DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8060 and Eea1

DIOPT Version :9

Sequence 1:	NP_611117.2	Gene:	CG8060 / 36824	FlyBaseID:	FBgn0034113	Length:	1189	Species:	Drosophila melanogaster
Sequence 2:	XP_006513585.1	Gene:	Eea1 / 216238	MGIID:	2442192	Length:	1458	Species:	Mus musculus

Alignment Length:	1049	Identity:	185/1049 - (17%)
Similarity:	353/1049 - (33%)	Gaps:	296/1049 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 SVSRQHSLVLTHQSLVFACGLNTDHQLGVRDAAEQLTQFKEVVALRDKGASDLVRVIACDQHSIA 306
            |...||.|..:.|.......|.......:|:|...|.|....:..:|:...:|..::...:.|:
Mouse   523 STELQHQLEKSKQQHQEQQALQQSATAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKGKESV- 586

  Fly   307 YGSRCVYVWGANQGQFGINSNTPSITVPTLIKLPAKTTIRFVEANNAATVIYNEEKIITLCYADK 371
                                        :|::...:.....::|....|.:.|:
Mouse   587 ----------------------------SLLEKEREDLYAKIQAGEGETAVLNQ----------- 612

  Fly   372 TRYIKTPNYEDLKSISVMGGNLKNSTKGSAAALKLLMLTETNVVYLWYENTQQFYRCNFSPIRLH 436
               ::..|:...:.::.:...|||.::....|       |.|:    ::..|:    ..:.:|..
Mouse   613 ---LQEKNHALQQQLTQLTEKLKNQSESHKQA-------EENL----HDQVQE----QKAHLRAA 659

  Fly   437 QIKKILYKCNQVMVLSEDGCVYRGKCNQ----------IALPSSALQEKSRGSLDNWQDNDQNKT 491
            | .::|.....|..||......:.|.:|          :.|.:.|.:...|..|.|..|..|:..
Mouse   660 Q-DRVLSLETSVSELSSQLNESKEKVSQLDIQIKAKTELLLSAEAAKAAQRADLQNHLDTAQHAL 723

  Fly   492 EISREHVIRIELQRVPNIDRATYIFCDEGFSSFAVLQESHTKYFRKPSLPRREHSFKKLLHETSD 556
            :..::.:.::.:|    :|:.|..|.::  ....:..|||.|          :|..|.|..|
Mouse   724 QDKQQELNKVSVQ----LDQLTAKFQEK--QEHCIQLESHLK----------DHKEKHLSLE--- 769

  Fly   557 CDAVHDVVFHVDGEKFAAHKF-IIYSRAPGLRDL-IRCYLDKDIYLNFDHLTGKMFEL------- 612
             ..|.|:..|:  :|..|... :..|:...|:.| .:..|..|:.|....|:.::.|.
Mouse   770 -QKVEDLEGHI--KKLEADALEVKASKEQALQSLQQQRQLSTDLELRNAELSRELQEQEEVVSCT 831

  Fly   613 ---------ILNHIYSSYWPTEDDIDCIQQSLGPANPQQRTRTCEMFLPHLEKFQ---------- 658
                     ||.:|..:....|::...::|.....:...:|:..|:.    ::.|
Mouse   832 KLDLQNKSEILENIKQTLTKKEEENVVLKQEFEKLSQDSKTQHKELG----DRMQAAVTELTAVK 892

  Fly   659 ------LVEL--TKYVQSYVRDHQFPLPNARKLFNRLYRSDHPELYDVRIVCKDGKVLGAHKCML 715
                  |.||  ||...|.|.|   .|.|::..|.:..:.....:.|:...||:.|    |:..:
Mouse   893 AQKDALLAELSTTKEKLSKVSD---SLKNSKSEFEKENQKGKAAVLDLEKACKELK----HQLQV 950

  Fly   716 VARLEYFEMMFMHLWAERSSVTMEGVPAEYMEPVLDYLYSLDNEAFCKQGYL------ETFLYNM 774
            .|.....|...:....|:...|.:.:..|        |.|:..|....|..|      |..|...
Mouse   951 QAESALKEQEDLKKSLEKEKETSQQLKIE--------LNSVKGEVSQAQNTLKQKEKDEQQLQGT 1007

  Fly   775 ITICDQYF------IESLQN-----VCESLILD-KISIRKCGEMLEFAAMYNCKILQKGCMDFIC 827
            |....|..      ||:||.     |.:..:|: |:..:......|.||       :||.:..:.
Mouse  1008 INQLKQSAEQKKKQIEALQGEVKNAVSQKTVLENKLQQQSSQAAQELAA-------EKGKLSALQ 1065

  Fly   828 QNLSRVLCYRSIEQCDGETLKCLNDHYRKMFKRVFDYRQITPFSEAIEDELLLSFVDGCDVDLNY 892
            .|         .|:|..:..:..:|.|.|..:.:...:.:    :::|::|.|:..|    .::.
Mouse  1066 SN---------YEKCQADLKQLQSDLYGKESELLATRQDL----KSVEEKLTLAQED----LISN 1113

  Fly   893 RMDAESKLK-----QAAKHK-QKDLRKQDARHQYEQQAISSMMRSLSISES-------------- 937
            |....::.|     ||||.. ::|..|::|..:.:.:|:....|..|:.|.
Mouse  1114 RNQIGNQNKSIQELQAAKASLEQDSAKKEALLKEQSKALEDAQREKSVKEKELVAEKSKLAEMEE 1178

  Fly   938 ---TQGTEVPSSPQDSARSEDKNWSRVVDKKDQKRKLAETALKVN---NTLK---HEDPPTQELV 993
               .|..|:....::....:.::...:.:.||.|:.|.:..|::.   ::||   .::..:|:|:
Mouse  1179 IKCRQEKEITKLNEELKSHKQESIKEITNLKDAKQLLIQQKLELQGRVDSLKAALEQEKESQQLM 1243

  Fly   994 PIERKPLKEQTPPPPSHETEPTTPL----------SKSYNLDFSSLTPQSQKLSQKQRKRLSSES 1048
               |:.:|::........:|....|          .|.:..:.:.||.|...|::    .|.:..
Mouse  1244 ---REQVKKEEEKRKEEFSEKEAKLHSEIKEKEAGMKKHEENEAKLTMQVTTLNE----NLGTVK 1301

  Fly  1049 KSWRTNNPPLVEQSSTPVAVPNAWGVTTTPSGSFNDSFTSPTTGSSTDPTSFANMMRGHATSSTT 1113
            |.|:::...:.|..                              ..||.      :||.......
Mouse  1302 KEWQSSQRRVSELE------------------------------KQTDD------LRGEIAVLEA 1330

  Fly  1114 PTDQSQSFSRILAD---------EKRQRESYERMR---------------NKSL--VHTQIEERA 1152
            ....:|...|.|.:         ||.|.::.|..|               |:||  .|||...|.
Mouse  1331 TVQNNQDERRALLERCLKGEGEIEKLQTKALELQRKLDNTTAAVQELGRENQSLQIKHTQALNRK 1395

  Fly  1153 IAELREFYN 1161
            .||..|..|
Mouse  1396 WAEDNEVQN 1404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8060	NP_611117.2	ANK	<46..138	CDD:238125
		ANK repeat	56..87	CDD:293786
		Ank_4	57..111	CDD:290365
		ANK repeat	89..121	CDD:293786
		Ank_2	95..>138	CDD:289560
		RCC1	147..195	CDD:278826
		RCC1	199..251	CDD:278826	4/8 (50%)
		BTB	547..>635	CDD:295341	21/105 (20%)
		BTB	684..795	CDD:279045	25/127 (20%)
		BTB	697..798	CDD:197585	25/118 (21%)
		SPOP_C_like	798..>834	CDD:269810	6/35 (17%)
Eea1	XP_006513585.1	SMC_prok_B	<130..794	CDD:274008	58/351 (17%)
		Smc	504..1346	CDD:224117	169/989 (17%)
		FYVE_EEA1	1394..1456	CDD:277269	5/11 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900