DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8060 and Herc1

DIOPT Version :9

Sequence 1:	NP_611117.2	Gene:	CG8060 / 36824	FlyBaseID:	FBgn0034113	Length:	1189	Species:	Drosophila melanogaster
Sequence 2:	XP_006511166.1	Gene:	Herc1 / 235439	MGIID:	2384589	Length:	4885	Species:	Mus musculus

Alignment Length:	1490	Identity:	280/1490 - (18%)
Similarity:	469/1490 - (31%)	Gaps:	531/1490 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 DDLGRS-------AVHMSASTARYEILEWL---LNHGAYINGQDYESGSSPLHRALYYGSIDCAV 108
            |.|||.       .:.....:.|| :|||:   |...|.:...:.....|.....:   |.||.:
Mouse   240 DTLGRRLASELLLGLAAQRGSLRY-LLEWIEMALGASAVVYTMEKNKLLSSQEGMI---SFDCFM 300

  Fly   109 LLL--------------------RYGASLELLDEDTRCPLQAICRKCDD--------DDLAT--- 142
            .:|                    |....|..|.|...|..:.:||...|        |.:.|
Mouse   301 AILMQMRRSLGSSADRSQWREPTRTSEGLCSLYEAALCLFEEVCRMASDYSRTCASPDSIQTGDA 365

  Fly   143 ---DSQNDVLVWGSNKNYNLGIGNEQNTNTPQAVDFFRKSNLWLEQVALGAYHSLFCDKKGHLYA 204
               ....:|.|||||.::.|..|.::....|:....|..:    :.:..|.|.:......|.:.|
Mouse   366 PIVSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDA----QTIEAGQYCTFVISTDGSVRA 426

  Fly   205 VGHGKGGRLGIGLENSLPAPKRV---------KVSSKLSGDSIQCISVSRQHSLVLTHQSLVFAC 260
            .|.|..||||:|..|:....|::         ||||....|.         |:|..|.:..||:.
Mouse   427 CGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDG---------HTLAFTTEGEVFSW 482

  Fly   261 GLNTDHQLGVRDAAEQLTQFKEVVALRDKGASDLVRVIAC----DQHSIAY---GSRCVYVWGAN 318
            |.....:||..:::.|  ::.:::....:|     :|:.|    .:||.|.   |.  :|.||
Mouse   483 GDGDYGKLGHGNSSTQ--KYPKLIQGPLQG-----KVVVCVSAGYRHSAAVTEDGE--LYTWG-- 536

  Fly   319 QGQFGI--NSNTPSITVPTLIKLPAKTTIRFVEANNAATVIYNEEKIITLC-------------- 367
            :|.||.  :.::.|..:|||:|          :.:|...|.......|.|.
Mouse   537 EGDFGRLGHGDSNSRNIPTLVK----------DISNVGEVSCGSSHTIALSKDGRTVWSFGGGDN 591

  Fly   368 ----YADKTRYIKTPNYEDLKSISVMGGNLKNSTKGSAAALKLLMLTETNVVYLWYENTQQFYRC 428
                :.|..|..|....|.|:.:.:        .|..|.:...|.||.|..||.|  .......|
Mouse   592 GKLGHGDTNRVYKPKVIEALQGMFI--------RKVCAGSQSSLALTSTGQVYAW--GCGACLGC 646

  Fly   429 NFS-----------PIRLHQIKKILYKCNQVMVLSEDGCVY------RGKCNQ------IALPSS 470
            ..|           .:...:|..|....:..:.||.|..||      .|:|.|      |..|..
Mouse   647 GSSEATALRPKLIEELAATRIVDISIGDSHCLSLSHDNEVYAWGNNSMGQCGQGNSTGPITKPKK 711

  Fly   471 -------ALQEKSRGSLDN--WQDNDQNKTEISREHVIRIELQRVPNIDRATYIFCDEGFSSFAV 526
                   |:|:.|.|:..:  |....:::..::......::|:.                |:|:.
Mouse   712 VSGLDGIAIQQISAGTSHSLAWTALPRDRQVVAWHRPYCVDLEE----------------STFSH 760

  Fly   527 LQESHTKYFRK-----PSLP----RREHSFKKL-------------------------------- 550
            |:....:|..|     |.||    |..|:|.||
Mouse   761 LRSFLERYCDKINSEIPPLPFPSSREHHNFLKLCLKLLSNHLALALAGGVATSILGRQAGPLRNL 825

  Fly   551 ---LHETSDCDAVHDVVFHVDGEKFAAHKFIIYSRAPGLR---DLIRCYLDK--DIYLNFDHLTG 607
               |.:::..|.:.:||.    |..:....::   .|.||   :|:...|.:  |.:.:......
Mouse   826 LFRLMDSTVPDEIQEVVI----ETLSVGATML---LPPLRERMELLHSLLPQGPDRWESLSKGQR 883

  Fly   608 KMFELIL------NHIYS--SYWPTEDDIDCIQQSLGPANPQQR----------TRTCEMFL--- 651
            ...::||      .|:.|  .|....|..|.....:|..|...:          |...|:.:
Mouse   884 MQLDIILTSLQDHTHVASLLGYSSPSDAADLSTVCMGYGNLSDQPYGSQICHPDTHLAEILMKTL 948

  Fly   652 ----------------------------------PHLEKFQLVELTKYVQSY------------- 669
                                              .||.:. |..|.|.:.::
Mouse   949 LRNLGFYTDQAFGELEKNSDKYLLGTSSSENSQPAHLHEL-LCSLQKQLLAFCHINNVTENSSSV 1012

  Fly   670 --VRDH-QFPLPNARKLFNRLYR--SDHP-------ELYDVRIVCKDGKVLGAHKCMLV------ 716
              :..| |..||:|..:::|...  .:.|       :|.||..|...|.:|    |.:|
Mouse  1013 ALLHKHLQLLLPHATDIYSRSANLLKESPWNGSVGEKLRDVIYVSAAGSML----CQIVNSLLLL 1073

  Fly   717 -----------------------------ARLEYFEMMF-MHLWAERSSVTMEGVPAEYMEPVLD 751
                                         |.||..|:.: :|...|  .:...|||..  :|...
Mouse  1074 PVSVARPLLSYLLDLLPPLDCLNRLLPAAALLEDQELQWPLHGGPE--VIDPAGVPLP--QPAQS 1134

  Fly   752 YLYSLDNE-------AFCKQGYL---------ETFLYNMITICDQYFIESLQNVCESLILDKISI 800
            :::.:|.|       ..|..|.|         :...|.|.|   ..|.:.::       :|...:
Mouse  1135 WVWLVDLERTIALLIGRCLGGMLQGSPVSPEEQDTAYWMKT---PLFSDGVE-------MDTPQL 1189

  Fly   801 RKCGE-MLEFAAMYNCKILQKGCMDFICQNLSRVLCYRSIEQCDGETLKCLNDHYRKMFKRVFDY 864
            .||.. :||.|...|.:  ||   .|..:....|..|..:      .|.|..:..|.::..:.||
Mouse  1190 DKCMSCLLEVALSGNEE--QK---PFDYKLRPEVAVYVDL------ALGCSKEPARSLWISMQDY 1243

  Fly   865 RQITPFSEA-IEDELLLSFVDGCDVDLNYRMDAESKLKQAAKHKQKDLRKQ---DARHQYEQQAI 925
            .....:..| :.:|.||              |..|:...||..|..:|..|   ::|:| ..:::
Mouse  1244 AVSKDWDSATLSNESLL--------------DTVSRFVLAALLKHTNLLSQACGESRYQ-PGKSL 1293

  Fly   926 SSMMR---------------SLSISESTQGTEVPSSPQDSA--RSEDKNWSRVVDKKDQKRKLAE 973
            |.:.|               .|..:.|:......:..||||  ..::.:::|.:|::.:..:|||
Mouse  1294 SEVYRCVYKVRSRLLACKNLELIQTRSSSRDRWITDNQDSADVDPQEHSFTRTIDEEAEMEELAE 1358

  Fly   974 TALKVNNTLKHEDPPTQELVPIERKPLKEQTPPPPSHETEPTTPLSKSYNL--------DFSSLT 1030
                                    :..::..|.|...|.|....:..:.||        .|....
Mouse  1359 ------------------------RDREDGHPEPEDEEEEREHEVMTAGNLVFVLHVTEIFQCFL 1399

  Fly  1031 PQSQKLSQKQRKRLSSESKSW-RTNNPPLVEQSSTPVAVPNAWGVTTTPSGSFNDSFT------- 1087
            ...:....:.|.|::|.:.|. |.::||...|....|:       |..|.|  .|.:|
Mouse  1400 SAREVARSRDRDRMNSGAGSGVRADDPPPQSQQERRVS-------TDLPEG--QDVYTAACNSVI 1455

  Fly  1088 ----------SPT---------TGSSTDPTSFANMMRGHATSSTTPTDQSQ------SFSRI--- 1124
                      ||.         .|....|:..|:...|..|.|.:.|.:|:      |:..|
Mouse  1456 HRCALLILGVSPVIDELQKRREEGQLQQPSVSASEGTGLMTRSESLTAESRLVHASPSYRLIKSR 1520

  Fly  1125 ----LADEKRQRESY-------------ERMRNKSLVHTQIEERA-----IAELRE-FYN 1161
                |:..:...|.|             ...|.:..:|:|:|..:     :...|: |||
Mouse  1521 SESDLSQPESDEEGYALSGRRNVDFDLASSHRKRGPMHSQLESLSDSWTRLKHTRDWFYN 1580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8060	NP_611117.2	ANK	<46..138	CDD:238125	24/121 (20%)
		ANK repeat	56..87	CDD:293786	10/40 (25%)
		Ank_4	57..111	CDD:290365	13/63 (21%)
		ANK repeat	89..121	CDD:293786	7/51 (14%)
		Ank_2	95..>138	CDD:289560	12/70 (17%)
		RCC1	147..195	CDD:278826	12/47 (26%)
		RCC1	199..251	CDD:278826	18/60 (30%)
		BTB	547..>635	CDD:295341	21/135 (16%)
		BTB	684..795	CDD:279045	29/171 (17%)
		BTB	697..798	CDD:197585	27/152 (18%)
		SPOP_C_like	798..>834	CDD:269810	9/36 (25%)
Herc1	XP_006511166.1	ATS1	374..731	CDD:227511	91/400 (23%)
		SPRY_HERC1	2039..2196	CDD:293939
		UBA_HERC1	2760..2803	CDD:270584
		WD40	3448..3799	CDD:392136
		WD40 repeat	3456..3499	CDD:293791
		WD40 repeat	3513..3548	CDD:293791
		WD40 repeat	3610..3648	CDD:293791
		WD40 repeat	3653..3689	CDD:293791
		WD40 repeat	3697..3736	CDD:293791
		WD40 repeat	3774..3810	CDD:293791
		ATS1	4022..4370	CDD:227511
		HECTc	4497..4865	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900