DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8060 and CG33288

DIOPT Version :9

Sequence 1:	NP_611117.2	Gene:	CG8060 / 36824	FlyBaseID:	FBgn0034113	Length:	1189	Species:	Drosophila melanogaster
Sequence 2:	NP_996136.2	Gene:	CG33288 / 2768968	FlyBaseID:	FBgn0053288	Length:	1115	Species:	Drosophila melanogaster

Alignment Length:	915	Identity:	170/915 - (18%)
Similarity:	282/915 - (30%)	Gaps:	339/915 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   420 ENTQQFYRCNFSPIRLHQIKKILYKCNQVMVLSEDGCVY---RGKCNQIAL--PSSALQEKSRGS 479
            ||||.::.....|     :|:::...||..|:.|.|.::   .....|:.:  ...|..:|..||
  Fly    19 ENTQSYFYIKNDP-----VKRLISGPNQSAVICESGRLFVWGENHYGQLGIGGHGGASGKKGGGS 78

  Fly   480 LDNWQDNDQNKTEISREHVIRIELQRVPNIDRATYIFCDEGFSSF--AVLQESHTKYFRKPSL-P 541
            .:...|.....|.:.....:.:::             ||..|.:.  .:|..|:..:|...:: |
  Fly    79 HNGNGDIVTKPTCVKALKTLGLKI-------------CDVAFGNHWAVMLTHSNEIFFTGRNIFP 130

  Fly   542 RREHSFKKLLHETSDCDAVHDVVFHVDGEKFAAHKFIIYSRAPGLRDLIRCYLDKD--------I 598
            ...|.            |.|.....||.:..|    ||  |.|...:....||.|:        :
  Fly   131 EDTHV------------AQHFTSAQVDQQPCA----II--RKPFRLEEFDDYLSKNEETDNFMTV 177

  Fly   599 YLNFDHL-----TGKMF------ELILNHIYSSY--WPTEDDIDC-IQQ-SLGPANPQQRTRTCE 648
            ....:|.     ||::.      :|.|..:.:.|  .|.|..:|. :|| :.||.:....|.|..
  Fly   178 QAGKEHFAVLTTTGRLIGCGSNAQLQLGELEADYDGHPVEIRLDAPVQQFTCGPESTLVLTATGN 242

  Fly   649 MFLP-HLEKFQLVELTKYVQSYVRDHQFPLPNARKLFNRLYRSDHPELYDVRIVCKDGKVLGAHK 712
            :||. ||.:|.....|:.        |..||....:
  Fly   243 LFLTGHLNEFVFPRFTEL--------QKNLPPTEAI----------------------------- 270

  Fly   713 CMLVARLEYFEMMFMHLWAERSSVTMEGVPAEYMEPVLDYLYSLDNEAFCKQGYLETFLYNMITI 777
                        :|||:     |.|.|             :|.:.|.....:.:
  Fly   271 ------------IFMHI-----SKTSE-------------VYIVTNAGSIYRSF----------- 294

  Fly   778 CDQYFIESLQNVCESLILDKISIRKCGE------MLEFAAMYNCKILQKGCMDFICQNLSRVLCY 836
                  |||:|  :||:..:.....|.|      :|:..:.|  .:|.|....|
  Fly   295 ------ESLRN--KSLVFQRFYDYDCEENGPIWKLLKGFSFY--AVLSKANKFF----------- 338

  Fly   837 RSIEQCDGETLKCLNDHYRKMFKRVFDYRQITPFSEAIEDELLL-----------SFVDGCDVDL 890
                     |....:.|:.|.|:.:..::.:.....|:.|:.:|           :.|:|.....
  Fly   339 ---------TTFSESGHHLKTFREISKFKNLRLLDIAVGDQHVLVQGIPRSSMSSASVNGSAEPN 394

  Fly   891 NY--------RMDAESKLKQAAKHKQKDLRKQDARHQYEQQAISSMMRSLSISESTQGT------ 941
            .|        ..||....:....|..:.|.||:...:.|..::|:.:..|:.:... ||
  Fly   395 RYVNRSFVLQPTDANGNKEDTRTHSGRSLIKQEGMEETEDLSMSTTVGELAAAAGA-GTAAAMEA 458

  Fly   942 -------EVPSSPQDSARSEDKNW------------------------SRVVDKK---------- 965
                   |.|....|..|.:|.|.                        |.:.:|:
  Fly   459 VKHLINGEKPEEKSDLTRYQDLNANIESADIIPKEHKEAKGSDEIGPNSNISEKEEDNQIADRVT 523

  Fly   966 ---------DQKRKL-------AETALKVNNTLKHEDP-----------PTQE--LVPI------ 995
                     ||::.:       ...|:|.|:..|...|           .|:|  |.||
  Fly   524 PGNKNESAADQEKSVHSPNTAATSEAIKTNDGYKEMKPSATIESPVITADTKESSLKPIVSPVKT 588

  Fly   996 ERKPLK-------------------EQTPPPPSHETEPTTPLSKSYNLDFSSLTPQSQKLSQKQR 1041
            :|.|.|                   ::.|.||:|  .||.|.|.:.:|. |:.:....:|...:.
  Fly   589 KRSPAKTIESSIKSSSSPVKPTESMQKLPTPPTH--TPTPPNSPTESLR-SNKSAHDMELVDPKP 650

  Fly  1042 KRLSSESKSWRTNNP-PLVEQSSTPVAVPNAWGVTTTPSGSF-------NDSF--TSPTTGSSTD 1096
            |...|:....|...| |....||||..:..      ||..:|       :|..  |||...||.|
  Fly   651 KVPGSQETLLRPRTPYPESSNSSTPQTIKK------TPIRNFSYESAMDHDHLERTSPELVSSLD 709

  Fly  1097 PTSFANMMRGHATSSTTPTDQSQSFSRILADEKRQRESYERMRNKSLVHTQIEERAIAELREFYN 1161
            ........:.|..:.|.||:..:..:..:...|...:|               .:.|.|:| |.|
  Fly   710 TVEEVPTAKIHVNTPTPPTEDDEHLAVEITTTKDSTDS---------------SKVINEIR-FIN 758

  Fly  1162 VDNID 1166
             |.:|
  Fly   759 -DGVD 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8060	NP_611117.2	ANK	<46..138	CDD:238125
		ANK repeat	56..87	CDD:293786
		Ank_4	57..111	CDD:290365
		ANK repeat	89..121	CDD:293786
		Ank_2	95..>138	CDD:289560
		RCC1	147..195	CDD:278826
		RCC1	199..251	CDD:278826
		BTB	547..>635	CDD:295341	23/110 (21%)
		BTB	684..795	CDD:279045	14/110 (13%)
		BTB	697..798	CDD:197585	14/100 (14%)
		SPOP_C_like	798..>834	CDD:269810	7/41 (17%)
CG33288	NP_996136.2	ATS1	5..>260	CDD:227511	59/276 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900