DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8060 and Rcbtb2

DIOPT Version :9

Sequence 1:	NP_611117.2	Gene:	CG8060 / 36824	FlyBaseID:	FBgn0034113	Length:	1189	Species:	Drosophila melanogaster
Sequence 2:	XP_038949091.1	Gene:	Rcbtb2 / 290363	RGDID:	735048	Length:	585	Species:	Rattus norvegicus

Alignment Length:	766	Identity:	150/766 - (19%)
Similarity:	248/766 - (32%)	Gaps:	281/766 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 ASLELLDEDTRCPLQAICRK--------------CDDDDLATDSQNDVLVWGSNKNYNLGIGNEQ 165
            :||::||.. :.|:.::|.:              ..::.|.|...:::.|.|:|.:..||:|:.|
  Rat    55 SSLKMLDVG-KWPIFSLCSEEELQLIRQACVFGTAGNEVLYTTVNDEIFVLGTNCSGCLGVGDIQ 118

  Fly   166 NTNTPQAVDFFRKSNLWLEQVALGAY----HSLFCDKKGHLYAVGHGKGGRLGIGLENSLPAPKR 226
            :|..|:.:|     :|..:::|..:|    |.:.....|.::..||....:||.|..|....|
  Rat   119 STIEPRRLD-----SLTGKKIASLSYGSGPHIVLATTDGEVFTWGHNAYSQLGNGTTNHGLVP-- 176

  Fly   227 VKVSSKLSGDSIQCISVSRQHSLVLTHQSLVFACGLNTDHQLGVRDAAEQLTQFKEVVALRDKGA 291
            ..:|:.||...:..::....||||||....|||.|.|...|:|....|.|....:....|::|
  Rat   177 CHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNK-- 239

  Fly   292 SDLVRVIACDQHSIAYGSRC---------VYVWGAN-QGQFGINSNTPSITVPTLIKLPAKTTIR 346
              :|..|||       |..|         |||||.| .||.|:.|   |...||..::.|...||
  Rat   240 --VVMSIAC-------GQMCSMAVVDTGEVYVWGYNGNGQLGLGS---SGNQPTPCRVAALQGIR 292

  Fly   347 FVEANNAATVIYNEEKIITLCYADKTRYIKTPNYEDLKSISVMGGNLKNSTKGSAAALKLLMLTE 411
            .              :.:...||                                   ..|:||:
  Rat   293 V--------------QRVACGYA-----------------------------------HTLVLTD 308

  Fly   412 TNVVYLWYENTQQFYRCNFSPIRLHQIKKILYKCNQVMVLSEDGCVYRGKCNQIALPSSALQEKS 476
            ...:|.|..|:.                               |.:..|..:..:.|:..:.||.
  Rat   309 EGQIYAWGANSY-------------------------------GQLGTGNKSNQSYPTPVVVEKD 342

  Fly   477 RGSLDNWQDNDQNKTEISREHVIRIELQRVPNIDRATYIFCDEGFSSFAVLQESHTKYFRKPSLP 541
            |                    :|.|..             |....:|.|..|..|
  Rat   343 R--------------------IIEIAA-------------CHSAHTSAAKSQGGH---------- 364

  Fly   542 RREHSFKKLLHETSDCDAVHDVVFHVDGEKFAAHKFIIYSRAPGLRDLIRCYLDKDIYLNFDHLT 606
                                                                    :|: :....
  Rat   365 --------------------------------------------------------VYM-WGQCR 372

  Fly   607 GKMFELILNHIYSSYWPTEDDIDCIQQSLGPANPQQRTRTCEMFLPHLEKFQLVELTKYVQSYVR 671
            |:  .:||.|: :.:..|:|...|.      |.|....|...           ||        ..
  Rat   373 GQ--SVILPHL-THFCCTDDVFACF------ATPAVTWRLLS-----------VE--------PD 409

  Fly   672 DHQFPLPNARKLFNRLYRSDHPELYDVRIVCKDGKVLGAHKCMLVARLEYFEMMFMHLWAERSSV 736
            ||.....:.::.|      |:|:..|::.:. |||.:.|||.:|..|.|:|......  :|...|
  Rat   410 DHLTVAESLKREF------DNPDTADLKFLV-DGKYIYAHKVLLKIRCEHFRSSLED--SEDDIV 465

  Fly   737 TMEGVPAEYMEPV----LDYLYSLDNEAFCKQGYLETFLYNMITICDQYFIESLQNVCESLILDK 797
            .|    :|:..||    |:|||: ||.:...:..:     .::.:...|....|:.:|:..|...
  Rat   466 EM----SEFSYPVFRAFLEYLYT-DNISLPPEEAV-----GLLDLATFYSETRLKKLCQQTIKQG 520

  Fly   798 ISIRKCGEMLEFAAMYNCKILQKGCMDFICQNLSRVLCYRSIEQCDGETLK 848
            |.......:|..|..|:.:.|::.|..|...:|:.|.......:.|.:.||
  Rat   521 ICEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLK 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8060	NP_611117.2	ANK	<46..138	CDD:238125	6/36 (17%)
		ANK repeat	56..87	CDD:293786
		Ank_4	57..111	CDD:290365
		ANK repeat	89..121	CDD:293786	2/5 (40%)
		Ank_2	95..>138	CDD:289560	6/36 (17%)
		RCC1	147..195	CDD:278826	14/51 (27%)
		RCC1	199..251	CDD:278826	14/51 (27%)
		BTB	547..>635	CDD:295341	8/87 (9%)
		BTB	684..795	CDD:279045	29/114 (25%)
		BTB	697..798	CDD:197585	27/104 (26%)
		SPOP_C_like	798..>834	CDD:269810	8/35 (23%)
Rcbtb2	XP_038949091.1	ATS1	<141..421	CDD:227511	87/503 (17%)
		BTB_POZ_RCBTB2_CHC1L	408..524	CDD:349663	33/134 (25%)
		BACK_RCBTB2	521..585	CDD:350604	12/51 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900