DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8060 and Zzef1

DIOPT Version :9

Sequence 1:	NP_611117.2	Gene:	CG8060 / 36824	FlyBaseID:	FBgn0034113	Length:	1189	Species:	Drosophila melanogaster
Sequence 2:	XP_006246919.1	Gene:	Zzef1 / 287476	RGDID:	1311189	Length:	2965	Species:	Rattus norvegicus

Alignment Length:	912	Identity:	162/912 - (17%)
Similarity:	291/912 - (31%)	Gaps:	307/912 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   384 KSISVMGGNLKNSTKGSAAALKLLMLTETNVVYL---WYENTQQFYRCNFSPIRLHQIKKILY-- 443
            |:..|.|..:..:...:.|||          ||.   .||..|::         :|...||..
  Rat  1324 KTDIVAGSTIDQAVNATFAAL----------VYRTPDLYEKLQKY---------VHSGGKIALPE 1369

  Fly   444 KCNQVMVLSEDGCVYRGKCNQIALPSSALQEKSRGSLDNWQDNDQN-----------------KT 491
            :.:||..|::...::..:..|.:|.|.....:.:..|:..:.|.:|                 .:
  Rat  1370 EFSQVYSLADGIRIWMLEMKQKSLVSMGNDSEEKRGLETAEVNPENLAKECIQKSLLLLKFLPMS 1434

  Fly   492 EISREHVIRI----ELQRVPNIDR--ATYIFCDEGFSSFAVLQESHT------------------ 532
            :.|:|:..::    |..|:..:||  .|....:|.|...|...|:.|
  Rat  1435 KSSKENCDKLVPVDETDRLQPLDRRQRTSSVVEEHFQGSASPTEAATPAADDKSPGLEMQPKLLP 1499

  Fly   533 ------------KYFRKPSLPRREHSFK---------KLLHETSDCDAV-------HDVVFHVDG 569
                        :....||.|.|...|.         :.:.||.....|       .||:..:..
  Rat  1500 SSGPSAAEVSTAEEPSSPSTPTRRPPFTRGRLRLLSFRSMEETRPVPTVKEKYPVLKDVMDFIKD 1564

  Fly   570 EKFAAHKFII------YSRAPGLRDLIR-------------CY-------------LDKDIYLNF 602
            :.. :|:.|:      .::|..:.:::|             |:             ..||....|
  Rat  1565 QSL-SHESIVKVLSLRKAQAQSILEVLRIIQYCTESLGQPHCFHPPYILFLLELLTCQKDFTNYF 1628

  Fly   603 DHLTG-----------KMFELILNHIYS----------SYWPTEDDIDCIQQSLGPA-----NPQ 641
            .||.|           ..::|:|..:.:          |..|.   :.|:|.:|...     .|.
  Rat  1629 GHLEGCGADLHKEIRDTYYQLVLFLVKAIKGFSSINDRSLLPA---VSCVQTALLHLLDMGWEPS 1690

  Fly   642 QRTRTCEMFLPHLEKFQLVELTKYVQSYVRDHQFPLPNARKLFNRLYRSDHPELYDVR------I 700
            ......::.||.|       |....|..:..|...:..         .|:..||.|.:      .
  Rat  1691 DLAFFVDIQLPDL-------LMNMSQENISIHDSVISQ---------WSEEDELADAKQNSEWMD 1739

  Fly   701 VCKDGKVLGAHKCMLVARLEYFEMMFMHLWAER------SSVTMEGVPAEYMEPVLDY--LYSLD 757
            .|:||.....::  .:|:.:..:...||::..|      ..::.:|  .:.:.|...|  |...|
  Rat  1740 ECQDGMFEAWYE--KIAQEDPEKQRKMHMFIARYCDLLNVDISCDG--CDEIAPWHRYRCLQCSD 1800

  Fly   758 NEAFCKQGYL----------ETFLYNMITICDQYFIESLQNVCESLILDKISIRKCGEMLEFAAM 812
            .: .||..:|          :..:.||...||.         |:.||:.:              .
  Rat  1801 MD-LCKTCFLGGVKPEGHGDDHEMVNMEFTCDH---------CQGLIIGR--------------R 1841

  Fly   813 YNCKILQKGCMDF-ICQNLSRVLCYRSIEQCDGE------------TLKCLNDHYRKMFKRVFDY 864
            .||.:    |.|| :|..     ||.:.:...|.            |:: ::|..|.:...:.:|
  Rat  1842 MNCNV----CDDFDLCYG-----CYAAKKYSYGHLPTHSITAHPMVTIR-ISDRQRFIQPYIHNY 1896

  Fly   865 RQITPFSEAIEDELLLS--FVDGCDVDLNYRMDAESKLKQAAK---------HKQKDLRK----- 913
            ..:...:.|:....|.|  .|||..:|...|..|.:...|..:         |:.|.|:.
  Rat  1897 SWLLFAALALYSAHLTSTEHVDGEQLDPQARGSAATLRSQCMQLVGDCLMKAHQGKGLKALALLG 1961

  Fly   914 --QDARHQYEQQAISSMMRSLSISESTQGTEVPSS-----PQDSARSEDKNWSRVVDKK------ 965
              .|.....|.||:..   ::||..|.:..|..::     |.|:......|..|..||:
  Rat  1962 VLPDGDSTSENQALPV---TVSIQASEEQLEKKTAQPAEGPADAGLFVPCNGKRATDKEVGPLDC 2023

  Fly   966 DQKRKLAETALKVNNTLKHEDPPTQELVPIERKPLKEQTPPPPSHETEPTTPLSKSYNLDFSSLT 1030
            .||:|..|. |.:     .:||..|  :.:...|..:..||.......|          |.||..
  Rat  2024 KQKKKAGED-LSI-----MKDPSCQ--IQVSDPPASDHVPPGLPDAEHP----------DRSSQA 2070

  Fly  1031 PQSQKLSQKQRKRLSSESKSWRTNN------PPLVEQSSTPV-----AVPNAWGVTTTPSGSFND 1084
            |..:|......:::.:|....|...      ||:....:.|:     .:|..:.|..:.:|..|:
  Rat  2071 PMEEKAITPSPEQVFAECSQKRILGLLAAMLPPIKSGPTVPLIDLEHVLPLMFQVVISNAGHLNE 2135

  Fly  1085 SF 1086
            ::
  Rat  2136 TY 2137

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8060	NP_611117.2	ANK	<46..138	CDD:238125
		ANK repeat	56..87	CDD:293786
		Ank_4	57..111	CDD:290365
		ANK repeat	89..121	CDD:293786
		Ank_2	95..>138	CDD:289560
		RCC1	147..195	CDD:278826
		RCC1	199..251	CDD:278826
		BTB	547..>635	CDD:295341	23/156 (15%)
		BTB	684..795	CDD:279045	25/134 (19%)
		BTB	697..798	CDD:197585	23/124 (19%)
		SPOP_C_like	798..>834	CDD:269810	6/36 (17%)
Zzef1	XP_006246919.1	EFh	<94..141	CDD:238008
		APC10-ZZEF1	250..380	CDD:176488
		CUB	<1119..1189	CDD:294042
		ZZ_EF	1779..1826	CDD:239083	8/49 (16%)
		ZZ	1828..1875	CDD:239069	14/78 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900