DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8060 and Herc2

DIOPT Version :9

Sequence 1:NP_611117.2 Gene:CG8060 / 36824 FlyBaseID:FBgn0034113 Length:1189 Species:Drosophila melanogaster
Sequence 2:NP_001347009.1 Gene:Herc2 / 15204 MGIID:103234 Length:4836 Species:Mus musculus


Alignment Length:969 Identity:176/969 - (18%)
Similarity:299/969 - (30%) Gaps:348/969 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   140 LATDSQNDVLVWGSNKNYNLGIGNEQNTNTPQAVDFFRKSNLWLEQVALGAYHSLFCDKKGHLYA 204
            ||..|:.:|..||..::..||.||....:.|:.::..|  .:.:..||.|..||......|.||.
Mouse  4054 LALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLR--GIEVVDVAAGGAHSACVTAAGDLYT 4116

  Fly   205 VGHGKGGRLGIGLENSLPAPKRV------------------------------------------ 227
            .|.|:.||||.........||.|                                          
Mouse  4117 WGKGRYGRLGHSDSEDQLKPKLVEALQGHRVIDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGR 4181

  Fly   228 ------KVSSK---LSGDSIQCISVSRQHSLVLTHQSLVFACGLNTDHQLGVRDAAEQLTQFKEV 283
                  ||..|   |:|..:..:....|.|:.||....|:..|....|:|| ..:.:.:.:.::|
Mouse  4182 GGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLG-HGSDDHVRRPRQV 4245

  Fly   284 VALRDKGASDLVRVIACDQHSIAYGS-RC--------VYVWGAN-QGQFGINSNTPSITVPTLIK 338
            ..|:.|      :|||     ||.|| .|        ||.||.| :||.| :..|.:|..|.|:.
Mouse  4246 QGLQGK------KVIA-----IATGSLHCVCCTEDGEVYTWGDNDEGQLG-DGTTNAIQRPRLVA 4298

  Fly   339 LPAKTTIRFVEANNAATVIYNEEKIITLCYADKTRYIKTPNYEDLKSISVMGGNLKNSTKGSAAA 403
            ......:..|...:|.|:.::..|..:   |.|........|..|:.|.::.  |:|        
Mouse  4299 ALQGKKVNRVACGSAHTLAWSTSKPAS---AGKLPAQVPMEYNHLQEIPIIA--LRN-------- 4350

  Fly   404 LKLLMLTETNVVYLWYENTQQFYRCNFSPIRLHQIKKILYKCNQVMVLSEDGCVYRGKCNQIALP 468
             :||:                          ||.|.::...|..:..|       .|..::..|.
Mouse  4351 -RLLL--------------------------LHHISELFCPCIPMFDL-------EGSLDETGLG 4381

  Fly   469 SSALQEKSRGSLDNWQDNDQNKTEI-------SREHVIRIELQRV-------------PNIDRAT 513
            .|...:..||.|.: |..:....::       .|:|...:||.|:             |:..::.
Mouse  4382 PSVGFDTLRGILIS-QGKEAAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSKGGLAGPDGTKSV 4445

  Fly   514 YIFCDEGFSSFAVLQESHTKYFRKPS---LPRREHSFKKLLHETSDC-----DAVHDV------- 563
            :.......|||:            |.   ||.|....|.:.....||     :::.::       
Mouse  4446 FGQMCAKMSSFS------------PDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNG 4498

  Fly   564 -----VFHVDGEKFAAHKFIIYSRAPGLRDLIRCYLDK--DIYLNFDHLTGKMFELILNHIYSSY 621
                 :...:|...:......|...|..|..:.|.:.:  .:.|.....||....|   ::....
Mouse  4499 LTPLLIVTPNGRDESGANRDCYLLNPATRAPVHCSMFRFLGVLLGIAIRTGSPLSL---NLAEPV 4560

  Fly   622 WP-------TEDDIDCIQQSLGPANPQQRTRTCEMFLPHLEKFQLVELTKYVQSYVRDHQFPLPN 679
            |.       |..|:..:.:.               |:|.|             .|:||::     
Mouse  4561 WKQLAGMSLTIADLSEVDKD---------------FIPGL-------------MYIRDNE----- 4592

  Fly   680 ARKLFNRLYRSDHPELYDVRIVCKDGKVLGAHKCMLVARLEYFEMMFM------------HLWAE 732
                                                 |..|.||.|.:            .|.::
Mouse  4593 -------------------------------------ATSEEFEAMSLPFTVPSASGQDIQLSSK 4620

  Fly   733 RSSVTMEGVPAEYMEPVLDY-LYSLDNE-AFCKQGYLETFLYNMITICDQYFIESLQNVCESLIL 795
            .:.:|::. .|||:...::| |:..|.: |..::|........::::...|.:|::  ||     
Mouse  4621 HTHITLDN-RAEYVRLAINYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETM--VC----- 4677

  Fly   796 DKISIRKCGEMLEFAAMYNCKILQKGCMDFICQNLSRVLCYRSIE------QCDGETLKCLNDHY 854
                                     |..|.....|..|..|:.||      |...|.::..::..
Mouse  4678 -------------------------GSPDIPLHLLKSVATYKGIEPSASLVQWFWEVMESFSNTE 4717

  Fly   855 RKMFKR-----------VFDYR----------QITPFSEAIEDELLLSFV-----DGCDVDLNYR 893
            |.:|.|           :.|:|          :..|....:.:.....|:     ..|      :
Mouse  4718 RSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSC------K 4776

  Fly   894 MDAESKLKQAAKHKQKDLRKQDARHQYEQQAISSMMRSLSISESTQGTEVPSSPQDSAR 952
            ...|.|||.|. |..|.:...|    |.:.|::....:...||.:...:..|...||.:
Mouse  4777 QVLEEKLKYAI-HFCKSIDTDD----YARIALTGEPAADDSSEDSDNEDADSFASDSTQ 4830

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8060NP_611117.2 ANK <46..138 CDD:238125
ANK repeat 56..87 CDD:293786
Ank_4 57..111 CDD:290365
ANK repeat 89..121 CDD:293786
Ank_2 95..>138 CDD:289560
RCC1 147..195 CDD:278826 14/47 (30%)
RCC1 199..251 CDD:278826 19/102 (19%)
BTB 547..>635 CDD:295341 15/113 (13%)
BTB 684..795 CDD:279045 19/124 (15%)
BTB 697..798 CDD:197585 19/114 (17%)
SPOP_C_like 798..>834 CDD:269810 3/35 (9%)
Herc2NP_001347009.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 58..90
RCC1 1-1 416..462
RCC1 1-2 463..513
ATS1 <494..787 CDD:227511
RCC1 1-3 514..569
RCC1 1-4 570..621
RCC1 1-5 624..675
RCC1 1-6 676..727
RCC1 1-7 729..779
Cyt-b5 1212..1283 CDD:365921
MIB_HERC2 1871..1930 CDD:369043
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2351..2376
UBA_HERC2 2461..2508 CDD:270585
Cul7 2555..2632 CDD:371573
SH3_15 2640..2697 CDD:375773
ZZ_HERC2 2707..2751 CDD:239084
APC10-HERC2 2766..2911 CDD:176485
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2928..2947
ATS1 2957..3323 CDD:227511
RCC1 2-1 2959..3010
RCC1 2-2 3011..3065
RCC1 2-3 3066..3117
RCC1 2-4 3119..3169
RCC1 2-5 3172..3223
RCC1 2-6 3225..3275
RCC1 2-7 3276..3327
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3479..3499
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3517..3537
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3604..3632
RCC1 3-1 3953..4004
RCC1 3-2 4006..4058 2/3 (67%)
ATS1 4025..4330 CDD:227511 72/293 (25%)
RCC1 3-3 4060..4110 14/51 (27%)
RCC1 3-4 4112..4164 12/51 (24%)
RCC1 3-5 4166..4216 8/49 (16%)
RCC1 3-6 4218..4268 16/61 (26%)
RCC1 3-7 4270..4320 15/50 (30%)
HECTc 4423..4794 CDD:238033 73/495 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4806..4836 5/25 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5184
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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