DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8060 and RCBTB2

DIOPT Version :9

Sequence 1:	NP_611117.2	Gene:	CG8060 / 36824	FlyBaseID:	FBgn0034113	Length:	1189	Species:	Drosophila melanogaster
Sequence 2:	XP_016875858.1	Gene:	RCBTB2 / 1102	HGNCID:	1914	Length:	561	Species:	Homo sapiens

Alignment Length:	788	Identity:	152/788 - (19%)
Similarity:	237/788 - (30%)	Gaps:	325/788 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 ASLELLDEDTRCPLQAICRK--------------CDDDDLATDSQNDVLVWGSNKNYNLGIGNEQ 165
            :||::||.. :.|:.::|.:              ..::.|.|...:::.|.|:|....||:|:.|
Human    31 SSLKMLDVG-KWPIFSLCSEEELQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQ 94

  Fly   166 NTNTPQAVDFFRKSNLWLEQVALGAY----HSLFCDKKGHLYAVGHGKGGRLGIGLENSLPAPKR 226
            :|..|:.:|     :|..:::|..:|    |.:....:|.::..||....:||.|..|....|
Human    95 STIEPRRLD-----SLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVP-- 152

  Fly   227 VKVSSKLSGDSIQCISVSRQHSLVLTHQSLVFACGLNTDHQLGVRDAAEQLTQFKEVVALRDKGA 291
            ..:|:.||...:..::....||||||....|||.|.|...|:|......|....:....|::|
Human   153 CHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNK-- 215

  Fly   292 SDLVRVIACDQHSIAYGSRC---------VYVWGAN-QGQFGINSNTPSITVPTLIKLPAKTTIR 346
              :|..|||       |..|         |||||.| .||.|:.:   |...||..::.|...||
Human   216 --VVVTIAC-------GQMCCMAVVDTGEVYVWGYNGNGQLGLGN---SGNQPTPCRVAALQGIR 268

  Fly   347 FVEANNAATVIYNEEKIITLCYADKTRYIKTPNYEDLKSISVMGGNLKNSTKGSAAALKLLMLTE 411
            .
Human   269 V---------------------------------------------------------------- 269

  Fly   412 TNVVYLWYENTQQFYRCNFSPIRLHQIKKILYKCNQVMVLSEDGCVYRGKCNQIALPSSALQEKS 476
                        |...|.::               ..:||:::|.||....|            |
Human   270 ------------QRVACGYA---------------HTLVLTDEGQVYAWGAN------------S 295

  Fly   477 RGSLDNWQDNDQNKTEISREHVIRIELQRVPNIDRATYIFCDEGFSSFAVLQESHTKYFRKPSLP 541
            .|.|     ...||:..|....:.:|..|:
Human   296 YGQL-----GTGNKSNQSYPTPVTVEKDRI----------------------------------- 320

  Fly   542 RREHSFKKLLHETSDCDAVHDVVFHVDGEKFAAHKFIIYSRAPGLRDLIRCYLDKDIYLNFDHLT 606
                      .|.:.|.:.|.......|
Human   321 ----------IEIAACHSTHTSAAKTQG------------------------------------- 338

  Fly   607 GKMFELILNHIYSSYWPTEDDIDCIQQSLGPANPQQRTRTCEMFLPHLEKFQLVE---------- 661
                    .|:|  .|.     .|..||              :.||||..|...:
Human   339 --------GHVY--MWG-----QCRGQS--------------VILPHLTHFSCTDDVFACFATPA 374

  Fly   662 LTKYVQSYVRDHQFPLPNARKLFNRLYRSDHPELYDVRIVCKDGKVLGAHKCMLVARLEYFEMMF 726
            :|..:.|...|....:..:.|     ...|:|:..|::.:. |||.:.|||.:|..|.|:|
Human   375 VTWRLLSVEPDDHLTVAESLK-----REFDNPDTADLKFLV-DGKYIYAHKVLLKIRCEHF---- 429

  Fly   727 MHLWAERSS--------VTMEGVPAEYMEPV----LDYLY----SLDNEAFCKQGYLETFLYNMI 775
                  |||        |.|    :|:..||    |:|||    ||..|.......|.||
Human   430 ------RSSLEDNEDDIVEM----SEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATF----- 479

  Fly   776 TICDQYFIESLQNVCESLILDKISIRKCGEMLEFAAMYNCKILQKGCMDFICQNLSRVLCYRSIE 840
                 |....|:.:|:..|...|.......:|..|..|:.:.|::.|..|...:|:.|.......
Human   480 -----YRENRLKKLCQQTIKQGICEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFA 539

  Fly   841 QCDGETLK 848
            :.|.:.||
Human   540 EMDHDLLK 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8060	NP_611117.2	ANK	<46..138	CDD:238125	6/36 (17%)
		ANK repeat	56..87	CDD:293786
		Ank_4	57..111	CDD:290365
		ANK repeat	89..121	CDD:293786	2/5 (40%)
		Ank_2	95..>138	CDD:289560	6/36 (17%)
		RCC1	147..195	CDD:278826	14/51 (27%)
		RCC1	199..251	CDD:278826	14/51 (27%)
		BTB	547..>635	CDD:295341	9/87 (10%)
		BTB	684..795	CDD:279045	34/126 (27%)
		BTB	697..798	CDD:197585	33/116 (28%)
		SPOP_C_like	798..>834	CDD:269810	8/35 (23%)
RCBTB2	XP_016875858.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810