DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8060 and btb1

DIOPT Version :9

Sequence 1:	NP_611117.2	Gene:	CG8060 / 36824	FlyBaseID:	FBgn0034113	Length:	1189	Species:	Drosophila melanogaster
Sequence 2:	NP_587711.1	Gene:	btb1 / 2538714	PomBaseID:	SPCC330.11	Length:	1347	Species:	Schizosaccharomyces pombe

Alignment Length:	1363	Identity:	315/1363 - (23%)
Similarity:	532/1363 - (39%)	Gaps:	342/1363 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 NILDDLGRSAVHMSASTARYEILEWLLNH-GAYINGQDYESGSSPLHRALYYGSIDCAVLLLRYG 114
            |..|..||:.:|::.|..:...:..||.| |..:..||.|||.:.||||:|.|:::.|.|||...
pombe    46 NQKDRYGRTVLHIAVSENKNSFVRSLLQHKGIDVFVQDEESGYTALHRAIYVGNLEAASLLLSKD 110

  Fly   115 ---ASLELLDEDTRCPLQAICRKCDDD-----DLATDSQNDVLVWGSNKNYNLGIGNEQNTNTPQ 171
               .||.:.|::...|.|.:.|.....     ||.... |::..:|:|.|..|||.|.:..::|:
pombe   111 PSFRSLRIKDKEGLSPFQFLSRVLSSTIHPVLDLPIIG-NELYGFGTNVNNTLGIANGKEPSSPE 174

  Fly   172 AV-------------DFFRKSNLWLEQVALGAYHS--LFCDKKGHLYAVGHGKGGRLGIGLE--- 218
            .|             ..|.:..:.  .|....:||  |..:...::|..|.|.|||:|...:
pombe   175 RVFLLKNQTESPTSGQLFSRDKIL--DVQASKFHSVVLTDEPSQNVYVCGIGAGGRIGFNTDVQY 237

  Fly   219 NSLPAPKRV-KVSSKLSGDSIQCISVSRQHSLVLTHQSLVFACGLNTDHQLGV------RDAAEQ 276
            |.:|.|..: ||        || ||||..|||.||....:::.|.|...:||:      :|...|
pombe   238 NFIPIPGIIHKV--------IQ-ISVSHTHSLALTKFGSIYSWGKNGSGELGLSNDELKKDDPIQ 293

  Fly   277 LTQFKEVVALRDKGASDLVRVIACDQHSIAYGSRCVYVWGANQGQFGINSNTPSITVPTLIKLPA 341
            :|. :.:.|.:|   ..::.:.|...:|:|:....:|.||.|.||.||:.:...::.|..:....
pombe   294 ITP-RRISAFKD---YQIIGMAAGKSYSVAWTDTDIYSWGLNNGQLGISDHISVVSTPRRVAGLL 354

  Fly   342 KTTIRFVEANNAATVIYNEEKIITLCYADKTRYIKTPNYEDLK-SISV-MGGNLK---------- 394
            ...|..|....|...:.....||..|           ||..:| ..:| .|.:||
pombe   355 SPVIHAVCTTRATICLLQNNSIIAFC-----------NYNQVKLPFNVDFGSSLKVTKHPLSLTR 408

  Fly   395 -NSTKGSAAALKLLMLTETNVVYLW-------------YENTQQFYRCNFSPIRLHQIK-----K 440
             |..|..|:..||.:|||...||.:             ..:|:..::  |:|:.:.:..     .
pombe   409 FNVRKLLASENKLAVLTELGEVYEFDMKLLLDRDSTSSKNSTRTSFK--FTPLWIFESSDLAALD 471

  Fly   441 ILYKCNQVMVLSEDGCVYRGKCNQIALPSSALQEKSRGS-----------LDNWQ---------- 484
            |.:..:..::|    |...|.|.:..|.|.. :|||..|           ::|.|
pombe   472 IAWTADNSLIL----CTRNGTCWKRELRSKK-REKSSSSPYSRGPYKYNRIENLQMVVGVRASAS 531

  Fly   485 ------DNDQNKTEISREHVIRIELQRVPNIDRATYIFCDEGFSSFAVLQESHTKYFRKPSL--P 541
                  .||.....|.:...:.|:|.|                   ::|...|..:.|:|.|  |
pombe   532 GSFFAIRNDYLPPPIYKPSNMLIDLLR-------------------SLLPYDHLLHVRQPRLIPP 577

  Fly   542 RREHSF-------------KKLLHETS---------DCDAVHDVVFHVDGEKFAAHKFIIYSRAP 584
            ..|...             .:||.|.|         ...:..||..:.....|.:||||:.:|:.
pombe   578 EDEDGVPIFDEDRAASSNEMQLLFEGSIPILTSYENYKQSFSDVTIYCGTSMFHSHKFILCARSS 642

  Fly   585 GLRDLI----RCYLDKDIY---LNFDHLTGKMFE-------LILNHIYS----SYWPTEDDIDCI 631
            .||.|:    :..:...||   :...|.|.::.:       ::|:::|:    |.|..:.....:
pombe   643 FLRKLLLQKKKSSVSNIIYIEEITQSHSTIRVEDIPPLAVAILLHYLYTDTLLSPWHLDSRFSPL 707

  Fly   632 QQSLGP-ANPQQRTRTCEMFLPHLEKFQLVELTKYVQSYVRDHQFPLPN-ARKLFNRLYRSDHPE 694
            :::|.. ||..:        |||     |.|:..:  |..|.....|.| ..:|:|..|.... |
pombe   708 KENLSKLANLLE--------LPH-----LAEVLPF--SVSRQPLLSLTNDILQLYNNFYVLCE-E 756

  Fly   695 LYDVRIVCKDGKVLGAHKCMLVARLEYFEMMFMHLWAERSS------VTMEGVPAEYMEPVLDYL 753
            ..|..|..|||: |.||...|..|.|||...|..:..|.:|      |.:..:..|:|..||.::
pombe   757 TMDTVIKLKDGE-LKAHGLFLSLRSEYFSSYFQFVSMESNSFDIPITVNLSHLTVEHMSIVLRHV 820

  Fly   754 YS-LDNEAF--CKQ----GYLETFLYNMITICDQYFIESLQNVCESLILDKISIRKCGEMLEFAA 811
            || |..|.|  .|:    .:||| ::.:::|.|:.....|:::.:..:|..::::....:::.:.
pombe   821 YSDLKVELFDDLKESDFHNWLET-MFEILSIADELLFLELKSIAQQSLLRFLNLKTLPTLMDLSL 884

  Fly   812 MYNCKILQKGCMDFICQNLSRVLCYRSIEQCDGETLKCLNDHYRKMFKR----VFDYRQITPFSE 872
            .|:.:.|...|:|:.|.|:...|....|.:.||       .|.:|:.:|    :.|.|...| |.
pombe   885 SYHAEELYSRCIDYACHNIEFFLEANRISEWDG-------FHLKKVAQRLTELLSDQRVHLP-SS 941

  Fly   873 AIEDELLLSFVDGCDVDLNYRMDAESKLKQAAKHKQKDLRK----QDARHQYEQQAISSMMRSLS 933
            .|.:.||:               .:..|.:...::.|.||:    |::...::.....|:.....
pombe   942 KIANRLLI---------------RDPVLMEKRNYELKVLREYLFSQESSQLWDDSPYRSIFEDRR 991

  Fly   934 ISESTQGTE---VPSSPQ-DSARSEDKNWSRVVDKKDQK---------RKLAETALKVNNTLKHE 985
            .|.|....|   ||||.| ||...||      .::|..|         .|.|..::::.|.::..
pombe   992 CSTSAVILESGIVPSSNQSDSLNKED------AEEKSPKPNVVNVTSITKTAGASVEIQNNIESA 1050

  Fly   986 D---PPTQELVPIERKPLK-----EQTPP-----PPSHETEPT----TPLSKSYNLDFSSLTPQS 1033
            .   ..||...|...:|:.     ::|.|     ..||....|    ..|.:....|.|:.|..|
pombe  1051 SSGGDKTQLNGPGADQPVTATITFDKTSPWRNRENLSHNNNTTRASLRELLEQEKADASTTTVLS 1115

  Fly  1034 Q--------KLSQKQRKR-LSSESKSWRTNNPPL-VEQSSTPVAVPNAWGVTTTPSGSFNDSFTS 1088
            .        |.||:::|: ||.:....:||...: :|...:..:  |.|.|.|...|||:.|
pombe  1116 DSRFMKAPTKKSQREKKKELSKQVPISKTNVGHIDIELGKSNHS--NPWSVATHQRGSFSSS--- 1175

  Fly  1089 PTTG------------------------------SSTDPTSFANMMRGHATSSTTP-TDQSQSFS 1122
              ||                              |:..|||:..:.:....|::.| ..|..|.|
pombe  1176 --TGVKKSFNGILREAAREEGSSQVIYQESKKRISNGSPTSWNLLTKPSPRSASLPKNSQPLSIS 1238

  Fly  1123 RILADEKRQRESYERMRN--KSLVHTQIEERAIAELREFYNVDNID-DETITIARVSRPSDIN 1182
            .|:.::|.:.||.:|..:  |::...|.||    |.::::..:::. .:.:.|.:..|.:..|
pombe  1239 EIMTEQKEEIESQKRRSSFRKTIEEIQQEE----EFQKWWEEESLRVQKELGILKTERDTSTN 1297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8060	NP_611117.2	ANK	<46..138	CDD:238125	31/90 (34%)
		ANK repeat	56..87	CDD:293786	8/31 (26%)
		Ank_4	57..111	CDD:290365	21/54 (39%)
		ANK repeat	89..121	CDD:293786	15/34 (44%)
		Ank_2	95..>138	CDD:289560	16/45 (36%)
		RCC1	147..195	CDD:278826	13/62 (21%)
		RCC1	199..251	CDD:278826	21/55 (38%)
		BTB	547..>635	CDD:295341	23/127 (18%)
		BTB	684..795	CDD:279045	36/123 (29%)
		BTB	697..798	CDD:197585	34/113 (30%)
		SPOP_C_like	798..>834	CDD:269810	6/35 (17%)
btb1	NP_587711.1	ANK	<45..127	CDD:238125	28/80 (35%)
		ANK repeat	51..83	CDD:293786	8/31 (26%)
		Ank_4	52..107	CDD:290365	21/54 (39%)
		ATS1	182..764	CDD:227511	142/649 (22%)
		RCC1_2	249..277	CDD:290274	14/36 (39%)
		RCC1	266..320	CDD:278826	11/57 (19%)
		RCC1	324..370	CDD:278826	12/45 (27%)
		BTB	615..726	CDD:279045	26/123 (21%)
		BTB	753..868	CDD:295341	34/117 (29%)
		BTB	759..871	CDD:197585	34/113 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I1108
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006506
OrthoInspector	1	1.000	-	-		oto101718
orthoMCL	1	0.900	-	-		OOG6_105763
Panther	1	1.100	-	-	LDO	PTHR22872
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4885
SonicParanoid	1	1.000	-	-		X5481
TreeFam	0	0.000	Not matched by this tool.
	9	8.980