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Protein Alignment CG8060 and Herc2

DIOPT Version :10

Sequence 1:	NP_611117.2	Gene:	CG8060 / 36824	FlyBaseID:	FBgn0034113	Length:	1189	Species:	Drosophila melanogaster
Sequence 2:	NP_034548.2	Gene:	Herc2 / 15204	MGIID:	103234	Length:	4836	Species:	Mus musculus

Alignment Length:	969	Identity:	176/969 - (18%)
Similarity:	299/969 - (30%)	Gaps:	348/969 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 LATDSQNDVLVWGSNKNYNLGIGNEQNTNTPQAVDFFRKSNLWLEQVALGAYHSLFCDKKGHLYA 204
            ||..|:.:|..||..::..||.||....:.|:.::..|  .:.:..||.|..||......|.||.
Mouse  4054 LALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLR--GIEVVDVAAGGAHSACVTAAGDLYT 4116

  Fly   205 VGHGKGGRLGIGLENSLPAPKRV------------------------------------------ 227
            .|.|:.||||.........||.|
Mouse  4117 WGKGRYGRLGHSDSEDQLKPKLVEALQGHRVIDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGR 4181

  Fly   228 ------KVSSK---LSGDSIQCISVSRQHSLVLTHQSLVFACGLNTDHQLGVRDAAEQLTQFKEV 283
                  ||..|   |:|..:..:....|.|:.||....|:..|....|:|| ..:.:.:.:.::|
Mouse  4182 GGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLG-HGSDDHVRRPRQV 4245

  Fly   284 VALRDKGASDLVRVIACDQHSIAYGS-RC--------VYVWGAN-QGQFGINSNTPSITVPTLIK 338
            ..|:.|      :|||     ||.|| .|        ||.||.| :||.| :..|.:|..|.|:.
Mouse  4246 QGLQGK------KVIA-----IATGSLHCVCCTEDGEVYTWGDNDEGQLG-DGTTNAIQRPRLVA 4298

  Fly   339 LPAKTTIRFVEANNAATVIYNEEKIITLCYADKTRYIKTPNYEDLKSISVMGGNLKNSTKGSAAA 403
            ......:..|...:|.|:.::..|..:   |.|........|..|:.|.::.  |:|
Mouse  4299 ALQGKKVNRVACGSAHTLAWSTSKPAS---AGKLPAQVPMEYNHLQEIPIIA--LRN-------- 4350

  Fly   404 LKLLMLTETNVVYLWYENTQQFYRCNFSPIRLHQIKKILYKCNQVMVLSEDGCVYRGKCNQIALP 468
             :||:                          ||.|.::...|..:..|       .|..::..|.
Mouse  4351 -RLLL--------------------------LHHISELFCPCIPMFDL-------EGSLDETGLG 4381

  Fly   469 SSALQEKSRGSLDNWQDNDQNKTEI-------SREHVIRIELQRV-------------PNIDRAT 513
            .|...:..||.|.: |..:....::       .|:|...:||.|:             |:..::.
Mouse  4382 PSVGFDTLRGILIS-QGKEAAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSKGGLAGPDGTKSV 4445

  Fly   514 YIFCDEGFSSFAVLQESHTKYFRKPS---LPRREHSFKKLLHETSDC-----DAVHDV------- 563
            :.......|||:            |.   ||.|....|.:.....||     :::.::
Mouse  4446 FGQMCAKMSSFS------------PDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNG 4498

  Fly   564 -----VFHVDGEKFAAHKFIIYSRAPGLRDLIRCYLDK--DIYLNFDHLTGKMFELILNHIYSSY 621
                 :...:|...:......|...|..|..:.|.:.:  .:.|.....||....|   ::....
Mouse  4499 LTPLLIVTPNGRDESGANRDCYLLNPATRAPVHCSMFRFLGVLLGIAIRTGSPLSL---NLAEPV 4560

  Fly   622 WP-------TEDDIDCIQQSLGPANPQQRTRTCEMFLPHLEKFQLVELTKYVQSYVRDHQFPLPN 679
            |.       |..|:..:.:.               |:|.|             .|:||::
Mouse  4561 WKQLAGMSLTIADLSEVDKD---------------FIPGL-------------MYIRDNE----- 4592

  Fly   680 ARKLFNRLYRSDHPELYDVRIVCKDGKVLGAHKCMLVARLEYFEMMFM------------HLWAE 732
                                                 |..|.||.|.:            .|.::
Mouse  4593 -------------------------------------ATSEEFEAMSLPFTVPSASGQDIQLSSK 4620

  Fly   733 RSSVTMEGVPAEYMEPVLDY-LYSLDNE-AFCKQGYLETFLYNMITICDQYFIESLQNVCESLIL 795
            .:.:|::. .|||:...::| |:..|.: |..::|........::::...|.:|::  ||
Mouse  4621 HTHITLDN-RAEYVRLAINYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETM--VC----- 4677

  Fly   796 DKISIRKCGEMLEFAAMYNCKILQKGCMDFICQNLSRVLCYRSIE------QCDGETLKCLNDHY 854
                                     |..|.....|..|..|:.||      |...|.::..::..
Mouse  4678 -------------------------GSPDIPLHLLKSVATYKGIEPSASLVQWFWEVMESFSNTE 4717

  Fly   855 RKMFKR-----------VFDYR----------QITPFSEAIEDELLLSFV-----DGCDVDLNYR 893
            |.:|.|           :.|:|          :..|....:.:.....|:     ..|      :
Mouse  4718 RSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSC------K 4776

  Fly   894 MDAESKLKQAAKHKQKDLRKQDARHQYEQQAISSMMRSLSISESTQGTEVPSSPQDSAR 952
            ...|.|||.|. |..|.:...|    |.:.|::....:...||.:...:..|...||.:
Mouse  4777 QVLEEKLKYAI-HFCKSIDTDD----YARIALTGEPAADDSSEDSDNEDADSFASDSTQ 4830

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.