DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8060 and IBTK

DIOPT Version :9

Sequence 1:	NP_611117.2	Gene:	CG8060 / 36824	FlyBaseID:	FBgn0034113	Length:	1189	Species:	Drosophila melanogaster
Sequence 2:	XP_006715516.1	Gene:	IBTK / 25998	HGNCID:	17853	Length:	1394	Species:	Homo sapiens

Alignment Length:	1415	Identity:	366/1415 - (25%)
Similarity:	591/1415 - (41%)	Gaps:	293/1415 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DCTAKCRLRQHGNAITAALTKRSIDNQKLASFIFKTCGNFANILDDLGRSAVHMSASTARYEILE 74
            |||:|||..:|...:.:.:||.| :|| :.:|:...|.|.|.|.|..||:|:|:.:|..:..:|:
Human     7 DCTSKCRSLKHALDVLSVVTKGS-ENQ-IKAFLSSHCYNAATIKDVFGRNALHLVSSCGKKGVLD 69

  Fly    75 WLLNHGAYINGQDYESGSSPLHRALYYGSIDCAVLLLRYGASLELLDEDTRCPLQAICRKCDDDD 139
            ||:..|..:..:|.|||.:.|||:::||.|||...||::|.||.:.|::....|..:.:     |
Human    70 WLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGLSALDLVMK-----D 129

  Fly   140 LAT------DSQNDVLVWGSNKNYNLGIGNEQNTNTPQAVDFFRKSNLWLEQVALGAYHSLFCDK 198
            ..|      ....||..||.|.|:.||.|::.:.:.|:.||.|.:|.::::||.|..:||:|..:
Human   130 RPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQ 194

  Fly   199 KGHLYAVGHGKGGRLGIGLENSLPAPKRVKVSSKLSGDSIQCISVSRQHSLVLTHQSLVFACGLN 263
            ||.:|..|||.|||||.|.|.:...|:.|:   .|:|.:...::.::.|::|||....|:..|||
Human   195 KGQVYTCGHGPGGRLGHGDEQTCLVPRLVE---GLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLN 256

  Fly   264 TDHQLGVRDAAEQLTQFKEVVALRDKGASDLVRVIACDQHSIAYGSRCVYVWGANQGQFG--INS 326
            ..||||:..........:::.|...||.: ::.|.|...|::.:....||..|.|.||.|  ::.
Human   257 IFHQLGIIPPPSSCNVPRQIQAKYLKGRT-IIGVAAGRFHTVLWTREAVYTMGLNGGQLGCLLDP 320

  Fly   327 N-TPSITVPTLIK-LPAK-TTIRFVEANNAATVIYNEEKIITLC--YADKTRYIKTPNYEDLKSI 386
            | ...:|.|..:. |..| ..:..|.|::.|||.......|.|.  |..|....|..|   ||.:
Human   321 NGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGDIYLLADYQCKKMASKQLN---LKKV 382

  Fly   387 SVMGGNL------KNSTKGSAAALKLLMLTETNVVYLWYENTQQFYRCNFSPIRLHQIKKILYKC 445
            .|.||::      ::..:.....:.:|.:.....|:.|........:|.::..|...|..|....
Human   383 LVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCWRSVNSSLKQCRWAYPRQVFISDIALNR 447

  Fly   446 NQVMVLSEDGCVYRGKCNQIALPSSALQEKSRGS-----LDNWQDNDQNKTEISREHVI--RIEL 503
            |:::.:::||..:||:.         .:||.:.|     |.|..::..:.:.:|..:.:  ||.|
Human   448 NEILFVTQDGEGFRGRW---------FEEKRKSSEKKEILSNLHNSSSDVSYVSDINSVYERIRL 503

  Fly   504 QRVPNIDRATYIFCDEGFSSFAVLQ-ESHTKYFRKPSLPRRE--HSFKKLLHETSDCDAVHDVVF 565
            :::....||..:..|....:||:|| :..|..:..|::....  ..|.|||.|..:.|::|||.|
Human   504 EKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPAVSSSSFFEEFGKLLREADEMDSIHDVTF 568

  Fly   566 HVDGEKFAAHKFIIYSRAPGLRDLIRCYLD-------KDIYLNFDHLTG-----------KMFEL 612
            .|....|.|||:|:...:...:.|   :|.       .|||...:...|           .|||.
Human   569 QVGNRLFPAHKYILAVHSDFFQKL---FLSDGNTSEFTDIYQKDEDSAGCHLFVVEKVHPDMFEY 630

  Fly   613 ILNHIYSSYWPTEDDIDCIQQSLGP-----ANPQQRTRTCEMFLPHLEKFQL---------VELT 663
            :|..||:      |..|.:.....|     .||::...|..   .||.|...         .|:.
Human   631 LLQFIYT------DTCDFLTHGFKPRIHLNKNPEEYQGTLN---SHLNKVNFHEDDNQKSAFEVY 686

  Fly   664 KYVQSY-VRDHQFPLPNARKLFNRLYRSDHPE--------------------------------- 694
            |..|:. |.:.|...|.:.|....: |.|.|.
Human   687 KSNQAQTVSERQKSKPKSCKKGKNI-REDDPVRMLQTVAKKFDFSNLSSRLDGVRFENEKINVIA 750

  Fly   695 ----------------LYDVRIVCKDGKVLGAHKCMLVARLEYFEMMFMHLWAERSSVTMEGVP- 742
                            |.||.:...|||....|||:|.||||||..|....|.|.||.....:|
Human   751 KNTGNKLKLSQKKCSFLCDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPI 815

  Fly   743 -AEYMEPVLDYLYSLDNEAFCKQGYLETFLYNMITICDQYFIESLQNVCESLILDKISIRKCGEM 806
             ::.::.:|||||: |.....|:.....|:.:::.:.||..|..|:.:||..:.:|::::....:
Human   816 HSDILKVILDYLYT-DEAVVIKESQNVDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAML 879

  Fly   807 LEFAAMYNCKILQKGCMDFICQNLSRVLCYRSIEQCDGETLKCLNDHYRKMFKRVFDYRQITPFS 871
            |||||||:.|.|:..|:.||..|::.:|..||::......||.|::.||||.. ..|.|.|||:.
Human   880 LEFAAMYSAKQLKLSCLQFIGLNMAALLEARSLDVLSDGVLKDLSEFYRKMIP-AMDRRVITPYQ 943

  Fly   872 EAIEDELLLSFVDGCDVDLNYRMD-----AESKLKQA-AKHKQKDLRKQDARHQYEQQAISSMMR 930
            :. .|...|...|| |:.|...::     :|:..|:| .|.|:|..::.|:...|....|.....
Human   944 DG-PDISYLEVEDG-DIFLKEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPS 1006

  Fly   931 SLSISESTQGTEVPSSPQDSARSEDKNWSRVVDKKDQKRKLAETAL-------KVNNTLKHEDP- 987
            |..:.:|.:...|.|.|:......:.:::.|...:|.:.....|..       ||...:....|
Human  1007 STGLLKSGKTNSVESLPELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPV 1071

  Fly   988 -PTQELVPIERKP-LKEQTPPP-PSHETEPTTPLS---KSYN------LDFSSL----------- 1029
             ..::|.|.|:.| ||...|.| ||:..:.|:..|   .|::      :|..::
Human  1072 YSREDLKPWEKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCG 1136

  Fly  1030 -TPQSQ---------KLSQKQRKRLSSESKSWRTNNPPLVEQSS---TPVAVP---NAW--GVTT 1076
             ||:|.         ||||||||.::..:|.   ||..:....:   ||...|   |||  .:.:
Human  1137 ATPKSHLGKTVSHGVKLSQKQRKMIALTTKE---NNSGMNSMETVLFTPSKAPKPVNAWASSLHS 1198

  Fly  1077 TPSGSFND-------SFTSPTTGSSTDPTSFANMMRGHA-------------------------- 1108
            ..|.||.|       |.||.::|......||..:....|
Human  1199 VSSKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRWSFVLVAQAGVQWLDLSSPQP 1263

  Fly  1109 ------------------------------------------------TSSTTPTDQSQ-SFSRI 1124
                                                            :|.|.|:..:. :|:.|
Human  1264 LPPGFKRFSCLRHPSSWDYRCSTHGTPGPEGNHISDLPLLDSPNPWLSSSVTAPSMVAPVTFASI 1328

  Fly  1125 LADEKRQRESYERMRNKSLVHTQIEERAIAELREFYNVDNIDDETITIAR 1174
            :.:|.:|..:..|.|.|.|...||||.||.:|..||......:|.:.:.|
Human  1329 VEEELQQEAALIRSREKPLALIQIEEHAIQDLLVFYEAFGNPEEFVIVER 1378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8060	NP_611117.2	ANK	<46..138	CDD:238125	33/91 (36%)
		ANK repeat	56..87	CDD:293786	9/30 (30%)
		Ank_4	57..111	CDD:290365	21/53 (40%)
		ANK repeat	89..121	CDD:293786	16/31 (52%)
		Ank_2	95..>138	CDD:289560	15/42 (36%)
		RCC1	147..195	CDD:278826	19/47 (40%)
		RCC1	199..251	CDD:278826	18/51 (35%)
		BTB	547..>635	CDD:295341	30/105 (29%)
		BTB	684..795	CDD:279045	39/161 (24%)
		BTB	697..798	CDD:197585	35/102 (34%)
		SPOP_C_like	798..>834	CDD:269810	13/35 (37%)
IBTK	XP_006715516.1	ANK	25..135	CDD:238125	41/116 (35%)
		Ank_2	25..116	CDD:289560	37/92 (40%)
		ANK repeat	51..82	CDD:293786	9/30 (30%)
		ANK repeat	84..116	CDD:293786	16/31 (52%)
		RCC1	143..192	CDD:278826	19/48 (40%)
		RCC1	195..244	CDD:278826	18/51 (35%)
		ATS1	227..>458	CDD:227511	56/234 (24%)
		RCC1	247..299	CDD:278826	14/52 (27%)
		BTB	554..>642	CDD:279045	26/96 (27%)
		BTB	565..>639	CDD:197585	21/82 (26%)
		BTB	761..867	CDD:279045	36/106 (34%)
		BTB	769..867	CDD:197585	35/98 (36%)
		SPOP_C_like	871..931	CDD:269810	22/59 (37%)
		GVQW	1248..>1284	CDD:290611	0/35 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141908
Domainoid	1	1.000	89	1.000	Domainoid score	I7873
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34661
Inparanoid	1	1.050	403	1.000	Inparanoid score	I1920
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47467
OrthoDB	1	1.010	-	-		D168140at33208
OrthoFinder	1	1.000	-	-		FOG0006506
OrthoInspector	1	1.000	-	-		oto90868
orthoMCL	1	0.900	-	-		OOG6_105763
Panther	1	1.100	-	-	LDO	PTHR22872
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4885
SonicParanoid	1	1.000	-	-		X5481
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.800