DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8060 and Ibtk

DIOPT Version :9

Sequence 1:	NP_611117.2	Gene:	CG8060 / 36824	FlyBaseID:	FBgn0034113	Length:	1189	Species:	Drosophila melanogaster
Sequence 2:	NP_001074751.1	Gene:	Ibtk / 108837	MGIID:	1918677	Length:	1352	Species:	Mus musculus

Alignment Length:	1362	Identity:	350/1362 - (25%)
Similarity:	587/1362 - (43%)	Gaps:	229/1362 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DCTAKCRLRQHGNAITAALTKRSIDNQKLASFIFKTCGNFANILDDLGRSAVHMSASTARYEILE 74
            |||:|||..:|...:.:.:||.|  ..::.||:.:.|.|.|.:.|..||:|.|:::|..:..:|:
Mouse     7 DCTSKCRSLKHALDVLSVVTKGS--ESQIKSFLARYCYNAATVKDAFGRNAGHLASSCGKKGVLD 69

  Fly    75 WLLNHGAYINGQDYESGSSPLHRALYYGSIDCAVLLLRYGASLELLDEDTRCPLQAICRKCDDDD 139
            ||:..|..:..:|.|||.:.|||:::||.|||...||::|.||.:.|::...||..:.:......
Mouse    70 WLIEKGVDLLVKDKESGWTALHRSVFYGHIDCVWSLLKHGVSLYMQDKEGLSPLDLLMKDRPTHV 134

  Fly   140 LATDSQ-NDVLVWGSNKNYNLGIGNEQNTNTPQAVDFFRKSNLWLEQVALGAYHSLFCDKKGHLY 203
            :..|:. .:|..||.|.|:.||.|::.:.:.|:.:|.|.:|.::::||.|..:||:|..:||.:|
Mouse   135 VFKDTDPTEVYTWGDNTNFTLGHGSQNSKHHPELLDLFSRSGVYVKQVVLCKFHSVFLSQKGQVY 199

  Fly   204 AVGHGKGGRLGIGLENSLPAPKRVKVSSKLSGDSIQCISVSRQHSLVLTHQSLVFACGLNTDHQL 268
            ..|||:|||||.|.|.:...|:.|:   .|||.:...::.::.|::|||....|:..|||..|||
Mouse   200 TCGHGRGGRLGHGDEQTCLVPRLVE---GLSGHNCSQVAAAKDHTVVLTDDGCVYTFGLNMFHQL 261

  Fly   269 GVRDAAEQLTQFKEVVALRDKGASDLVRVIACDQHSIAYGSRCVYVWGANQGQFG--INSN-TPS 330
            |:..........:::.|...||.: ::.|.|...|::.:....||..|.|.||.|  ::.| ...
Mouse   262 GIIPPPASCNVPRQIQAKYLKGRT-IIGVAAGRFHTVLWTREAVYTLGLNGGQLGHLLDPNGEKC 325

  Fly   331 ITVPTLIK-LPAK-TTIRFVEANNAATVIYNEEKIITLC--YADKTRYIKTPNYEDLKSISVMGG 391
            :|.|..:. |..| ..:..|.|::.|||.......|.|.  |..|....|..|   ||.:.|.||
Mouse   326 VTTPRQVSALHHKDIAVSLVAASDGATVCVTTRGDIYLLADYQCKKMATKQLN---LKKVLVSGG 387

  Fly   392 NL------KNSTKGSAAALKLLMLTETNVVYLWYENTQQFYRCNFSPIRLHQIKKILYKCNQVMV 450
            .:      ::.|:.....:.:|.:.....|:.|...:....:|.::..|...|..|....|:::.
Mouse   388 CMEYKVDPEHLTENGGQKICVLAMDGAGRVFCWRSISSSLKQCRWAYPRQVSISDIALNRNEILF 452

  Fly   451 LSEDGCVYRGKCNQIALPSSALQEKSRGSLDNWQDNDQNKTEISREHVI--RIELQRVPNIDRAT 513
            :::||..::||..:....:|   ||....|.|...:..:.:.:...:.:  ||.|:::|...||.
Mouse   453 VTQDGEGFKGKWFEDKRKNS---EKKADILPNLHHSSSDVSCVPDTNSVYERIRLEKLPFAHRAV 514

  Fly   514 YIFCDEGFSSFAVLQ-ESHTKYFRKPSLPRRE--HSFKKLLHETSDCDAVHDVVFHVDGEKFAAH 575
            .:..|....:||:|| :..|..:..|.:....  ..|.|||.||.:.|:.|||.|.|....|.||
Mouse   515 SVSTDPSGCNFAILQSDPKTSLYEIPVVSSSSFFEEFGKLLRETDEMDSFHDVTFQVGNRHFPAH 579

  Fly   576 KFIIYSRAPGLRDLIRCYLD-------KDIYLNFDHLTG-----------KMFELILNHIYSSYW 622
            |:|:..|:...:.|   :|.       .|:|...:...|           .:||.:|..:|:
Mouse   580 KYILAVRSDFFQKL---FLSDGSSLELTDVYQKDEDAAGCHLFVVEKVHPDLFEYLLQFMYT--- 638

  Fly   623 PTEDDIDCIQQSLGP------------ANPQQRTRTCEMFLPHLEK--FQLV------------- 660
               |..|.:.....|            .:|.....|....:...:|  |::.
Mouse   639 ---DTCDLLTHGFKPRMIVKRKAEDCEGSPDSHLHTVNCHVDDKQKSAFEVYRSNQAHTLSERQK 700

  Fly   661 ---------------ELTKYVQSYVRDHQFPLPN------------------ARKLFNRLYRSDH 692
                           :..:.:||..:  :|.|.|                  |:|..|:|..|..
Mouse   701 SKPKSSKKGKGVGDDDPVRMLQSVAK--KFGLSNLSSRLEGVRLENEKINVIAKKTGNKLKLSQK 763

  Fly   693 --PELYDVRIVCKDGKVLGAHKCMLVARLEYFEMMFMHLWAERSSVTMEGVP--AEYMEPVLDYL 753
              ..||||.:...|||....|||:|.||||||..|....|.|.||.....:|  :|.::.:||||
Mouse   764 KCSFLYDVTMKSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYL 828

  Fly   754 YSLDNEAFCKQGYLETFLYNMITICDQYFIESLQNVCESLILDKISIRKCGEMLEFAAMYNCKIL 818
            |: |.....|:.....|:.:::.:.||..|..|:.:||..:.:.::::....:|||||:||...|
Mouse   829 YT-DEAVVIKESQNVDFVCSVLVVADQLLITRLKEICEVALTENLTLKNAAMLLEFAALYNAGQL 892

  Fly   819 QKGCMDFICQNLSRVLCYRSIEQCDGETLKCLNDHYRKMFKRVFDYRQITPFSEA-------IED 876
            :..|:.||..|::.:|..||::....:.||.|:..||||.. ..:.|.|||:.:.       :||
Mouse   893 KLSCLQFIGLNMAALLEARSLDVLSEDVLKDLSIFYRKMIP-AMERRVITPYQDGPDISSMQVED 956

  Fly   877 ELLLSFVDGCDVDLNYRMDAESKLKQA-AKHKQKDLRKQDARHQYEQQAISSMMRSLSISESTQG 940
            ..:. |.:..:::.||   :|:..|:| .:.|:|..::.|:...|....:.....|..:.:|.:.
Mouse   957 GEVF-FKEEINMEPNY---SETMFKKAKTRAKKKPRKRSDSSGGYTLSDVIQSPPSAGLLKSAKT 1017

  Fly   941 TEVPSSPQDSARSEDKNWSRVVDKKD----------QKRKLAETALKVNNTLKHEDPP--TQELV 993
            ..|.|.|:......:.:::.|...:|          ...|:...|....|.:   .||  .:::.
Mouse  1018 NSVESLPELLTSDSEGSYAGVASPRDLQSPDFTAGFHSDKVEGKAKPYVNGI---PPPCTREDVK 1079

  Fly   994 PIERKPLKEQTPP-PPSHETE-------------PTTP--------LSKSYNLDFSSLTPQSQ-- 1034
            |.|:.|..:..|. .||:..:             |.:|        :....|.......|:|.
Mouse  1080 PWEKSPTTKSAPQFIPSNRVDTAASSSWLAGSCSPVSPPVVDLRTIMETEENRQKYGAAPKSNLG 1144

  Fly  1035 -------KLSQKQRKRLSSESKSWRTNNPPLVEQSSTPVAVP---NAWGVTTTP-SGSFNDSFTS 1088
                   ||||||||.::..:|...:....:....:.|...|   |||....:| |.||.|....
Mouse  1145 KIISHGIKLSQKQRKMIALTTKENNSGTNSMEAILTAPSKSPKPANAWAPLHSPLSRSFRDFLLE 1209

  Fly  1089 -----PTTGS----------STDPTSFANMMR--GHAT--------------SSTTPTDQSQ--- 1119
                 |..||          .|:.:...|:.|  .|.|              .|..|...|.
Mouse  1210 EKKPVPGYGSGDHVKKVCFKGTENSPALNVARCSTHGTPGLESNHVSDFPLLDSPNPWQSSSLAA 1274

  Fly  1120 -------SFSRILADEKRQRESYERMRNKSLVHTQIEERAIAELREFYNVDNIDDETITIAR 1174
                   :|:.|:.:|::|..:..|.|.|.|...|:||.||.:|..||......:|.:.:.|
Mouse  1275 SPAVAPVTFASIVEEERQQEAALIRSREKPLALIQVEEHAIQDLLVFYEAFGNPEEFVVVER 1336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8060	NP_611117.2	ANK	<46..138	CDD:238125	33/91 (36%)
		ANK repeat	56..87	CDD:293786	9/30 (30%)
		Ank_4	57..111	CDD:290365	21/53 (40%)
		ANK repeat	89..121	CDD:293786	16/31 (52%)
		Ank_2	95..>138	CDD:289560	16/42 (38%)
		RCC1	147..195	CDD:278826	17/47 (36%)
		RCC1	199..251	CDD:278826	19/51 (37%)
		BTB	547..>635	CDD:295341	29/105 (28%)
		BTB	684..795	CDD:279045	41/114 (36%)
		BTB	697..798	CDD:197585	36/102 (35%)
		SPOP_C_like	798..>834	CDD:269810	12/35 (34%)
Ibtk	NP_001074751.1	Ank_2	25..116	CDD:289560	35/92 (38%)
		ANK	<47..135	CDD:238125	30/87 (34%)
		ANK repeat	51..82	CDD:293786	9/30 (30%)
		ANK 1	51..80		9/28 (32%)
		ANK repeat	84..116	CDD:293786	16/31 (52%)
		ANK 2	85..114		15/28 (54%)
		RCC1 1	141..194		18/52 (35%)
		RCC1	143..192	CDD:278826	17/48 (35%)
		RCC1 2	195..246		21/53 (40%)
		RCC1_2	232..260	CDD:290274	8/27 (30%)
		RCC1	247..299	CDD:278826	14/52 (27%)
		RCC1 3	248..301		14/53 (26%)
		BTB	562..>643	CDD:279045	22/89 (25%)
		BTB	566..>643	CDD:197585	20/85 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	692..716		0/23 (0%)
		BTB	762..868	CDD:279045	38/106 (36%)
		BTB	770..872	CDD:197585	36/102 (35%)
		SPOP_C_like	872..>919	CDD:269810	15/46 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	976..1002		6/25 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1032..1094		11/64 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831953
Domainoid	1	1.000	77	1.000	Domainoid score	I8884
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34661
Inparanoid	1	1.050	403	1.000	Inparanoid score	I1907
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47467
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006506
OrthoInspector	1	1.000	-	-		oto94450
orthoMCL	1	0.900	-	-		OOG6_105763
Panther	1	1.100	-	-	LDO	PTHR22872
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4885
SonicParanoid	1	1.000	-	-		X5481
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790