DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8060 and Herc2

DIOPT Version :9

Sequence 1:	NP_611117.2	Gene:	CG8060 / 36824	FlyBaseID:	FBgn0034113	Length:	1189	Species:	Drosophila melanogaster
Sequence 2:	XP_006229362.1	Gene:	Herc2 / 308669	RGDID:	1307989	Length:	4836	Species:	Rattus norvegicus

Alignment Length:	969	Identity:	176/969 - (18%)
Similarity:	299/969 - (30%)	Gaps:	348/969 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 LATDSQNDVLVWGSNKNYNLGIGNEQNTNTPQAVDFFRKSNLWLEQVALGAYHSLFCDKKGHLYA 204
            ||..|:.:|..||..::..||.||....:.|:.::..|  .:.:..||.|..||......|.||.
  Rat  4054 LALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLR--GIEVVDVAAGGAHSACVTAAGDLYT 4116

  Fly   205 VGHGKGGRLGIGLENSLPAPKRV------------------------------------------ 227
            .|.|:.||||.........||.|
  Rat  4117 WGKGRYGRLGHSDSEDQLKPKLVEALQGHRVIDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGR 4181

  Fly   228 ------KVSSK---LSGDSIQCISVSRQHSLVLTHQSLVFACGLNTDHQLGVRDAAEQLTQFKEV 283
                  ||..|   |:|..:..:....|.|:.||....|:..|....|:|| ..:.:.:.:.::|
  Rat  4182 GGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLG-HGSDDHVRRPRQV 4245

  Fly   284 VALRDKGASDLVRVIACDQHSIAYGS-RC--------VYVWGAN-QGQFGINSNTPSITVPTLIK 338
            ..|:.|      :|||     ||.|| .|        ||.||.| :||.| :..|.:|..|.|:.
  Rat  4246 QGLQGK------KVIA-----IATGSLHCVCCTEDGEVYTWGDNDEGQLG-DGTTNAIQRPRLVA 4298

  Fly   339 LPAKTTIRFVEANNAATVIYNEEKIITLCYADKTRYIKTPNYEDLKSISVMGGNLKNSTKGSAAA 403
            ......:..|...:|.|:.::..|..:   |.|........|..|:.|.::.  |:|
  Rat  4299 ALQGKKVNRVACGSAHTLAWSTSKPAS---AGKLPAQVPMEYNHLQEIPIIA--LRN-------- 4350

  Fly   404 LKLLMLTETNVVYLWYENTQQFYRCNFSPIRLHQIKKILYKCNQVMVLSEDGCVYRGKCNQIALP 468
             :||:                          ||.|.::...|..:..|       .|..::..|.
  Rat  4351 -RLLL--------------------------LHHISELFCPCIPMFDL-------EGSLDETGLG 4381

  Fly   469 SSALQEKSRGSLDNWQDNDQNKTEI-------SREHVIRIELQRV-------------PNIDRAT 513
            .|...:..||.|.: |..:....::       .|:|...:||.|:             |:..::.
  Rat  4382 PSVGFDTLRGILIS-QGKEAAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSKGGLAGPDGTKSV 4445

  Fly   514 YIFCDEGFSSFAVLQESHTKYFRKPS---LPRREHSFKKLLHETSDC-----DAVHDV------- 563
            :.......|||:            |.   ||.|....|.:.....||     :::.::
  Rat  4446 FGQMCAKMSSFS------------PDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNG 4498

  Fly   564 -----VFHVDGEKFAAHKFIIYSRAPGLRDLIRCYLDK--DIYLNFDHLTGKMFELILNHIYSSY 621
                 :...:|...:......|...|..|..:.|.:.:  .:.|.....||....|   ::....
  Rat  4499 LTPLLIVTPNGRDESGANRDCYLLNPATRAPVHCSMFRFLGVLLGIAIRTGSPLSL---NLAEPV 4560

  Fly   622 WP-------TEDDIDCIQQSLGPANPQQRTRTCEMFLPHLEKFQLVELTKYVQSYVRDHQFPLPN 679
            |.       |..|:..:.:.               |:|.|             .|:||::
  Rat  4561 WKQLAGMSLTIADLSEVDKD---------------FIPGL-------------MYIRDNE----- 4592

  Fly   680 ARKLFNRLYRSDHPELYDVRIVCKDGKVLGAHKCMLVARLEYFEMMFM------------HLWAE 732
                                                 |..|.||.|.:            .|.::
  Rat  4593 -------------------------------------ATSEEFEAMSLPFTVPSASGQDIQLSSK 4620

  Fly   733 RSSVTMEGVPAEYMEPVLDY-LYSLDNE-AFCKQGYLETFLYNMITICDQYFIESLQNVCESLIL 795
            .:.:|::. .|||:...::| |:..|.: |..::|........::::...|.:|::  ||
  Rat  4621 HTHITLDN-RAEYVRLAINYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETM--VC----- 4677

  Fly   796 DKISIRKCGEMLEFAAMYNCKILQKGCMDFICQNLSRVLCYRSIE------QCDGETLKCLNDHY 854
                                     |..|.....|..|..|:.||      |...|.::..::..
  Rat  4678 -------------------------GSPDIPLHLLKSVATYKGIEPSASLVQWFWEVMESFSNTE 4717

  Fly   855 RKMFKR-----------VFDYR----------QITPFSEAIEDELLLSFV-----DGCDVDLNYR 893
            |.:|.|           :.|:|          :..|....:.:.....|:     ..|      :
  Rat  4718 RSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSC------K 4776

  Fly   894 MDAESKLKQAAKHKQKDLRKQDARHQYEQQAISSMMRSLSISESTQGTEVPSSPQDSAR 952
            ...|.|||.|. |..|.:...|    |.:.|::....:...||.:...:..|...||.:
  Rat  4777 QVLEEKLKYAI-HFCKSIDTDD----YARIALTGEPAADDSSEDSDNEDADSFASDSTQ 4830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8060	NP_611117.2	ANK	<46..138	CDD:238125
		ANK repeat	56..87	CDD:293786
		Ank_4	57..111	CDD:290365
		ANK repeat	89..121	CDD:293786
		Ank_2	95..>138	CDD:289560
		RCC1	147..195	CDD:278826	14/47 (30%)
		RCC1	199..251	CDD:278826	19/102 (19%)
		BTB	547..>635	CDD:295341	15/113 (13%)
		BTB	684..795	CDD:279045	19/124 (15%)
		BTB	697..798	CDD:197585	19/114 (17%)
		SPOP_C_like	798..>834	CDD:269810	3/35 (9%)
Herc2	XP_006229362.1	ATS1	<494..787	CDD:227511
		Cyt-b5	1212..1283	CDD:395121
		MIB_HERC2	1871..1931	CDD:399589
		UBA_HERC2	2461..2508	CDD:270585
		Cul7	2555..2632	CDD:402903
		SH3_15	2640..2697	CDD:408152
		ZZ_HERC2	2707..2751	CDD:239084
		APC10-HERC2	2766..2911	CDD:176485
		ATS1	2957..3323	CDD:227511
		ATS1	4025..4330	CDD:227511	72/293 (25%)
		HECTc	4423..4794	CDD:238033	73/495 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900