KVVVCVSAGYRHSAAVSEDGELYTWG--EGDFGRLGHGDSNSRNIPTLVK----------D 554

  Fly   350 ANNAATVIYNEEKIITLC------------------YADKTRYIKTPNYEDLKSISVMGGNLKNS 396
            .:|...|.......|.|.                  :.|..|..|....|.|:.:.:
Zfish   555 ISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVVEALQGMFI-------- 611

  Fly   397 TKGSAAALKLLMLTETNVVYLWYENTQQFYRCNFS-----------PIRLHQIKKILYKCNQVMV 450
            .|..|.:...|.||.|..||.|  .......|..|           .:...::..|....:..:.
Zfish   612 RKVCAGSQSSLALTSTGQVYAW--GCGACLGCGSSEATALRPKLIEELATTRVVDISIGDSHCLA 674

  Fly   451 LSEDGCVY------RGKCNQ-------------IALPSSALQEKSRGSLDN--WQ--DNDQNKTE 492
            ||.|..||      .|:|.|             |.|...|:|:.|.|:..:  |.  ..|:....
Zfish   675 LSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVIGLDGVAIQQISAGTSHSLAWTALPRDRQVVA 739

  Fly   493 ISREHVIRIELQRVPNIDRATYIFCDEGFSS------FAVLQESH-------------------- 531
            ..|.:.:.:|.....::......:|| |.::      |...:|.|
Zfish   740 WHRPYCVDLEESTFSHLRSFLERYCD-GINNEIPPLPFPSSKEHHNFLKLCLRLLSNHLALALAG 803

  Fly   532 ---TKYFRKPSLPRREHSFKKLLHETSDCDAVHDVVFHVDGEKFAAHKFIIYSRAPGLR---DLI 590
               |....:.:.|.|...|:  |.:.|..|.:.:.|.    |..:....::   .|.||   :|:
Zfish   804 GVATSILGRQARPLRNLLFR--LMDASVPDEIQEAVI----ETLSVGATML---LPPLRERMELL 859

  Fly   591 RCYLDK----------------DIYLNF------------------------------------- 602
            ...|.:                ||.|..
Zfish   860 HSLLPQGPDRWESLSKGQRMQLDIILTSLQDHTHVASLLGYSCPPDASEPPAQPSDSTHVPGTHS 924

  Fly   603 -----DHLTGKMFELILNHI--YS--SYWPTEDDIDCIQQSLGPANPQQRTRTCEMFLPHLEKFQ 658
                 .||...:.:.:|.::  |:  ::...|.:.|.|.|....::..|..        ||.:.
Zfish   925 DTHPDTHLAEILMKTLLRNLGFYTDQAFGELEKNSDKILQGTSSSDSSQPA--------HLHEL- 980

  Fly   659 LVELTKYVQSY---------------VRDH-QFPLPNARKLFNR---LYR------SDHPELYDV 698
            |..|.|.:.:|               :..| |..||:|..:|||   |.|      |...:|.||
Zfish   981 LCSLQKQLLAYCHINSVTEGSSSVALLHKHLQLLLPHATDIFNRSATLLRESSGNGSVREKLRDV 1045

  Fly   699 RIVCKDGKVLGAHKCMLVARLEYFEMMFMHLWAER----------------SSVTMEGVPAEYME 747
            ..:...|.:|    |.:|..|     :.:.:|..|                :.:.....|.|..|
Zfish  1046 IYMSAAGSML----CQIVTSL-----LLLPVWVARPLLSFLLDLLPPLDRLNKLLPAATPLEEQE 1101

  Fly   748 -------------------PVLDYLYSLDNE-------AFCKQG----------------YLETF 770
                               |...:::.:|.|       ..|..|                :|:|.
Zfish  1102 LQWPLHGSPDLVDPVCVSGPAQSWVWLVDLERTAALLVGRCLGGMLQGAAPSAEEQHTTHWLKTP 1166

  Fly   771 LYN--------MITICDQYFIESLQNV------------CE-----SLILDKISIRKCGE----- 805
            |::        .:..|    |.||..|            |:     |:::| :::....|
Zfish  1167 LFSNGLETEIPQLDAC----ISSLLEVALCGNEEQRPFDCQLRADMSVLVD-LALGSTKEPTHSL 1226

  Fly   806 ---MLEFAAMY---NCKILQKGCMDFICQNLSRVLCYRS--IEQCDGE----TLKCLNDHYRKMF 858
               |.::|...   :..:..:..:|.:.:.:..||...:  :.|..||    ..|.|.:.||.::
Zfish  1227 WSNMQDYAISKDWDSASLPNEALLDTVSRFVLAVLLKHTGLLGQACGEGRYQPCKLLAEVYRSVY 1291

  Fly   859 K---RVFDYR--QITPFSEAIEDELLLSFVDGCDVD-----LNYRMDAESKLKQAAKHKQKDLRK 913
            |   |:...:  ::.....:..:..:...||..::|     ....:|.|::|::..:.::::...
Zfish  1292 KVRNRLLACKNMELIQTRSSSRERRISDNVDSVEMDPQEHSFTRTIDEEAELEERDREREREEGH 1356

  Fly   914 QDARHQYEQQAISSMMRS------LSISESTQGTEVPSSPQDSARSEDKNWSRVVDKKDQKRKLA 972
            |:...:.|::....|...      ||..|:.:|           |..|:..|..|
Zfish  1357 QEQEDEEEEREHEVMTAGKIFQCFLSAREAARG-----------RDRDRTGSMSV---------- 1400

  Fly   973 ETALKVNNTLKHEDPPTQELVPIERKPLKEQTPPPPSHETEPTT--------------------- 1016
                       .|:||       :..|.:..:..|...:...||
Zfish  1401 -----------QEEPP-------QPGPERRNSSTPQEGQDLYTTSCNAVIHRCAMLLLALSTPLA 1447

  Fly  1017 ------PLSKSYNLDFSSLTPQSQKLSQKQRKRLSSES----KSWRTNNPPLVEQSSTPVAVPNA 1071
                  ||:...|.|......:|:.||.:.|...||.|    ||          :|.:.::.|.
Zfish  1448 QHINQQPLTGGVNQDGVGFMTRSESLSAESRSIHSSPSCRLTKS----------RSESDLSQPE- 1501

  Fly  1072 WGVTTTPSGSFNDSFTSPTTGSSTDPTSFANMMRGHATSSTTPTDQSQSFSRILADE--KRQRES 1134
                     |..:.::.....:.....:|....||...||  |...:..|...||.|  ...::|
Zfish  1502 ---------SDEEGYSLNARRNVDLDLAFTPKKRGFLYSS--PDSSADWFGGRLARECFYSSQQS 1555

  Fly  1135 YERM---RNKSL-VHTQIE 1149
            |:..   .|:|| :|..||
Zfish  1556 YDESDLDLNQSLRLHALIE 1574

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.